PAR-21-127: Shared Instrumentation Grant (SIG) Program (S10 Clinical Trial Not Allowed)
Closed
This grant is closed. A newer notice from the same program is open now: Shared Instrumentation Grant (SIG) Program (S10 Clinical Trial Not Allowed) (PAR-27-022). Status: Due dates in the notice, expires July 1, 2028. It is in our archive of National Institutes of Health notices from 2021.
National Institutes of Health offered grants of up to $600,000 to nonprofits and colleges and universities. It expected to make about 75 awards worth $35.0 million in total. Applications closed on June 15, 2021.
From the official notice on Grants.gov, last changed May 27, 2021. Checked November 7, 2026.
- Award ceiling$600,000
- Total funding$35.0 million
- Expected awards75
- Cost sharingNot required
- Funding typeGrant
About this NIH notice
- Activity codeS10
- Clinical trialsNot allowed
- Funded byOD
- Median yearly award$513,853
- Typical project length1 year
- S10, Shared Instrumentation Grant. Expensive research instruments shared by several NIH-funded investigators. Other open S10 notices.
Projects funded under PAR-21-127 were run by NIH Office of the Director (OD, 96 projects). Contact the program officer at the institute that fits your project before you apply; the notice lists them.
Application due dates, page limits and budget limits are set in the notice. Read PAR-21-127 in the NIH Guide.
Other notices with this title
| Notice | Posted | Deadline | Status |
|---|---|---|---|
| PAR-27-022 | June 25, 2026 | Due dates in the notice, expires July 1, 2028 | Open |
| PAR-24-265 | October 29, 2024 | Closed July 16, 2026 | Closed |
| PAR-22-080 | January 7, 2022 | Closed June 3, 2024 | Closed |
Key dates
| Posted | February 8, 2021 |
|---|---|
| Deadline | June 15, 2021 |
| Archived by Grants.gov | July 15, 2021 |
Who can apply
This opportunity was open to nonprofits and colleges and universities.
- Public and State controlled institutions of higher education
- Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education
- Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education
- Private institutions of higher education
- Others (see text field entitled "Additional Information on Eligibility" for clarification)
Other Eligible Applicants include the following: Alaska Native and Native Hawaiian Serving Institutions; Asian American Native American Pacific Islander Serving Institutions (AANAPISISs); Hispanic-serving Institutions; Historically Black Colleges and Universities (HBCUs); Tribally Controlled Colleges and Universities (TCCUs) ; U.S. Territory or Possession; Non-domestic (non-U.S.) Entities (Foreign Institutions) are not eligible to apply. Non-domestic (non-U.S.) components of U.S. Organizations are not eligible to apply. Foreign components, as defined in the NIH Grants Policy Statement, are not allowed.
Is this a realistic fit?
- Projects NIH funded under this notice had a median yearly award of $513,853; it allows up to $600,000 per award.
- Most of the money in the 2 programs behind this notice (80% over five years) went to colleges and universities.
- No cost sharing or match is required.
What the grant funds
The Shared Instrument Grant (SIG) Program encourages applications from groups of NIH-supported investigators to purchase or upgrade a single item of high-priced, specialized, commercially available instruments or integrated instrumentation system. The minimum award is $50,000. There is no maximum price limit for the instrument; however, the maximum award is $600,000. Instruments supported include, but are not limited to: X-ray diffractometers, mass spectrometers, nuclear magnetic resonance spectrometers, DNA and protein sequencers, biosensors, electron and light microscopes, cell sorters, and biomedical imagers.
