NIH U01 funding opportunities: Research Project Cooperative Agreement
31 NIH notices for U01 (Research Project Cooperative Agreement) are open and 16 forecast. Like an R01, but NIH staff are substantially involved in the work.
- Open notices31
- Forecast16
- Projects funded under them7,795
Open NIH U01 notices
- Single Source for the Continuation of the Caring for OutPatiEnts after Acute Kidney Injury (COPE-AKI) Scientific and Data Research Center (U01 Clinical Trial Required)
Open Closes November 9, 2026 (2 days left) - Single Source for the Continuation of the Epidemiology of Diabetes Interventions and Complications (EDIC) Study Research Center (Collaborative U01 Clinical Trial Not Allowed)
Open Closes November 9, 2026 (2 days left) - Amyotrophic Lateral Sclerosis (ALS) Intermediate Patient Population Expanded Access (U01 Clinical Trial Required)
Open Closes November 10, 2026 (3 days left) - Single Source for the Continuation of the Physiology of the Weight Reduced State (POWERS) Study (U01- Clinical Trials Required)
Open Closes November 17, 2026 (10 days left) - Neural Ensembles & Used Substances (NExUS) Collaboratory: Building a Multimodal Inventory of Cell Ensembles Encoding the Effects of Addictive Substances (U01 Clinical Trial Not Allowed)
Open - NIDA Animal Genomics Program (U01 Clinical Trial Not Allowed)
Open - The NIDDK Disorders of Gastrointestinal Interoception Consortium (DGIC) - Clinical Research Centers (U01 Clinical Trial Not Allowed)
Open - Opportunities for Collaborative Research at the NIH Clinical Center (U01 Clinical Trial Optional)
Open - Continuation of the Cardiovascular Repository for-Type 1 Diabetes (CARE-T1D) Consortium U01 (Open Competition)- Research (U01, Clinical Trial Not Allowed)
Open - BRAIN Initiative: Brain Behavior Quantification and Synchronization- Next Generation Sensor Technology Development (U01 Clinical Trial Optional)
Open - Change of Recipient Organization (Type 7 Parent Clinical Trial Optional)
Open - Bioengineering Partnerships with Industry (U01 Clinical Trial Optional)
Open - Integrating Biospecimen Science Approaches into Clinical Assay Development (U01 Clinical Trial Not Allowed)
Open - BRAIN Initiative Connectivity across Scales (BRAIN CONNECTS): Specialized Projects for Scalable Technologies (U01 Clinical Trial Not Allowed)
Open - Utilizing the PLCO Biospecimens Resource to Bridge Gaps in Cancer Etiology and Early Detection Research (U01 Clinical Trial Not Allowed)
Open - Translational Efforts to Advance Gene-based Therapies for Ultra-Rare Neurological and Neuromuscular Disorders (U01 - Clinical Trial Optional)
Open - First in Human and Early Stage Clinical Trials of Novel Investigational Drugs or Neuromodulatory Device-based Interventions for Psychiatric Disorders (U01 Clinical Trial Required)
Open - NIDCD Cooperative Agreement for Clinical Trials in Communication Disorders (U01 - Clinical Trial Required)
Open - Early-Stage Development of Informatics Technologies for Cancer Research and Management (U01 Clinical Trial Optional)
Open - National Cooperative Drug/Device Discovery/Development Groups (NCDDG) for the Treatment of Mental Disorders (U01 Clinical Trial Optional)
Open - Limited Competition: Renewal of Existing NINDS-Supported Clinical Trial Cooperative Agreement Awards (U01 - Clinical Trials Required)
Open - Alzheimer's Drug-Development Program (U01 Clinical Trial Optional)
Open - Development of Candidate Medical Countermeasures (MCMs) and Technologies Against Radiological/Nuclear or Chemical Threats (U01 Clinical Trial Not Allowed)
Open - Genomic and Biologic Therapies for ADRD (U01 Clinical Trial Optional)
