NIH R21 funding opportunities: Exploratory/Developmental Research Grant
33 NIH notices for R21 (Exploratory/Developmental Research Grant) are open and 1 forecast. Early, exploratory ideas that may not have preliminary data yet,...
- Open notices33
- Forecast1
- Projects funded under them10,906
Open NIH R21 notices
- Secondary Analysis and Integration of Existing Data to Elucidate Cancer Risk and Related Outcomes (R21 Clinical Trials Not Allowed)
Open - Ethical, Legal and Social Implications (ELSI) Exploratory/Developmental Research Grant (R21 Clinical Trial Optional)
Open - Developing novel theory and methods for understanding the genetic architecture of complex human traits (R21 Clinical Trial Not Allowed)
Open - Mechanisms that Impact Cancer Risk with Use of Incretin Mimetics (R21 Clinical Trial Not Allowed)
Open - New Approaches for Measuring Brain Changes Across Longer Timespans (R21 Clinical Trial Optional)
Open - Early-Stage Dissemination and Implementation Research in Communication Disorders (R21 Clinical Trial Optional)
Open - Preclinical Proof of Concept Studies for Rare Diseases (R21 Clinical Trial Not Allowed)
Open - Change of Recipient Organization (Type 7 Parent Clinical Trial Optional)
Open - Cutting-Edge Basic Research Awards (CEBRA) (R21 Clinical Trial Optional)
Open - Advancement and Innovation in Measurement of Language Development and Predictors (R21 Clinical Trial Not Allowed)
Open - NIDCD Early Career Research(ECR) Award (R21 Clinical Trial Optional)
Open - NEI Research Grant for Vision-Related Secondary Data Analysis (R21 Clinical Trial Not Allowed)
Open - Mechanistic Evaluation of Therapeutic Targets derived from Treatable Traits to Improve CNS Outcomes in People with HIV (R21/R33 Clinical Trial Not Allowed)
Open - Basic Research in Cancer Health Disparities (R21 Clinical Trial Not Allowed)
Open - Innovative Screening Approaches and Therapies for Screenable Disorders in Newborns (R21 - Clinical Trial Optional)
Open - Pilot Studies of Biological, Behavioral and Social Mechanisms Contributing to HIV Pathogenesis Within the Mission of NIDDK (R21 Clinical Trial Not Allowed)
Open - Accelerating the Pace of Substance Use Research Using Existing Data (R21 Clinical Trial Not Allowed)
Open - Mechanisms that Impact Cancer Risk after Bariatric Surgery (R21 Clinical Trial Not Allowed)
Open - Dissemination and Implementation Research in Health (R21 Clinical Trial Optional)
Open - Development of Animal Models and Related Biological Materials for Research (R21 Clinical Trial Not Allowed)
Open - Neuromodulation/Neurostimulation Device Development for Mental Health Applications (R21 Clinical Trial Not Allowed)
Open - Mood and Psychosis Symptoms during the Menopause Transition (R21 Clinical Trial Optional)
Open - Utilizing Invasive Recording and Stimulating Opportunities in Humans to Advance Neural Circuitry Understanding of Mental Health Disorders (R21 Clinical Trial Optional)
Open - Exploratory/Developmental Bioengineering Research Grants (EBRG) (R21 Clinical Trial Optional)
Open - Exploratory/Developmental Bioengineering Research Grants (EBRG) (R21 Clinical Trial Not Allowed)
Open - NIH Exploratory/Developmental Research Project Grant (Parent R21 Clinical Trial Not Allowed)
Open - NIH Exploratory/Developmental Research Project Grant (Parent R21 Clinical Trial Required)
Open - Expanding the Target Landscape by Drugging the Undruggable (R21 Clinical Trial Not Allowed)
