PAR-25-229: Investigator Initiated Innovation in Computational Genomics and Data Science (R21 Clinical Trial Not Allowed)
Closed
This grant is closed. Who won this program's grants before is below, and similar open grants are at the end of the page. It is in our archive of National Institutes of Health notices from 2024.
National Institutes of Health offered grants to nonprofits, colleges and universities, state and local governments, tribes, small businesses and businesses. Applications closed on September 4, 2026.
From the official notice on Grants.gov, last changed September 4, 2026. Checked November 7, 2026.
- Award amountsNot given on Grants.gov
- Cost sharingNot required
- Funding typeGrant
About this NIH notice
- Activity codeR21
- Clinical trialsNot allowed
- Funded byNHGRI, NLM
- Median yearly award$321,004
- Typical project length2 years
- R21, Exploratory/Developmental Research Grant. Early, exploratory ideas that may not have preliminary data yet, usually for up to two years. Other open R21 notices.
Projects funded under PAR-25-229 were run by National Human Genome Research Institute (NHGRI, 1 project) and National Library of Medicine (NLM, 1 project). Contact the program officer at the institute that fits your project before you apply; the notice lists them.
Application due dates, page limits and budget limits are set in the notice. Read PAR-25-229 in the NIH Guide.
Key dates
| Posted | November 18, 2024 |
|---|---|
| Deadline | September 4, 2026 |
| Archived by Grants.gov | October 4, 2026 |
Who can apply
This opportunity was open to nonprofits, colleges and universities, state and local governments, tribes, small businesses and businesses.
All 15 applicant types the notice lists
- State governments
- County governments
- City or township governments
- Special district governments
- Independent school districts
- Public and State controlled institutions of higher education
- Native American tribal governments (Federally recognized)
- Public housing authorities/Indian housing authorities
- Native American tribal organizations (other than Federally recognized tribal governments)
- Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education
- Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education
- Private institutions of higher education
- For profit organizations other than small businesses
- Small businesses
- Others (see text field entitled "Additional Information on Eligibility" for clarification)
Other Eligible Applicants include the following: Alaska Native and Native Hawaiian Serving Institutions; Asian American Native American Pacific Islander Serving Institutions (AANAPISISs); Eligible Agencies of the Federal Government; Faith-based or Community-based Organizations; Hispanic-serving Institutions; Historically Black Colleges and Universities (HBCUs); Indian/Native American Tribal Governments (Other than Federally Recognized); Non-domestic (non-U.S.) Entities (Foreign Organizations); Regional Organizations; Tribally Controlled Colleges and Universities (TCCUs) ; U.S. Territory or Possession.
Is this a realistic fit?
- Most of the money in the 2 programs behind this notice (69% over five years) went to colleges and universities.
- No cost sharing or match is required.
What the grant funds
The purpose of this funding opportunity announcement (FOA) is to invite applications for a broad range of research efforts in computational genomics, data science, statistics, and bioinformatics relevant to one or both of basic or clinical genomic science, and broadly applicable to human health and disease. This FOA supports fundamental genomics research developing innovative analytical methodologies and approaches, early-stage development of tools and software, and refinement or hardening of software and tools of high value to the biomedical genomics community. Work supported under this FOA should be enabling for genomics and be generalizable or broadly applicable across diseases and biological systems. All applications should address how the methods would scale to address increasingly larger data sets.
Funded under PAR-25-229 so far
NIH funded 2 projects under PAR-25-229 in fiscal 2026, at 2 institutions. The median yearly award was $321,004.
| Project | Institution | Fiscal year | Award |
|---|---|---|---|
| Sensitive and Accurate Quantification Of Small RNAs At Single-nucleotide Resolution From Deep Sequencing Data | Thomas Jefferson University | 2026 | $431,750 |
| Artificial intelligence-enhanced prediction of neuropeptides | University of Illinois at Urbana-Champaign | 2026 | $210,258 |
Who has won Human Genome Research grants before
From fiscal 2021 to 2025, Human Genome Research (93.172) awarded $2.2 billion across 1,255 grant awards, an average of $1.7 million per award.
| Recipient | State | Awards | Amount |
|---|---|---|---|
| The Leland Stanford Junior University | California | 59 | $153 million |
| University of Washington | Washington | 46 | $123 million |
| The Broad Institute, Inc | Massachusetts | 22 | $119 million |
| University of California Santa Cruz | California | 17 | $64.7 million |
| Baylor College of Medicine | Texas | 24 | $62.9 million |
Who has won Medical Library Assistance grants before
From fiscal 2021 to 2025, Medical Library Assistance (93.879) awarded $353 million across 391 grant awards, an average of $902,940 per award.
| Recipient | State | Awards | Amount |
|---|---|---|---|
| The Leland Stanford Junior University | California | 20 | $22.3 million |
| University of Washington | Washington | 12 | $13.6 million |
| University of Pittsburgh - of the Commonwealth System of Higher Education | Pennsylvania | 17 | $13.6 million |
| Yale Univ | Connecticut | 10 | $13.3 million |
| University of Utah | Utah | 4 | $13.2 million |
Applying now
This notice no longer takes applications. Agencies often post the same opportunity again under a new number, so check the program's notices on Grants.gov and the similar open grants below.
The notice on Grants.gov keeps its full text and attachments, which is useful for planning a resubmission.
Questions people ask
Is PAR-25-229 still open?
No. It closed on September 4, 2026.
Who can apply for Investigator Initiated Innovation in Computational Genomics and Data Science (R21 Clinical Trial Not Allowed)?
National Institutes of Health accepted applications from nonprofits, colleges and universities, state and local governments, tribes, small businesses and businesses. The notice adds further conditions, so read its eligibility section.
What is the deadline for Investigator Initiated Innovation in Computational Genomics and Data Science (R21 Clinical Trial Not Allowed)?
Closed September 4, 2026. Applications are no longer accepted; the program's newer notices are on this page when there are any.
Who has been funded under PAR-25-229?
NIH RePORTER lists 2 projects funded under PAR-25-229 in fiscal 2026, at 2 institutions. The most were at Thomas Jefferson University, University of Illinois at Urbana-Champaign.
Who has won Human Genome Research grants before?
The largest recipients over five fiscal years were The Leland Stanford Junior University, University of Washington, The Broad Institute, Inc. The program made 1,255 awards worth $2.2 billion in that time.
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