PAR-25-130: The Metastasis Research Network (MetNet): MetNet Research Projects (U01 Clinical Trial Not Allowed)
Closed
This grant is closed. A newer notice from the same program is open now: The Metastasis Research Network (MetNet): MetNet Research Projects (U01 Clinical Trial Not Allowed) (PAR-26-134). Status: Due dates in the notice, expires November 22, 2028. It is in our archive of National Institutes of Health notices from 2024.
National Institutes of Health offered grants of up to $500,000 to nonprofits, colleges and universities, state and local governments, tribes, small businesses and businesses. It expected to make $500,000 in total. Applications closed on June 20, 2025.
From the official notice on Grants.gov, last changed October 25, 2024. Checked November 7, 2026.
- Award ceiling$500,000
- Total funding$500,000
- Cost sharingNot required
- Funding typeCooperative Agreement
About this NIH notice
- Activity codeU01
- Clinical trialsNot allowed
- Funded byNCI
- Median yearly award$647,065
- Typical project length5 years
- U01, Research Project Cooperative Agreement. Like an R01, but NIH staff are substantially involved in the work. Other open U01 notices.
Projects funded under PAR-25-130 were run by National Cancer Institute (NCI, 4 projects). Contact the program officer at the institute that fits your project before you apply; the notice lists them.
Application due dates, page limits and budget limits are set in the notice. Read PAR-25-130 in the NIH Guide.
Other notices with this title
| Notice | Posted | Deadline | Status |
|---|---|---|---|
| PAR-26-134 | February 4, 2026 | Due dates in the notice, expires November 22, 2028 | Open |
| PAR-22-234 | August 25, 2022 | Closed October 24, 2024 | Closed |
Key dates
| Posted | October 25, 2024 |
|---|---|
| Deadline | June 20, 2025 |
| Archived by Grants.gov | July 26, 2025 |
Who can apply
This opportunity was open to nonprofits, colleges and universities, state and local governments, tribes, small businesses and businesses.
All 15 applicant types the notice lists
- State governments
- County governments
- City or township governments
- Special district governments
- Independent school districts
- Public and State controlled institutions of higher education
- Native American tribal governments (Federally recognized)
- Public housing authorities/Indian housing authorities
- Native American tribal organizations (other than Federally recognized tribal governments)
- Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education
- Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education
- Private institutions of higher education
- For profit organizations other than small businesses
- Small businesses
- Others (see text field entitled "Additional Information on Eligibility" for clarification)
Other Eligible Applicants include the following: Alaska Native and Native Hawaiian Serving Institutions; Asian American Native American Pacific Islander Serving Institutions (AANAPISISs); Eligible Agencies of the Federal Government; Faith-based or Community-based Organizations; Hispanic-serving Institutions; Historically Black Colleges and Universities (HBCUs); Indian/Native American Tribal Governments (Other than Federally Recognized); Non-domestic (non-U.S.) Entities (Foreign Organizations); Regional Organizations; Tribally Controlled Colleges and Universities (TCCUs) ; U.S. Territory or Possession.
Is this a realistic fit?
- Projects NIH funded under this notice had a median yearly award of $647,065; it allows up to $500,000 per award.
- Most of the program's money (69% over five years) went to colleges and universities.
- No cost sharing or match is required.
What the grant funds
The MetNet is a collection of Research Centers that support using systems level approaches to understand the non-linear, dynamic and emergent processes in metastasis. Considering chronological progression and biological scales, the MetNet seeks to collectively derive a more comprehensive and cohesive picture of metastasis as a whole body, systems-level problem.
Funded under PAR-25-130 so far
NIH funded 4 projects under PAR-25-130 in fiscal 2026, at 4 institutions. The median yearly award was $647,065.
| Project | Institution | Fiscal year | Award |
|---|---|---|---|
| Modeling bone metastasis and tumor dormancy in prostate cancer | Columbia University Health Sciences | 2026 | $681,310 |
| The role of circadian gene regulation in pancreatic cancer progression and immune evasion | University of Rochester | 2026 | $626,555 |
| Mechanisms of regulation of metastasis by cancer extracellular vesicle-activated pathway | Case Western Reserve University | 2026 | $667,575 |
| Deciphering tumor-immune coevolution during metastatic progression | Stanford University | 2026 | $605,108 |
Who has won Cancer Biology Research grants before
From fiscal 2021 to 2025, Cancer Biology Research (93.396) awarded $4.3 billion across 3,142 grant awards, an average of $1.4 million per award.
| Recipient | State | Awards | Amount |
|---|---|---|---|
| The Trustees of Columbia University in the City of New York | New York | 70 | $151 million |
| The Univeristy of Texas M.D. Anderson Cancer Center | Texas | 109 | $144 million |
| Sloan-Kettering Institute for Cancer Research | New York | 66 | $136 million |
| Dana-Farber Cancer Institute, Inc. | Massachusetts | 47 | $107 million |
| The Regents of the University of California, San Francisco | California | 64 | $95.5 million |
Applying now
This notice no longer takes applications. Apply under the newer notice, PAR-26-134, which is open now.
The notice on Grants.gov keeps its full text and attachments, which is useful for planning a resubmission.
Questions people ask
Is PAR-25-130 still open?
No. It closed on June 20, 2025. A newer notice is open: PAR-26-134, due dates in the notice, expires November 22, 2028.
Who can apply for The Metastasis Research Network (MetNet): MetNet Research Projects (U01 Clinical Trial Not Allowed)?
National Institutes of Health accepted applications from nonprofits, colleges and universities, state and local governments, tribes, small businesses and businesses. The notice adds further conditions, so read its eligibility section.
What is the deadline for The Metastasis Research Network (MetNet): MetNet Research Projects (U01 Clinical Trial Not Allowed)?
Closed June 20, 2025. Applications are no longer accepted; the program's newer notices are on this page when there are any.
How much funding is available?
Awards of up to $500,000 each. About $500,000 in total.
Who has been funded under PAR-25-130?
NIH RePORTER lists 4 projects funded under PAR-25-130 in fiscal 2026, at 4 institutions. The most were at Columbia University Health Sciences, University of Rochester, Case Western Reserve University.
Who has won Cancer Biology Research grants before?
The largest recipients over five fiscal years were The Trustees of Columbia University in the City of New York, The Univeristy of Texas M.D. Anderson Cancer Center, Sloan-Kettering Institute for Cancer Research. The program made 3,142 awards worth $4.3 billion in that time.
Similar open grants
- Single Source for the Continuation of the Caring for OutPatiEnts after Acute Kidney Injury (COPE-AKI) Scientific and Data Research Center (U01 Clinical Trial Required)
- Single Source for the Continuation of the Epidemiology of Diabetes Interventions and Complications (EDIC) Study Research Center (Collaborative U01 Clinical Trial Not Allowed)
- Amyotrophic Lateral Sclerosis (ALS) Intermediate Patient Population Expanded Access (U01 Clinical Trial Required)
- Single Source for the Continuation of the Physiology of the Weight Reduced State (POWERS) Study (U01- Clinical Trials Required)
- Canine Cancer Immunotherapy Network (K9CIN; U01 Clinical Trial Not Allowed)
- Opportunities for Collaborative Research with the NIH Intramural Research Program (U01 Clinical Trial Optional)