Well Told Grants

Grants / Department of Health and Human Services / National Institutes of Health

RFA-TR-23-010: Emergency Awards: HEAL Initiative-Early-Stage Discovery of New Pain and Opioid Use Disorder Targets Within the Understudied Druggable Proteome (R21 Clinical Trial Not Allowed)

Closed Closed May 22, 2023 Opportunity RFA-TR-23-010

This grant is closed. Who won this program's grants before is below, and similar open grants are at the end of the page. It is in our archive of National Institutes of Health notices from 2023.

National Institutes of Health offered grants to nonprofits, colleges and universities, state and local governments, tribes, small businesses and businesses. Applications closed on May 22, 2023.

From the official notice on Grants.gov, last changed April 14, 2023. Checked November 7, 2026.

About this NIH notice

Projects funded under RFA-TR-23-010 were run by National Institute of Neurological Disorders and Stroke (NINDS, 3 projects), National Institute of Dental and Craniofacial Research (NIDCR, 2 projects), National Institute on Drug Abuse (NIDA, 1 project) and National Institute on Aging (NIA, 1 project). Contact the program officer at the institute that fits your project before you apply; the notice lists them.

Application due dates, page limits and budget limits are set in the notice. Read RFA-TR-23-010 in the NIH Guide.

Other notices with this title

National Institutes of Health has posted this title under other numbers: earlier or later rounds, or the same competition for another area. Each has its own dates and may change its rules.

NoticePostedDeadlineStatus
RFA-TR-22-011January 20, 2022Closed April 17, 2023Closed

Key dates

PostedApril 14, 2023
DeadlineMay 22, 2023
Archived by Grants.govJune 27, 2023

Who can apply

This opportunity was open to nonprofits, colleges and universities, state and local governments, tribes, small businesses and businesses.

All 15 applicant types the notice lists

Other Eligible Applicants include the following: Alaska Native and Native Hawaiian Serving Institutions; Asian American Native American Pacific Islander Serving Institutions (AANAPISISs); Eligible Agencies of the Federal Government; Faith-based or Community-based Organizations; Hispanic-serving Institutions; Historically Black Colleges and Universities (HBCUs); Indian/Native American Tribal Governments (Other than Federally Recognized); Non-domestic (non-U.S.) Entities (Foreign Organizations); Regional Organizations; Tribally Controlled Colleges and Universities (TCCUs) ; U.S. Territory or Possession; Non-domestic (non-U.S.) Entities (Foreign Institutions) are not eligible to apply. Non-domestic (non-U.S.) components of U.S. Organizations are not eligible to apply. Foreign components, as defined in the NIH Grants Policy Statement, are not allowed.

More grants for nonprofits, colleges and universities, state and local governments, tribes, small businesses, businesses.

Is this a realistic fit?

What the grant funds

NCATS is issuing this FOA in response to the declared public health emergency issued by the Secretary, HHS. Please see Determination that a Public Health Emergency Exists Nationwide as the Result of the Opioid Crisis as renewed in Renewal of the Determination that a Public Health Emergency Exists Nationwide as the Result of the Continued Consequences of the Opioid Crisis. The purpose of this funding opportunity announcement (FOA) is to support early-stage research projects focusing on the identification of new druggable targets for pain, opioid use disorder and/or overdose within the understudied druggable proteome. This FOA is part of the NIH Helping to End Addiction Long Term (HEAL) initiative to accelerate the development of novel medications to treat all aspects of the opioid addiction cycle, including progression to chronic use, withdrawal symptoms, craving, relapse, and overdose.

Category: Education, Health, Income Security and Social Services.

Funded under RFA-TR-23-010 so far

NIH funded 7 projects under RFA-TR-23-010 in fiscal 2024, at 6 institutions. The median yearly award was $419,375.

Most projects: University of Florida (Florida), 2, University of California Berkeley (California), 1, Florida International University (Florida), 1, Duke University (North Carolina), 1, Stanford University (California), 1.

