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Grants / Department of Health and Human Services / National Institutes of Health

NIH, CDC and FDA Small Business Innovation Research Grant (Parent SBIR [R43/R44] Clinical Trial Optional)

Open Closes April 5, 2027 (156 days left) Opportunity PA-27-100

National Institutes of Health is offering grants to small businesses. Applications close on April 5, 2027.

From the official notice on Grants.gov, last changed June 1, 2026. Checked October 31, 2026.

Key dates

PostedMay 28, 2026
DeadlineApril 5, 2027
Archived by Grants.govJune 4, 2027

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Who can apply

This opportunity is open to small businesses.

Only United States small business concerns (SBCs), as defined by the Small Business Administration (SBA)(sbir.gov/apply) are eligible to submit applications for this opportunity. Refer to Section III. Eligibility Information in the NOFO for additional information on eligibility. Foreign Organizations/International Collaborations:Non-domestic (non-U.S.) Entities (Foreign Organizations) are not eligible to apply. Non-domestic (non-U.S.) components of U.S. Organizations are not eligible to apply. Unfunded international collaborations or unfunded foreign components, as defined in the NIH Grants Policy Statement, may be allowed.

More grants for small businesses.

Is this a realistic fit?

What the grant funds

The Small Business Innovation Research (SBIR) program helps United States small business concerns (SBCs) bring scientific innovations to the marketplace. The SBIR program supports feasibility studies to later research and development (R&D) needed to develop a commercial product.

Category: Health.

How to apply

  1. Read the full notice and attachments on Grants.gov. The notice is the official source for deadlines and requirements.
  2. Make sure your organization has an active SAM.gov registration and Unique Entity ID; registration can take several weeks.
  3. Register on Grants.gov and submit through Workspace before the deadline and time given in the notice. Our application guide walks through each step.

Questions go to National Institutes of Health, SEEDinfo@nih.gov, 301-402-2541.

Open the official notice

Questions people ask

Who can apply for NIH, CDC and FDA Small Business Innovation Research Grant (Parent SBIR [R43/R44] Clinical Trial Optional)?

National Institutes of Health accepts applications from small businesses. The notice adds further conditions, so read its eligibility section.

What is the deadline for NIH, CDC and FDA Small Business Innovation Research Grant (Parent SBIR [R43/R44] Clinical Trial Optional)?

Closes April 5, 2027 (156 days left). Confirm the date and time in the official notice on Grants.gov.

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