Research Infrastructure Programs (93.351)
Research Infrastructure Programs (Assistance Listing 93.351) is run by the National Institutes of Health, part of the Department of Health and Human Services. It awarded $1.4 billion in 1,102 grants from fiscal 2021 to 2025, about $1.3 million per award on average. 29 funding opportunities are open or forecast now.
The typical award was $493,058. Half of the 1,102 awards fell between $246,170 and $1.0 million, and they ranged from $1 to $66.8 million.
- Awarded, FY 2021 to 2025$1.4 billion
- Grant awards1,102
- Typical award$493,058
- Awarded in FY 2025$281 million
- Size rank215 of 1824
- Type of assistanceProject grants
Key findings
- Annual funding was roughly flat, $272 million in fiscal 2021 and $281 million in fiscal 2025.
- It is the 215th largest of 1,824 federal grant programs by five-year awards.
- The 20 largest recipients received 59% of the money.
- Awards went to recipients in 50 states and territories.
What the program funds
The Office of Research Infrastructure Programs (ORIP) is a program office in the Division of Program Coordination, Planning, and Strategic Initiatives (DPCPSI) dedicated to supporting research infrastructure and related research resource programs. ORIP consists of the Division of Comparative Medicine (DCM) and the Division of Construction and Instruments (DCI).
Open opportunities
- NIH, CDC and FDA Small Business Innovation Research Grant (Parent SBIR [R43/R44] Clinical Trial Optional)
- NIH Small Business Technology Transfer Grant (Parent STTR [R41/R42] Clinical Trial Optional)
- Mentored Research Scientist Development Award (Parent K01 - Independent Clinical Trial Not Allowed)
- Change of Recipient Organization (Type 7 Parent Clinical Trial Optional)
- Successor-in-Interest (Type 6 Parent Clinical Trial Optional)
- Screening and Functional Validation of Genomic Variants Associated with Human Congenital Anomalies (R01 Clinical Trial Not Allowed)
- Development of Animal Models and Related Biological Materials for Research (R21 Clinical Trial Not Allowed)
- Research Enhancement Award Program (REAP) for Health Professional Schools and Graduate Schools (R15 Clinical Trial Not Allowed)
- NIH Research Project Grant (Parent R01 Clinical Trial Not Allowed)
- Ruth L. Kirschstein National Research Service Award (NRSA) Institutional Research Training Grant (Parent T32)
- Ruth L. Kirschstein National Research Service Award (NRSA) Short-Term Institutional Research Training Grant (Parent T35)
- INCLUDE Project: Exploratory/Developmental Research Awards for Down syndrome (R21 Clinical Trial Not Allowed)
- INCLUDE Project: Transformative Research Awards for Down syndrome (R01 Clinical Trial Not Allowed)
- Shared Instrumentation Grant (SIG) Program (S10 Clinical Trial Not Allowed)
- Seed Instrumentation Support (SIS) Program (S10 Clinical Trial Not Allowed)
- Stephen I. Katz Early Stage Investigator Research Project Grant (R01 Clinical Trial Not Allowed)
- Animal and Biological Material Resource Centers (P40 Clinical Trial Not Allowed)
- Resource-Related Research Projects for Development of Models and Related Materials for Studying Human Health and Diseases (R24 Clinical Trials Not Allowed)
- Administrative Supplements to Existing NIH Grants and Cooperative Agreements (Parent Admin Supp Clinical Trial Optional)
- Limited Competition: Instrumentation Grant Program for Resource-Limited Institutions (S10 - Clinical Trial Not Allowed)
- SBIR/STTR Commercialization Readiness Pilot (CRP) Program (Parent SB1 Clinical Trial Optional)
- NIH Small Business Innovation Research (SBIR) Phase IIB Strategic Breakthrough Award (Parent [R44] Clinical Trial Optional)
- NIH Collaborative International Research Project (Parent PF5 Clinical Trial Optional)
- Research Resource for a National Swine Resource and Research Center (U42 Clinical Trial Not Allowed)
- National Biomedical Research Centers (P50 Clinical Trial Optional)
Rules from the program listing
Who can apply
Institutions of higher education, hospitals, and other institutions and organizations, both nonprofit and for-profit, seeking to establish, continue, or enlarge programs consistent with the objectives of the program. To be eligible for instrumentation and equipment programs, applications must be Private nonprofit institutions/organizations, Public nonprofit institutions/organizations. Applicants for NRSA must be citizens of the United States or be admitted to the United States for permanent residency. Applicants must be nominated and sponsored by a public or private nonprofit institution with staff and facilities suitable for the proposed research training. Nonprofit domestic organizations may apply for the institutional NRSA. Research Career Development: Applications may be submitted on behalf of candidates by domestic, nonfederal organizations, public or private institutions of higher education.
