Seed Instrumentation Support (SIS) Program (S10 Clinical Trial Not Allowed)
Open
National Institutes of Health is offering grants of up to $400,000 (at least $50,000) to nonprofits, colleges and universities, state and local governments, tribes, small businesses and businesses. Applications close on July 1, 2028.
From the official notice on Grants.gov, last changed June 25, 2026. Checked October 31, 2026.
- Award ceiling$400,000
- Award floor$50,000
- Expected awardsnot stated
- Total fundingnot stated
- Cost sharingNot required
- Funding typeGrant
Key dates
| Posted | June 25, 2026 |
|---|---|
| Deadline | July 1, 2028 |
| Archived by Grants.gov | September 1, 2028 |
Add the deadline to your calendar
Who can apply
This opportunity is open to nonprofits, colleges and universities, state and local governments, tribes, small businesses and businesses.
- State governments
- County governments
- City or township governments
- Special district governments
- Independent school districts
- Public and State controlled institutions of higher education
- Native American tribal governments (Federally recognized)
- Public housing authorities/Indian housing authorities
- Native American tribal organizations (other than Federally recognized tribal governments)
- Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education
- Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education
- Private institutions of higher education
- For profit organizations other than small businesses
- Small businesses
- Others (see text field entitled "Additional Information on Eligibility" for clarification)
Refer to Section III. Eligibility Information in the NOFO for additional information on eligibility. Foreign Organizations/Foreign Collaborations:Non-domestic (non-U.S.) Entities (Foreign Organizations) are not eligible to apply. Non-domestic (non-U.S.) components of U.S. Organizations are not eligible to apply. Foreign components, as defined in the NIH Grants Policy Statement, are not allowed.
Is this a realistic fit?
- No cost sharing or match is required.
What the grant funds
This Notice of Funding Opportunity (NOFO) aims to build new research capacity and develop a sustainable research program by supporting the purchase of a single commercially available biomedical research instrument currently unavailable in the institution. Instruments funded through this program must be shared among the users to create new research opportunities, enable reproducible data generation, encourage collaborative research and training, and strengthen long-term research capabilities. The minimum award is $50,000. While there is no limit on the total cost of the instrument, the maximum award is $400,000.
How to apply
- Read the full notice and attachments on Grants.gov. The notice is the official source for deadlines and requirements.
- Make sure your organization has an active SAM.gov registration and Unique Entity ID; registration can take several weeks.
- Register on Grants.gov and submit through Workspace before the deadline and time given in the notice. Our application guide walks through each step.
Questions go to National Institutes of Health, odsig@mail.nih.gov, 301-402-2541.
Questions people ask
Who can apply for Seed Instrumentation Support (SIS) Program (S10 Clinical Trial Not Allowed)?
National Institutes of Health accepts applications from nonprofits, colleges and universities, state and local governments, tribes, small businesses and businesses. The notice adds further conditions, so read its eligibility section.
What is the deadline for Seed Instrumentation Support (SIS) Program (S10 Clinical Trial Not Allowed)?
Closes July 1, 2028 (609 days left). Confirm the date and time in the official notice on Grants.gov.
How much funding is available?
Awards of up to $400,000 each.
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