Open - The Metastasis Research Network (MetNet): MetNet Research Projects (U01 Clinical Trial Not Allowed)
Open - Administrative Supplements to Existing NIH Grants and Cooperative Agreements (Parent Admin Supp Clinical Trial Optional)
Open - Research Opportunities in Cancer Epidemiology Cohort Studies (U01 Clinical Trial Not Allowed)
Open - NIAID Clinical Trial Implementation Cooperative Agreement (U01 Clinical Trial Required)
Open - NIDCR Prospective Observational or Biomarker Validation Study Cooperative Agreement (U01 Clinical Trial Not Allowed)
Open - Causal Hypotheses on the Oral-Systemic Health Impacts of Human Behaviors among People with Chronic Conditions (U01 Clinical Trial Not Allowed)
Open - Pancreatic Cancer Detection Consortium: Research Units (U01 Clinical Trial Optional)
Open
Forecast U01 notices
- Notice of Intent to Publish a Funding Opportunity Announcement for Single Source for Continuation of the Environmental Determinants of Diabetes in The Young Study (TEDDY) Data Coordinating Center (U01 Clinical Trial Not Allowed)
Forecast - Forecast to Publish a Funding Opportunity Announcement for Cancer Epidemiology Cohorts: Building the Next Generation of Research Cohorts (U01 Clinical Trial Not Allowed)
Forecast - Stroke Preclinical Assessment Network (SPAN) to Support Translational Studies for Acute Cerebroprotection – Network Sites and Coordinating Center (U01- CT Not Allowed)
Forecast - Forecast to Publish a Funding Opportunity Announcement for Integrative Neuroscience Initiative on Alcoholism (INIA) Consortia (U01 Clinical Trial Optional)
Forecast - Single Source: Chronic Kidney Diseases of UnceRtain Etiology (CKDu) in Agricultural Communities (CURE) Research Consortium- Renal and Environmental Science Core (U01-Clinical Trial Not Allowed)
Forecast - Forecast to Publish a Funding Opportunity Announcement for Limited Competition for the Continuation of the National Consortium on Alcohol and Neurodevelopment in Adolescence (NCANDA) Research Project Sites (U01 Clinical Trials Optional)
Forecast - Continuation of the Collaborative Islet Transplantation Registry (U01 Clinical Trial Not allowed)
Forecast - Expanding the Therapeutic Pipeline for Treating and Preventing Alzheimer's Disease and Related Dementias: Preclinical Validation and Drug Discovery for Novel Candidate Targets (U01 Clinical Trial Not Allowed)
Forecast - Canine Cancer Immunotherapy Network (K9CIN; U01 Clinical Trial Not Allowed)
Forecast - Opportunities for Collaborative Research with the NIH Intramural Research Program (U01 Clinical Trial Optional)
Forecast - Multimodal AI to Accelerate Precision Medicine for Type 1 Diabetes (U01- Clinical Trials Not Allowed)
Forecast - Leveraging NAMs to understand disease triggers, discover early biomarkers and develop new classes of therapeutic strategies for Type 1 Diabetes (U01 Clinical Trial Not Allowed)
Forecast - Single Source Competition for Continuation of Understanding and Targeting the Pathophysiology of Youth-Onset Type 2 Diabetes Clinical Centers (U01 Clinical Trial Not Allowed)
Forecast - Amyotrophic Lateral Sclerosis (ALS) Intermediate Patient Population Expanded Access (U01 Clinical Trial Required)
Forecast - Alzheimer's Drug-Development Program (U01 Clinical Trial Optional)
Forecast - ancient DNA for Modern Genomics (aDMG) Research Projects (U01 Clinical Trials Not Allowed)
Forecast
Institutes that fund U01 projects under these notices
| Institute or center | Projects |
|---|---|
| National Cancer Institute (NCI) | 1,266 |
| National Heart Lung and Blood Institute (NHLBI) | 771 |
| National Institute of Allergy and Infectious Diseases (NIAID) | 719 |