Open - INCLUDE Project: Exploratory/Developmental Research Awards for Down syndrome (R21 Clinical Trial Not Allowed)
Open - Clinical Trial Readiness for Rare Diseases, Disorders, and Syndromes (R21 Clinical Trial Not Allowed)
Open - Exploratory Grants in Cancer Control (R21 Clinical Trial Optional)
Open - Using Archived Data and Specimen Collections to Advance Maternal and Pediatric HIV/AIDS Research (R21 CT Not Allowed)
Open - Administrative Supplements to Existing NIH Grants and Cooperative Agreements (Parent Admin Supp Clinical Trial Optional)
Open
Forecast R21 notices
Institutes that fund R21 projects under these notices
| Institute or center | Projects |
|---|---|
| National Cancer Institute (NCI) | 1,615 |
| National Institute of Neurological Disorders and Stroke (NINDS) | 1,328 |
| National Institute of Allergy and Infectious Diseases (NIAID) | 1,196 |
| National Institute on Aging (NIA) | 1,037 |
| National Heart Lung and Blood Institute (NHLBI) | 868 |
| National Institute of Mental Health (NIMH) | 675 |
| National Institute of General Medical Sciences (NIGMS) | 642 |
| National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) | 497 |
| Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD) | 491 |
| National Institute on Drug Abuse (NIDA) | 413 |
Closed R21 notices
- PAR-25-037: Cellular and Molecular Biology of Complex Brain Disorders (R21 Clinical Trial Not Allowed)
- PAR-25-040: Schizophrenia and related disorders during mid- to late-life (R21 Clinical Trial Optional)
- PAR-25-066: Social disconnection and Suicide Risk in Late Life (R21 Clinical Trial Optional)
- PAR-25-064: Novel Mechanism Research on Neuropsychiatric Symptoms (NPS) in Alzheimer's Dementia (R21 Clinical Trial Optional)
- PAR-25-229: Investigator Initiated Innovation in Computational Genomics and Data Science (R21 Clinical Trial Not Allowed)
- PAR-25-318: Advancing HIV/AIDS Research within the Mission of the NIDCD (R21 Clinical Trial Optional)
- PAR-25-111: Translational Research in Maternal and Pediatric Pharmacology and Therapeutics (R21 Clinical Trial Optional)
- PAR-25-157: Awards Supporting Cutting-Edge Technologies for Translational Science (ASCETTS) (R21 Clinical Trials Not Allowed)
- RFA-EY-25-001: BRAIN Initiative: New Concepts and Early-Stage Research for Recording and Modulation in the Nervous System (R21) (Clinical Trial Not Allowed)
- PA-25-307: NIH Exploratory/Developmental Research Project Grant (Parent R21 Basic Experimental Studies with Humans Required)
- PAR-25-202: Technology Development Research for Establishing Feasibility and Proof of Concept (R21 - Clinical Trial Not Allowed)
- PA-25-169: Trailblazer Award for New and Early Stage Investigators (R21 Clinical Trial Optional)
- PA-25-150: Joint NINDS/NIMH Exploratory Neuroscience Research Grant (R21 Clinical Trial Not Allowed)
- PAR-25-242: Mobile Health: Technology and Outcomes in Low and Middle Income Countries (R21/R33 - Clinical Trial Optional)
- PAR-24-298: Mechanism for Time-Sensitive Substance Use Research (R21 Clinical Trial Optional)
- RFA-DA-26-010: Mitochondrial-associated Mechanisms of Neuropathological and Immunodeficient Aging in the Context of HIV and SUD (R21 Clinical Trials Not Allowed)
- PAR-25-316: Elucidating Immunometabolic Responses to HIV Infection that Increase TB or HBV Risk (R21 Clinical Trial Not Allowed)
- PAR-25-355: Multidisciplinary Studies of HIV/AIDS and Aging (R21 Clinical Trial Optional)