Funded under PAR-21-127 so far
NIH funded 96 projects under PAR-21-127 in fiscal 2022, at 63 institutions. The median yearly award was $513,853.
| Project | Institution | Fiscal year | Award |
|---|---|---|---|
| Inductively Coupled Plasma Mass Spectrometer | Massachusetts General Hospital | 2022 | $598,359 |
| 3D Printer | Medical College of Wisconsin | 2022 | $77,425 |
| High Sensitivity sCMOS Camera System for Transmission Electron Microscope | Washington University | 2022 | $147,000 |
| Development of an Integrated Intermediary Metabolomics and Metabolic Flux Core | Yale University | 2022 | $366,335 |
| Fred Hutch Preclinical Ultrasound | Fred Hutchinson Cancer Center | 2022 | $373,050 |
| Laser Scanning Vibrometer | University of California-Irvine | 2022 | $600,000 |
| BD FACSymphony A5 Cell Analyzer | University of South Carolina at Columbia | 2022 | $513,281 |
| High-Throughput Automated Patch Clamp System | University of Texas HLTH Sci Ctr Houston | 2022 | $599,014 |
Who has won Biomedical Research and Research Training grants before
From fiscal 2021 to 2025, Biomedical Research and Research Training (93.859) awarded $15 billion across 11,631 grant awards, an average of $1.3 million per award.
| Recipient | State | Awards | Amount |
|---|---|---|---|
| The Leland Stanford Junior University | California | 186 | $290 million |
| Regents of the University of Michigan | Michigan | 226 | $268 million |
| University of California, San Diego | California | 198 | $264 million |
| Yale Univ | Connecticut | 195 | $250 million |
| University of Wisconsin System | Wisconsin | 169 | $241 million |
Who has won Research Infrastructure Programs grants before
From fiscal 2021 to 2025, Research Infrastructure Programs (93.351) awarded $1.4 billion across 1,102 grant awards, an average of $1.3 million per award.
| Recipient | State | Awards | Amount |
|---|---|---|---|
| University of California, Davis | California | 27 | $102 million |
| Oregon Health & Science University | Oregon | 18 | $92.1 million |
| University of Washington | Washington | 7 | $79.5 million |
| Emory University | Georgia | 14 | $78.3 million |
| The Administrators of Tulane Educational Fund | Louisiana | 10 | $68.0 million |
Applying now
This notice no longer takes applications. Apply under the newer notice, PAR-27-022, which is open now.
The notice on Grants.gov keeps its full text and attachments, which is useful for planning a resubmission.
Questions people ask
Is PAR-21-127 still open?
No. It closed on June 15, 2021. A newer notice is open: PAR-27-022, due dates in the notice, expires July 1, 2028.
Who can apply for Shared Instrumentation Grant (SIG) Program (S10 Clinical Trial Not Allowed)?
National Institutes of Health accepted applications from nonprofits and colleges and universities. The notice adds further conditions, so read its eligibility section.
What is the deadline for Shared Instrumentation Grant (SIG) Program (S10 Clinical Trial Not Allowed)?
Closed June 15, 2021. Applications are no longer accepted; the program's newer notices are on this page when there are any.
How much funding is available?
Awards of up to $600,000 each. About $35.0 million in total across about 75 awards.
Who has been funded under PAR-21-127?
NIH RePORTER lists 96 projects funded under PAR-21-127 in fiscal 2022, at 63 institutions. The most were at University of California, San Diego, Washington University, Univ of North Carolina Chapel Hill.
Who has won Research Infrastructure Programs grants before?
The largest recipients over five fiscal years were University of California, Davis, Oregon Health & Science University, University of Washington. The program made 1,102 awards worth $1.4 billion in that time.
Similar open grants
- Shared Instrumentation Grant (SIG) Program (S10 Clinical Trial Not Allowed)
- Seed Instrumentation Support (SIS) Program (S10 Clinical Trial Not Allowed)
- Limited Competition: Instrumentation Grant Program for Resource-Limited Institutions (S10 - Clinical Trial Not Allowed)
- Single Source for the Continuation of the Caring for OutPatiEnts after Acute Kidney Injury (COPE-AKI) Scientific and Data Research Center (U01 Clinical Trial Required)
- Single Source for the Continuation of the Epidemiology of Diabetes Interventions and Complications (EDIC) Study Research Center (Collaborative U01 Clinical Trial Not Allowed)
- Data Coordinating Center for the Aging and Alzheimer’s Disease Mouse Brain Atlas (AD-MBA) (U24 Clinical Trial Not Allowed)