| National Institute on Aging (NIA) | 670 |
| National Institute of Neurological Disorders and Stroke (NINDS) | 642 |
| National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) | 637 |
| National Institute of General Medical Sciences (NIGMS) | 595 |
| National Institute on Drug Abuse (NIDA) | 361 |
| National Institute of Mental Health (NIMH) | 324 |
| Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD) | 318 |
Closed U01 notices
- RFA-DK-27-125: Limited Competition for the Continuation of the Caring for OutPatiEnts after Acute Kidney Injury (COPE-AKI) Clinical Centers (U01 Clinical Trial Required)
- RFA-HG-27-011: GREGoRi Data Coordination and Outreach Center (U01, Clinical Trials Not Allowed)
- RFA-HG-27-012: GREGoRi Technology Integration Center (U01, Clinical Trials Optional)
- RFA-HG-27-013: GREGoRi Innovation Projects (U01 Clinical Trial Optional)
- RFA-DE-27-001: Community Engagement Evaluation and Data Coordination (CEED) Hub to Advance Data and Practice Transformation for Optimizing Oral Health for All (U01, Clinical Trial Not Allowed)
- RFA-RM-27-011: Development and Testing of a Multi-use Frameworks Playbook for Precision Medicine with AI: Integrating Imaging with Multimodal Data (PRIMED-AI) (U01 Clinical Trial Not Allowed)
- RFA-DK-27-121: Optimal Treatment Strategies for use of Anti-Obesity Medications (AOMs) in Children and Adolescents Clinical Centers (U01 Clinical Trial Required)
- RFA-DC-25-003: Cooperative Agreement for In Vivo High-Resolution Imaging for Inner Ear Visualization (U01 Clinical Trial Required)
- RFA-DA-27-013: HEAL Initiative: Limited Competition for the HEALthy Brain and Child Development Study - Research Project Sites (Collaborative U01- Clinical Trial Not Allowed)
- RFA-DK-27-301: Kidney Precision Medicine Project Recruitment Sites (U01 Clinical Trial Not Allowed)
- RFA-DK-27-302: Kidney Precision Medicine Project Tissue Interrogation Sites (U01 Clinical Trial Not Allowed)
- RFA-DA-27-002: Limited Competition for the Adolescent Brain Cognitive Development -Extended (ABCD-E) Study-Research Project Sites (U01 Clinical Trial Not Allowed)
- RFA-HL-27-008: HeartShare 2.0: Refining Heart Failure Subtypes and Treatment Targets for Personalized Clinical Trials - Clinical Trial Center and Clinical Centers (U01 Clinical Trial Optional)
- RFA-HL-27-002: Single Source: Cardiothoracic Surgical Trials Network (CTSN) Data Coordinating Center (U01 Clinical Trial Required)
- PAR-25-055: Clinical Validation of a Candidate Biomarker for Neurological or Neuromuscular Disorders (U01 Clinical Trial Optional)
- PAR-25-050: Analytical Validation of a Candidate Biomarker for Neurological or Neuromuscular Disorders(U01 Clinical Trial Optional)
- RFA-NS-25-017: BRAIN Initiative: Optimization of Instrumentation and Device Technologies for Recording and Modulation in the Nervous System (U01 Clinical Trials Not Allowed)
- RFA-AI-27-019: Impact of Initial Influenza Exposure on Immunity in Infants (U01 Clinical Trial Not Allowed)
- RFA-DK-26-308: Limited Competition Renewal for the Continuation of the Liver Cirrhosis Network: Clinical Research Centers (U01 Clinical Trial Required)
- PAR-25-239: NIDCR Prospective Observational or Biomarker Validation Study Cooperative Agreement (U01 Clinical Trial Not Allowed)
- RFA-HG-26-008: Single Source: Outcomes of Electronic Medical Records and Genomics (eMERGE) Genomic Risk Assessment and Management Network - Coordinating Center (U01 Clinical Trial Required)
- PAR-25-209: Analytical and Clinical Validation of Biomarkers for Alzheimers Disease (AD) and AD-Related Dementias (ADRD) (U01 Clinical Trial Optional)