- PAR-25-199: Engineering Next-Generation Human Nervous System Microphysiological Systems (R21 Clinical Trials Not Allowed)
- PAR-25-083: Co-infection and Cancer (R21 Clinical Trial Not Allowed)
- PAR-25-214: Development of Animal Models and Related Biological Materials for Down Syndrome Research (R21 Clinical Trial Not Allowed)
- PAR-25-056: Secondary Analysis of Existing Datasets in Heart, Lung, and Blood Diseases and Sleep Disorders (R21 Clinical Trial Not Allowed)
- RFA-MH-25-206: Bidirectional Influences Between Adolescent Social Media Use and Mental Health (R21 Clinical Trial Optional)
- PAR-25-220: Leveraging Extant Data to Understand Developmental Trajectories of Late Talking Children (R21 Clinical Trial Not Allowed)
- PAR-25-217: Information and Practice Needs Relevant to Late Talking Children (R21 Clinical Trial Not Allowed)
- RFA-AG-26-014: Aging Mammalian Tissues In Vitro (R21 Clinical Trial Not Allowed)
- PAR-25-230: Ancillary Studies to Ongoing Clinical Projects (R21 Clinical Trial Not Allowed)
- RFA-ES-25-003: Time-Sensitive Research Opportunities in Environmental Health Sciences (R21 Clinical Trials Not Allowed)
- RFA-DA-26-002: Single Cell Opioid Responses in the Context of HIV (SCORCH) Program: Data Mining and Functional Validation (R21 Clinical Trial Not Allowed)
- PAR-25-331: Research on Current Topics in Alzheimer's Disease and Its Related Dementias (R21 Clinical Trial Optional)
- PAR-25-115: Towards a Better Understanding of the Neurological Effects of Infection-Associated Chronic Illnesses (R21 - Clinical Trial Optional)
- RFA-NS-25-025: Exploratory/Developmental Research on Guillain Barre Syndrome (GBS) and Chronic Inflammatory Demyelinating Polyneuropathy (CIDP) (R21 - Clinical Trial Not Allowed)
- PAR-25-139: NCI Clinical and Translational Exploratory/Developmental Studies (R21 Clinical Trial Optional)
- PAR-25-165: Early Stage Investigator HIV/AIDS Research Using Nonhuman Primate (NHP) Models (R21 Clinical Trial Not Allowed)
- PAR-25-128: Biology of Bladder Cancer (R21 Clinical Trial Optional)
- PA-25-295: Innovative Approaches to Studying Cancer Communication in the New Information Ecosystem (R21 Clinical Trial Optional)
- PAR-24-267: Functional Validation and/or Characterization of Genes or Variants Implicated in Substance Use Disorders (R21/R33 Clinical Trial Not Allowed)
- PAR-25-114: CCRP Initiative: NIH Countermeasures Against Chemical Threats (CounterACT) Translational Exploratory/Developmental Research Projects (R21 Clinical Trial Not Allowed)
- PAR-22-199: Precision Approaches in Radiation Synthetic Combinations (PAIRS, R21 Clinical Trial Optional)
- PAR-23-061: Innovations to Optimize HIV Prevention and Care Continuum Outcomes (R21 Clinical Trial Optional)
- PAR-23-111: NIMHD Exploratory/Developmental Research Grant Program (R21 - Clinical Trial Optional)
- PAR-23-191: HIV-associated Non-Communicable Diseases Research at Low- and Middle-Income Country Institutions (R21 Clinical Trial Optional)
- PAR-23-255: Secondary Analysis and Integration of Existing Data to Elucidate Cancer Risk and Related Outcomes (R21 Clinical Trials Not Allowed)
- PAR-23-296: Opportunities for HIV Cure Strategies at the Time of ART Initiation (R21 Clinical Trial Not Allowed)
- PAR-24-111: Understanding Mechanisms and Outcomes of Trained Immunity (R21 Clinical Trial Not Allowed)
- RFA-MH-25-171: BRAIN Initiative: Research on the Ethical Implications of Advancements in Neurotechnology and Brain Science (R21 Clinical Trial Optional)
