PAR-25-230: Ancillary Studies to Ongoing Clinical Projects (R21 Clinical Trial Not Allowed)
Closed
This grant is closed. Who won this program's grants before is below, and similar open grants are at the end of the page. It is in our archive of National Institutes of Health notices from 2024.
National Institutes of Health offered grants of up to $250,000 to nonprofits, colleges and universities, state and local governments, tribes, small businesses and businesses. It expected to make $250,000 in total. Applications closed on December 5, 2025.
From the official notice on Grants.gov, last changed December 9, 2024. Checked November 7, 2026.
- Award ceiling$250,000
- Total funding$250,000
- Cost sharingNot required
- Funding typeGrant
About this NIH notice
- Activity codeR21
- Clinical trialsNot allowed
- Funded byNIAMS
- Median yearly award$538,553
- Typical project length2 years
- R21, Exploratory/Developmental Research Grant. Early, exploratory ideas that may not have preliminary data yet, usually for up to two years. Other open R21 notices.
Projects funded under PAR-25-230 were run by National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS, 2 projects). Contact the program officer at the institute that fits your project before you apply; the notice lists them.
This notice replaced PAR-23-026.
Application due dates, page limits and budget limits are set in the notice. Read PAR-25-230 in the NIH Guide.
Other notices with this title
| Notice | Posted | Deadline | Status |
|---|---|---|---|
| PAR-23-026 | November 21, 2022 | Closed December 8, 2024 | Closed |
Key dates
| Posted | December 9, 2024 |
|---|---|
| Deadline | December 5, 2025 |
| Archived by Grants.gov | January 10, 2026 |
Who can apply
This opportunity was open to nonprofits, colleges and universities, state and local governments, tribes, small businesses and businesses.
All 15 applicant types the notice lists
- State governments
- County governments
- City or township governments
- Special district governments
- Independent school districts
- Public and State controlled institutions of higher education
- Native American tribal governments (Federally recognized)
- Public housing authorities/Indian housing authorities
- Native American tribal organizations (other than Federally recognized tribal governments)
- Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education
- Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education
- Private institutions of higher education
- For profit organizations other than small businesses
- Small businesses
- Others (see text field entitled "Additional Information on Eligibility" for clarification)
Other Eligible Applicants include the following: Alaska Native and Native Hawaiian Serving Institutions; Asian American Native American Pacific Islander Serving Institutions (AANAPISISs); Eligible Agencies of the Federal Government; Faith-based or Community-based Organizations; Hispanic-serving Institutions; Historically Black Colleges and Universities (HBCUs); Indian/Native American Tribal Governments (Other than Federally Recognized); Non-domestic (non-U.S.) Entities (Foreign Organizations); Regional Organizations; Tribally Controlled Colleges and Universities (TCCUs) ; U.S. Territory or Possession; Non-domestic (non-U.S.) Entities (Foreign Organizations) are not eligible to apply. Non-domestic (non-U.S.) components of U.S. Organizations are not eligible to apply.
Is this a realistic fit?
- Projects NIH funded under this notice had a median yearly award of $538,553; it allows up to $250,000 per award.
- Most of the program's money (74% over five years) went to colleges and universities.
- No cost sharing or match is required.
What the grant funds
This Ancillary Studies to Ongoing Clinical Projects (R21 Clinical Trial Not Allowed) PAR, a re-issue of PAR-23-026, was re-issued as a result of the Simplifying Review of Research Project Grant Applications [link: https://grants.nih.gov/policy-and-compliance/policy-topics/peer-review/simplifying-review]. The Simplified Review changes in Section V are the only changes that have been made. All other aspects of this funding opportunity remain the same.
Funded under PAR-25-230 so far
NIH funded 2 projects under PAR-25-230 in fiscal 2026, at 2 institutions. The median yearly award was $538,553.
| Project | Institution | Fiscal year | Award |
|---|---|---|---|
| Scalable imaging approach to measure muscle bioenergetics in CKD. | Albert Einstein College of Medicine | 2026 | $556,651 |
| Smart Sleeve for Rehabilitation Monitoring Following ACL Reconstruction | Carnegie-Mellon University | 2026 | $520,455 |
Who has won Arthritis, Musculoskeletal and Skin Diseases Research grants before
From fiscal 2021 to 2025, Arthritis, Musculoskeletal and Skin Diseases Research (93.846) awarded $2.6 billion across 2,897 grant awards, an average of $908,766 per award.
| Recipient | State | Awards | Amount |
|---|---|---|---|
| The Trustees of the University of Pennsylvania | Pennsylvania | 104 | $104 million |
| Brigham & Womens Hospital Inc | Massachusetts | 89 | $95.7 million |
| The Regents of the University of California, San Francisco | California | 84 | $93.3 million |
| The Washington University | Missouri | 88 | $72.4 million |
| Regents of the University of Michigan | Michigan | 73 | $68.0 million |
Applying now
This notice no longer takes applications. Agencies often post the same opportunity again under a new number, so check the program's notices on Grants.gov and the similar open grants below.
The notice on Grants.gov keeps its full text and attachments, which is useful for planning a resubmission.
Questions people ask
Is PAR-25-230 still open?
No. It closed on December 5, 2025.
Who can apply for Ancillary Studies to Ongoing Clinical Projects (R21 Clinical Trial Not Allowed)?
National Institutes of Health accepted applications from nonprofits, colleges and universities, state and local governments, tribes, small businesses and businesses. The notice adds further conditions, so read its eligibility section.
What is the deadline for Ancillary Studies to Ongoing Clinical Projects (R21 Clinical Trial Not Allowed)?
Closed December 5, 2025. Applications are no longer accepted; the program's newer notices are on this page when there are any.
How much funding is available?
Awards of up to $250,000 each. About $250,000 in total.
Who has been funded under PAR-25-230?
NIH RePORTER lists 2 projects funded under PAR-25-230 in fiscal 2026, at 2 institutions. The most were at Albert Einstein College of Medicine, Carnegie-Mellon University.
Who has won Arthritis, Musculoskeletal and Skin Diseases Research grants before?
The largest recipients over five fiscal years were The Trustees of the University of Pennsylvania, Brigham & Womens Hospital Inc, The Regents of the University of California, San Francisco. The program made 2,897 awards worth $2.6 billion in that time.
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