- RFA-CA-25-032: Cancer Intervention and Surveillance Modeling Network (CISNET) (U01 Clinical Trial Not Allowed)
- RFA-HG-25-012: Limited Competition: Outcomes of Electronic Medical Records and Genomics (eMERGE) Genomic Risk Assessment and Management Network - Clinical Sites (U01, Clinical Trial Required)
- PA-25-147: NIDDK High Risk Multi-Center Clinical Study Cooperative Agreement (U01 Clinical Trial Required)
- PAR-25-089: NIDDK High Risk Multi-Center Clinical Study Cooperative Agreement (U01 Clinical Trial Not Allowed)
- PAR-25-119: Mechanistic links between diet, lipid metabolism, and tumor growth and progression (U01 Clinical Trial Not Allowed)
- RFA-CA-25-006: Revision Applications for Incorporation of Novel NCI- Supported Technology to Accelerate Cancer Research (U01 Clinical Trial Optional)
- RFA-AG-26-001: Single Source: National Longitudinal Study of Adolescent to Adult (Add) Health Wave VII (U01 Clinical Trial Not Allowed)
- RFA-AI-25-018: Mucosal Immunology Studies Team (MIST) (U01 Clinical Trial Not Allowed)
- RFA-AR-25-013: Limited Competition: Regenerative Medicine Innovation Project (RMIP) Investigator-Initiated Studies (U01 Clinical Trial Not Allowed)
- PAR-25-328: Grand Opportunity in Medications Development for Substance-Use Disorders (U01 Clinical Trial Optional)
- PAR-25-130: The Metastasis Research Network (MetNet): MetNet Research Projects (U01 Clinical Trial Not Allowed)
- PAR-24-100: NIAID Clinical Trial Implementation Cooperative Agreement (U01 Clinical Trial Required)
- RFA-DA-24-040: BRAIN Initiative: Brain-Behavior Quantification and Synchronization Transformative and Integrative Models of Behavior at the Organismal Level (U01 Clinical Trial Optional)
- RFA-DA-24-041: BRAIN Initiative: Brain-Behavior Quantification and Synchronization Transformative and Integrative Models of Behavior at the Organismal Level (U01 Clinical Trials Not Allowed)
- PAR-24-240: Genetic Architecture of Mental Disorders in Ancestrally Varied Populations II (U01 Clinical Trial Not Allowed)
- PAR-22-149: NEI Cooperative Agreement for Early-Stage Clinical Trials with Greater than Minimal Risk (U01 Clinical Trial Required)
- RFA-HL-26-009: Limited Competition: Clinical Research Sites (CRS) for the MACS/WIHS Combined Cohort Study (MWCCS) (U01 Clinical Trial Not Allowed)
- RFA-HL-26-010: Limited Competition: Data Analysis and Sharing Center (DASC) for the MACS/WIHS Combined Cohort Study (MWCCS) (U01 Clinical Trials Not Allowed)
- RFA-HL-26-011: Leadership and Coordination Center (LACC) for the MACS/WIHS Combined Cohort Study (MWCCS) (U01 Clinical Trials Not Allowed)
- RFA-HL-26-007: Single Source: Bench to Bassinet Congenital Heart disease Advancing New understanding in GEnomics Cohort (B2B CHANGE Cohort) Data Coordinating Center (U01 Clinical Trial Not Allowed)
- RFA-AG-25-015: Coordination Center for the Alzheimers Disease Sequencing Project Consortium (U01 Clinical Trial Not Allowed)
- RFA-HG-25-007: Informatics Tools for the Pangenome (U01 Clinical Trial Not Allowed)
- PAR-25-275: Research Opportunities in Established Cancer Epidemiology Cohort Studies (U01 Clinical Trial Not Allowed)
- PAR-25-186: Cancer Epidemiology Cohorts: Building the Next Generation of Research Cohorts (U01 Clinical Trial Not Allowed)
- RFA-NR-25-003: Transformative Research to Address Health Disparities and Advance Health Equity (U01 Clinical Trial Optional)
- RFA-RM-24-009: Human Virome Program: Developing novel and innovative tools to interrogate and annotate the human virome (U01 Clinical Trial Not Allowed)