- PAR-22-231: NINR Areas of Emphasis for Research to Optimize Health and Advance Health for All (R21 Clinical Trial Optional)
- PA-25-123: Epidemiologic Research on Emerging Risk Factors and Liver Cancer Susceptibility (R21 Clinical Trial Not Allowed)
- PAR-25-108: Microbial-based Cancer Imaging and Therapy - Bugs as Drugs (R21 Clinical Trial Not Allowed)
- PA-25-173: Systematic Testing of Radionuclides in Preclinical Experiments (STRIPE) (R21 Clinical Trial Not Allowed)
- PAR-23-299: Intervention Research to Improve Native American Health (R21 Clinical Trials Optional)
- PAR-25-152: Impacts of climate change across the cancer control continuum (R21 Clinical Trial Optional)
- RFA-MH-26-111: Role of T-Cells in HIV CNS Reservoir Seeding, Persistence, and Neuropathogenesis (R21 Clinical Trial Not Allowed)
- RFA-HG-23-018: Investigator-Initiated Research in Genomics and Health Equity (R21 Clinical Trial Optional)
- RFA-DA-26-008: Advancing Research on Molecular Targets and Mechanisms that Influence the Interplay Between Sex Hormones, HIV, and Addictive Substances (R21 Clinical Trials Not Allowed)
- RFA-DA-25-068: Targeting Inflammasomes in HIV and Substance Use (R21 Clinical Trial Not Allowed)
- PAR-25-241: Tobacco, Alcohol, and Cannabis Policy Research for Health Equity (R21 Clinical Trial Optional)
- PA-23-189: Research Supplements to Promote Diversity in Health-Related Research (Admin Supp Clinical Trial Not Allowed)
- PAR-24-039: Exploratory Grant Award to Promote Workforce Diversity in Basic Cancer Research (R21 Clinical Trial Not Allowed)
- PAR-25-097: Small Grants for New Investigators to Broaden Participation in Health-Related Research (R21 Clinical Trial Optional)
- RFA-HG-25-003: Advancing Genomic Medicine Research (R21 Clinical Trial Optional)
- RFA-AI-24-068: New Therapeutic Strategies for Genital Herpes (R21/R33 Clinical Trial Not Allowed)
- RFA-AI-24-065: Discovery and Development of Novel Therapeutics for Select Fungal Pathogens (R21/R33 Clinical Trial Not Allowed)
- RFA-EB-23-005: Research on Bioethical Issues Related to Bionic and Robotic Device Development and Translation (R21 Clinical Trial Optional)
- PAR-22-027: Mechanism for Time-Sensitive Drug Abuse Research (R21 Clinical Trial Optional)
- PAR-23-294: Ethical, Legal and Social Implications (ELSI) Exploratory/Developmental Research Grant (R21 Clinical Trial Optional)
- PAR-24-026: Schizophrenia and related disorders during mid- to late-life (R21 Clinical Trial Optional)
- PAR-24-025: Cellular and Molecular Biology of Complex Brain Disorders (R21 Clinical Trial Not Allowed)
- PAR-21-176: Understanding and Modifying Temporal Dynamics of Coordinated Neural Activity (R21 Clinical Trial Optional)
- PA-21-235: NIMH Exploratory/Developmental Research Grant (R21 Clinical Trial Not Allowed)
- PA-21-219: Joint NINDS/NIMH Exploratory Neuroscience Research Grant (R21 Clinical Trial Optional)
- PAR-21-255: Investigator Initiated Research in Computational Genomics and Data Science (R21 Clinical Trial Not Allowed)
- PAR-21-313: Small Grants for New Investigators to Promote Diversity in Health-Related Research (R21 Clinical Trial Optional)
- PAR-22-038: Neuromodulation/Neurostimulation Device Development for Mental Health Applications (R21 Clinical Trial Not Allowed)
- PAR-22-062: Modulating Human Microbiome Function to Enhance Immune Responses Against Cancer (R21 Clinical Trial Not Allowed)
