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Grants / Department of Health and Human Services / National Institutes of Health

Shared Instrumentation Grant (SIG) Program (S10 Clinical Trial Not Allowed)

Open Closes July 1, 2028 (609 days left) Opportunity PAR-27-022

National Institutes of Health is offering grants of up to $5.0 million (at least $300,000) to nonprofits, colleges and universities, state and local governments, tribes, small businesses and businesses. Applications close on July 1, 2028.

From the official notice on Grants.gov, last changed June 25, 2026. Checked October 31, 2026.

Key dates

PostedJune 25, 2026
DeadlineJuly 1, 2028
Archived by Grants.govAugust 30, 2028

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Who can apply

This opportunity is open to nonprofits, colleges and universities, state and local governments, tribes, small businesses and businesses.

Refer to Section III. Eligibility Information in the NOFO for additional information on eligibility. Foreign Organizations/Foreign Collaborations:Non-domestic (non-U.S.) Entities (Foreign Organizations) are not eligible to apply. Non-domestic (non-U.S.) components of U.S. Organizations are not eligible to apply. Foreign components, as defined in the NIH Grants Policy Statement, are not allowed.

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Is this a realistic fit?

What the grant funds

This Notice of Funding Opportunity (NOFO) announces the restructured Shared Instrumentation Grant (SIG) Program that consolidates three existing shared-use instrumentation programs, i.e., the Shared Instrumentation Grant program, the High-End Instrumentation Grant program, and the Basic Instrumentation Grant program. The NOFO invites applications from groups of NIH-supported investigators to purchase or upgrade a single state-of-the-art commercially available instrument or an integrated instrumentation system. The instruments purchased through the SIG Program are required to be optimally shared among the users to ensure efficient and cost-effective research operations, enable rigorous and reproducible measurements, and encourage collaborative research and benefit broad research communities at large. The minimum award is $300,000. There is no cap on the total cost of the instrument; however, the maximum award is $5,000,000. Cost sharing is required for premium instruments or special use instruments.

Category: Health.

How to apply

  1. Read the full notice and attachments on Grants.gov. The notice is the official source for deadlines and requirements.
  2. Make sure your organization has an active SAM.gov registration and Unique Entity ID; registration can take several weeks.
  3. Register on Grants.gov and submit through Workspace before the deadline and time given in the notice. Our application guide walks through each step.

Questions go to National Institutes of Health, odsig@mail.nih.gov, 301-402-2541.

Open the official notice

Questions people ask

Who can apply for Shared Instrumentation Grant (SIG) Program (S10 Clinical Trial Not Allowed)?

National Institutes of Health accepts applications from nonprofits, colleges and universities, state and local governments, tribes, small businesses and businesses. The notice adds further conditions, so read its eligibility section.

What is the deadline for Shared Instrumentation Grant (SIG) Program (S10 Clinical Trial Not Allowed)?

Closes July 1, 2028 (609 days left). Confirm the date and time in the official notice on Grants.gov.

How much funding is available?

Awards of up to $5.0 million each.

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