What the money can and cannot pay for
The Division of Comparative Medicine (DCM) helps meet the needs of biomedical researchers for high-quality, disease-free animals and specialized animal research facilities as well as supports the development of the biomedical workforce, specifically scientists with a background in veterinary medicine. Additionally, DCM seeks to increase small business participation in federally supported research and development as well as the private-sector commercialization of technology developed with federal support. It does this through the federal government's Small Business Innovation Research (SBIR) and Small Business Technology Transfer (STTR) programs. The Division of Construction and Instruments: This Division supports programs to expand the Nation’s capacity for the conduct of biomedical research by offering grants for the acquisition of state-of the-art biomedical research instrumentation and integrated instrument systems, advanced biomedical laboratory equipment, and, when specially appropriated funds are available, grants for construction and modernization of biomedical and biobehavioral research facilities.
Matching requirements
This program has no statutory formula. Matching requirements are not applicable to this assistance listing. MOE requirements are not applicable to this assistance listing.
Award range and average, in the agency's words
Awards vary in range depending on the particular activity codes. Research Centers grants have much larger ranges - from hundreds of thousands to several million dollars. All costs are shown on a single year basis. Awards may be for up to five years.
Funding history and past recipients
From fiscal 2021 to 2025, Research Infrastructure Programs (93.351) awarded$1.4 billion across 1,102 grant awards, an average of $1.3 million per award.
Who usually wins
Colleges and universities received 80% of the money, nonprofits 15% and small businesses 2.9%.
| Recipient type | Awards | Amount | Share |
|---|---|---|---|
| Colleges and universities | 832 | $1.1 billion | 80% |
| Nonprofits | 189 | $211 million | 15% |
| Small businesses | 44 | $40.4 million | 2.9% |
| Other | 36 | $32.0 million | 2.3% |
| Tribal governments and organizations | 1 | $348,724 | less than 0.1% |
By state
42 states have a page for this program: those that received at least $1 million or 10 awards.
| State | Awards | Amount |
|---|---|---|
| California | 137 | $183 million |
| Texas | 75 | $127 million |
| Oregon | 28 | $111 million |
| Massachusetts | 90 | $90.4 million |
| Washington | 20 | $87.3 million |
| Georgia | 26 | $85.5 million |
| Louisiana | 17 | $76.5 million |
| Wisconsin | 27 | $72.0 million |
| New York | 86 | $60.5 million |
| Missouri | 36 | $51.9 million |
| North Carolina | 45 | $41.3 million |
| Pennsylvania | 56 | $36.4 million |
| Maine | 19 | $34.2 million |
| Puerto Rico | 3 | $29.1 million |
| Maryland | 36 | $27.1 million |
| Colorado | 36 | $24.5 million |
| Tennessee | 31 | $21.7 million |
| Minnesota | 27 | $20.1 million |
| Alabama | 19 | $20.1 million |
| Illinois | 33 | $19.6 million |
| Iowa | 17 | $17.4 million |
| Michigan | 24 | $16.8 million |
| Florida | 24 | $16.5 million |
| Connecticut | 19 | $15.9 million |
| Ohio | 24 | $12.8 million |
| New Jersey | 15 | $11.8 million |
| Arizona | 10 | $10.7 million |
| Indiana | 11 | $9.4 million |
| Kentucky | 15 | $8.8 million |
| Virginia | 10 | $6.5 million |
| Kansas | 6 | $5.1 million |
| Utah | 7 | $4.8 million |
| South Carolina | 9 | $4.4 million |
| District of Columbia | 8 | $3.5 million |
| Nevada | 4 | $3.3 million |
| Nebraska | 6 | $2.8 million |
| Rhode Island | 7 | $2.5 million |
| New Mexico | 5 | $2.1 million |
| Mississippi | 5 | $1.6 million |
| New Hampshire | 4 | $1.6 million |
| Delaware | 4 | $1.2 million |
| Oklahoma | 1 | $1.2 million |
| North Dakota | 2 | $955,889 |
| Hawaii | 3 | $914,746 |
| Montana | 3 | $836,560 |
| West Virginia | 2 | $608,989 |
| Alaska | 1 | $345,000 |
| Arkansas | 3 | $342,800 |
| South Dakota | 1 | $258,080 |
| Idaho | 3 | $185,502 |