- PAR-22-032: Drug Discovery For Nervous System Disorders (R21 Clinical Trials Not Allowed)
- PAR-22-067: Basic Neurodevelopmental Biology of Circuits and Behavior (R21 Clinical Trial Not Allowed)
- PAR-22-138: Accelerating the Pace of Child Health Research Using Existing Data from the Adolescent Brain Cognitive Development (ABCD) Study (R21-Clinical Trial Not Allowed)
- PAR-22-109: Dissemination and Implementation Research in Health (R21 Clinical Trial Optional)
- PAR-24-022: Trailblazer Award for New and Early Stage Investigators (R21 Clinical Trial Optional)
- PAR-23-036: Secondary Analysis of Existing Datasets in Heart, Lung, and Blood Diseases and Sleep Disorders (R21 Clinical Trial Not Allowed)
- PAR-23-101: Utilizing Invasive Recording and Stimulating Opportunities in Humans to Advance Neural Circuitry Understanding of Mental Health Disorders (R21 Clinical Trial Optional)
- PAR-23-106: Advancing HIV/AIDS Research within the Mission of the NIDCD (R21 Clinical Trial Optional)
- PAR-23-119: Catalytic Tool and Technology Development in Kidney, Urologic, and Hematologic Diseases (R21 Clinical Trial Not Allowed)
- PAR-24-092: Multidisciplinary Studies of HIV/AIDS and Aging (R21 Clinical Trial Optional)
- PAR-24-162: Pilot Studies of Biological, Behavioral and Social Mechanisms Contributing to HIV Pathogenesis Within the Mission of NIDDK (R21 Clinical Trial Not Allowed)
- PAR-23-208: Novel Mechanism Research on Neuropsychiatric Symptoms (NPS) in Alzheimer's Dementia (R21 Clinical Trial Optional)
- PAR-22-141: NEI Research Grant for Vision-Related Secondary Data Analysis (R21 Clinical Trial Not Allowed)
- PAR-22-091: Exploratory/Developmental Bioengineering Research Grants (EBRG) (R21 Clinical Trial Optional)
- PAR-22-090: Exploratory/Developmental Bioengineering Research Grants (EBRG) (R21 Clinical Trial Not Allowed)
- RFA-HL-23-018: Maximizing the Scientific Value of the NHLBI Biologic Biospecimen Repository: Scientific Opportunities for Exploratory Research (R21)
- PAR-23-177: Awards Supporting Cutting-Edge Technologies for Translational Science (ASCETTS) (R21 Clinical Trials Not Allowed)
- RFA-CA-25-012: The Confluence of Cancer Stigma and HIV Stigma in HIV-positive Individuals Diagnosed with Cancer (R21 Clinical Trial Optional)
- PAR-22-098: Global Brain and Nervous System Disorders Research Across the Lifespan (R21 Clinical Trial Optional)
- PAR-23-026: Ancillary Studies to Ongoing Clinical Projects (R21 Clinical Trial Not Allowed)
- RFA-EY-23-001: BRAIN Initiative: New Concepts and Early-Stage Research for Recording and Modulation in the Nervous System (R21) (Clinical Trial Not Allowed)
- PAR-22-186: Transgender People: Immunity, Prevention, and Treatment of HIV and STIs (R21 Clinical Trial Not Allowed)
- RFA-TR-24-023: Preclinical Proof of Concept Studies for Rare Diseases (R21 Clinical Trial Not Allowed)
- RFA-AI-24-064: Strategies for Eliminating HIV Proteins (R21 Clinical Trial Not Allowed)
- PAR-23-318: Mobile Health: Technology and Outcomes in Low and Middle Income Countries (R21/R33 - Clinical Trial Optional)
Questions people ask
What is an NIH R21?
R21 is NIH's activity code for the Exploratory/Developmental Research Grant. Early, exploratory ideas that may not have preliminary data yet, usually for up to two years. Each notice sets its own budget limit, project length and due dates.
How many NIH R21 funding opportunities are open?
33 notices are open on Grants.gov, and 1 more is forecast, as of the latest data.