- PA-23-189: Research Supplements to Promote Diversity in Health-Related Research (Admin Supp Clinical Trial Not Allowed)
- PAR-25-224: Integrative Research to Understand the Impact of Sex Differences on the Molecular Determinants of AD Risk and Responsiveness to Treatment (U01 Clinical Trial Optional)
- RFA-AG-25-032: Consortium for Neuroscience AD/ADRD in Low- and Middle-Income Countries (U01 Clinical Trial Not Allowed)
- RFA-AI-24-067: Development of Alternative Human Models of Radiation-Induced Injuries (Extracorporeal Systems) (U01 Clinical Trial Not Allowed)
- RFA-NS-25-010: Safety and Efficacy of Amyloid-Beta Directed Antibody Therapy in Mild Cognitive Impairment and Dementia with Evidence of Lewy Body Dementia and Amyloid-Beta Pathology (U01 - Clinical Trial Required)
- RFA-NS-25-024: Amyotrophic Lateral Sclerosis (ALS) Intermediate Patient Population Expanded Access (U01 Clinical Trial Required)
- PAR-22-114: Administrative Supplements to Support Cancer Disparity Collaborative Research (Clinical Trial Optional)
- RFA-MH-25-100: BRAIN Initiative: Scaled reagent resources for brain cell type-specific access across vertebrate species (U01 Clinical Trial Not Allowed)
- PAR-22-143: National Cooperative Drug/Device Discovery/Development Groups (NCDDG) for the Treatment of Mental Disorders or Alcohol Use Disorder (U01 Clinical Trial Optional)
- PAR-24-103: NIDDK High Risk Multi-Center Clinical Study Cooperative Agreement (U01 Clinical Trial Required)
- PAR-23-162: NIDCR Prospective Observational or Biomarker Validation Study Cooperative Agreement (U01 Clinical Trial Not Allowed)
- PAR-24-050: NIDCD Cooperative Agreement for Clinical Trials in Communication Disorders (U01 - Clinical Trial Required)
- PAR-24-102: NIDDK High Risk Multi-Center Clinical Study Cooperative Agreement (U01 Clinical Trial Not Allowed)
- RFA-DC-24-005: Cooperative Agreement for In Vivo High-Resolution Imaging for Inner Ear Visualization (U01 Clinical Trial Required)
- PAR-22-202: Grand Opportunity in Medications Development for Substance-Use Disorders (U01 Clinical Trial Optional)
- PAR-23-037: Multisite Clinical Research: Leveraging Network Infrastructure to Advance Research for Women, Children, Pregnant and Lactating Individuals, and Persons with Disabilities (U01 Clinical Trial Optional)
- RFA-DK-25-022: Precision Medicine for Type 1 Diabetic Nephropathy (U01 Clinical Trial Not Allowed)
- PAR-23-082: Integrative Research to Understand the Impact of Sex Differences on the Molecular Determinants of AD Risk and Responsiveness to Treatment (U01 Clinical Trial Optional)
- RFA-HG-23-026: Informatics Tools for the Pangenome (U01 Clinical Trial Not Allowed)
- RFA-CA-24-006: Translational Research Toward Development of a Kaposi Sarcoma Herpesvirus (KSHV) Vaccine (U01 Clinical Trial Optional)
- PAR-24-223: Alzheimer's Drug-Development Program (U01 Clinical Trial Optional)
- RFA-HG-24-021: Population Genomic Screening in Primary Care Cooperative Agreement (U01 - Clinical Trial Required)
- RFA-HG-24-022: Population Genomic Screening in Primary Care Coordinating Center(U01 -Clinical Trials Optional)
- RFA-HG-24-023: Population Genomic Screening in Primary Care Sequencing Center (U01 - Clinical Trial Optional)
- RFA-DA-25-057: Combined Neuromodulation and Behavioral Treatment Algorithm Development for Stimulant Use Disorder (StUD) Enriched for Vulnerable Phenotype (U01 Clinical Trial Required)
- PAR-22-162: Research Opportunities in Established Cancer Epidemiology Cohort Studies (U01 Clinical Trial Not Allowed)
- RFA-NS-24-037: Optimization of Genome Editing Therapeutics for Alzheimer's Disease-Related Dementias (ADRD) (U01 - Clinical Trials Not Allowed)
- RFA-DK-25-017: Limited Competition for the Continuation of Type 1 Diabetes in Acute Pancreatitis Consortium - Clinical Centers (T1DAPC-CCs) (U01 Clinical Trial Optional)
- RFA-DK-25-018: Single Source for the Continuation of the Type 1 Diabetes in Acute Pancreatitis Consortium - Data Coordinating Center (T1DAPC-DCC) (U01 Clinical Trial Optional)
- PAR-23-258: Analytical and Clinical Validation of Biomarkers for Alzheimers Disease (AD) and AD-Related Dementias (ADRD)?(U01 Clinical Trial Optional)
- RFA-CA-24-017: Early-Stage Development of Informatics Technologies for Cancer Research and Management (U01 Clinical Trial Optional)
- PAR-22-161: Cancer Epidemiology Cohorts: Building the Next Generation of Research Cohorts (U01 Clinical Trial Not Allowed)
- RFA-DA-25-037: Translating Socioenvironmental Influences on Neurocognitive Development and Addiction Risk (TranSINDA) (U01 Clinical Trial Not Allowed)
- PAR-22-053: Clinical Trial Readiness for Functional Neurological Disorders (U01 Clinical Trial Optional)
- PAR-22-047: Alzheimer's Drug-Development Program (U01 Clinical Trial Optional)
- PAR-22-123: Bioengineering Partnerships with Industry (U01 Clinical Trial Optional)
- RFA-CA-24-029: RNA Modifications Driving Oncogenesis (RNAMoDO; U01 Clinical Trial Not Allowed)
- PAR-22-147: Research Projects in Physical Sciences-Oncology (U01 Clinical Trial Optional)
- PAR-23-051: Mechanistic links between diet, lipid metabolism, and tumor growth and progression (U01 Clinical Trial Not Allowed)
- PAR-22-234: The Metastasis Research Network (MetNet): MetNet Research Projects (U01 Clinical Trial Not Allowed)
- RFA-DK-25-012: Single Source for the Continuation of the Human Pancreas Analysis Program (HPAP) for Type 1 Diabetes (HPAP-T1D) (U01 Clinical Trial Not Allowed)
- RFA-MH-25-195: Individually Measured Phenotypes to Advance Computational Translation in Mental Health (IMPACT-MH) (U01 Clinical Trial Optional)
- RFA-DK-25-019: The Chronic Pancreatitis Clinical Research Consortium (CPCRC)- Clinical Centers (CPCRC-CCs) (U01 Clinical Trial Optional)
- RFA-DK-25-020: Single Source for Chronic Pancreatitis Clinical Research Consortium (CPCRC) Data Coordinating Center (CPCRC-DCC) (U01 Clinical Trial Optional)
- RFA-DK-25-004: Coordinating Center for Type 1 Diabetes TrialNet (U01 Clinical Trial Required)
- RFA-DK-25-005: Type 1 Diabetes TrialNet Clinical Network Hub (U01 Clinical Trial Not Allowed)
- PAR-21-133: First in Human and Early Stage Clinical Trials of Novel Investigational Drugs or Devices for Psychiatric Disorders (U01 Clinical Trial Required)
- PAR-21-330: Utilizing the PLCO Biospecimens Resource to Bridge Gaps in Cancer Etiology and Early Detection Research (U01 Clinical Trial Not Allowed)
- PAR-22-030: Translational Efforts to Advance Gene-based Therapies for Ultra-Rare Neurological and Neuromuscular Disorders (U01 - Clinical Trial Optional)
- RFA-AI-24-029: Mechanisms of Inducing HIV Immunity in Early Life (MIEL) (U01 Clinical Trial Not Allowed)
- PAR-24-095: Analytical Validation of a Candidate Biomarker for Neurological or Neuromuscular Disorders(U01 Clinical Trial Optional)
- PAR-22-362: NIA Renewal and Competing Revision Cooperative Agreements in Aging Research (U01 Clinical Trial Optional)
Questions people ask
What is an NIH U01?
U01 is NIH's activity code for the Research Project Cooperative Agreement. Like an R01, but NIH staff are substantially involved in the work. Each notice sets its own budget limit, project length and due dates.
How many NIH U01 funding opportunities are open?
31 notices are open on Grants.gov, and 16 more are forecast, as of the latest data.