Recently funded projects
ProjectInstitutionFiscal yearAward
Targeting GTP Cyclohydrolase 1 for treating chronic orofacial pain R21University of Florida2024$27,063
Role of Scn1b in Susceptibility to Neuropathic Pain R21University of California Berkeley2024$415,519
The potential benefits of autophagy activator TFEB in opioid use disorder in mice R21Florida International University2024$405,625
Exploring the unknown function of LRRC55 in pain R21Duke University2024$444,125
Binding NF-κB essential modulator (NEMO) to Treat Surgical Pain R21Stanford University2024$427,187
The involvement of GPR37L1 on a chronic migraine-like state R21Florida Atlantic University2024$419,375
Role of Understudied aGPCRs in Orofacial Neuropathic Pain R21University of Florida2024$419,375

From NIH RePORTER, which lists each project once per fiscal year it was funded. Amounts are the yearly award.

Who has won Aging Research grants before

From fiscal 2021 to 2025, Aging Research (93.866) awarded $19 billion across 11,026 grant awards, an average of $1.7 million per award.

Largest recipients, fiscal 2021 to 2025
RecipientStateAwardsAmount
The Regents of the University of California, San FranciscoCalifornia337$575 million
The Trustees of Columbia University in the City of New YorkNew York242$574 million
University of Southern CaliforniaCalifornia203$572 million
The Washington UniversityMissouri210$556 million
Regents of the University of MichiganMichigan232$538 million

Top states: California ($3.4 billion), New York ($2.0 billion), Massachusetts ($1.8 billion), Pennsylvania ($1.0 billion), Texas ($912 million).

Who has won Extramural Research Programs in the Neurosciences and Neurological Disorders grants before

From fiscal 2021 to 2025, Extramural Research Programs in the Neurosciences and Neurological Disorders (93.853) awarded $9.1 billion across 8,641 grant awards, an average of $1.0 million per award.

Largest recipients, fiscal 2021 to 2025
RecipientStateAwardsAmount
The General Hospital CorporationMassachusetts203$288 million
The Regents of the University of California, San FranciscoCalifornia248$277 million
The Johns Hopkins UniversityMaryland230$276 million
The Trustees of Columbia University in the City of New YorkNew York188$226 million
Regents of the University of MichiganMichigan179$221 million

Top states: California ($1.4 billion), New York ($926 million), Massachusetts ($906 million), Pennsylvania ($626 million), Texas ($499 million).

Who has won Drug Use and Addiction Research Programs grants before

From fiscal 2021 to 2025, Drug Use and Addiction Research Programs (93.279) awarded $7.3 billion across 5,071 grant awards, an average of $1.4 million per award.

Largest recipients, fiscal 2021 to 2025
RecipientStateAwardsAmount
Yale UnivConnecticut150$305 million
The Johns Hopkins UniversityMaryland156$262 million
University of California, San DiegoCalifornia120$242 million
University of Pittsburgh - of the Commonwealth System of Higher EducationPennsylvania100$182 million
New York UniversityNew York62$173 million

Top states: California ($1.1 billion), New York ($773 million), Massachusetts ($613 million), Pennsylvania ($488 million), Maryland ($434 million).

Other programs behind this notice

Applying now

This notice no longer takes applications. Agencies often post the same opportunity again under a new number, so check the program's notices on Grants.gov and the similar open grants below.

The notice on Grants.gov keeps its full text and attachments, which is useful for planning a resubmission.

Questions people ask

Is RFA-TR-23-010 still open?

No. It closed on May 22, 2023.

Who can apply for Emergency Awards: HEAL Initiative-Early-Stage Discovery of New Pain and Opioid Use Disorder Targets Within the Understudied Druggable Proteome (R21 Clinical Trial Not Allowed)?

National Institutes of Health accepted applications from nonprofits, colleges and universities, state and local governments, tribes, small businesses and businesses. The notice adds further conditions, so read its eligibility section.

What is the deadline for Emergency Awards: HEAL Initiative-Early-Stage Discovery of New Pain and Opioid Use Disorder Targets Within the Understudied Druggable Proteome (R21 Clinical Trial Not Allowed)?

Closed May 22, 2023. Applications are no longer accepted; the program's newer notices are on this page when there are any.

Who has been funded under RFA-TR-23-010?

NIH RePORTER lists 7 projects funded under RFA-TR-23-010 in fiscal 2024, at 6 institutions. The most were at University of Florida, University of California Berkeley, Florida International University.

Who has won Oral Diseases and Disorders Research grants before?

The largest recipients over five fiscal years were Regents of the University of Michigan, The Regents of the University of California, San Francisco, University of Southern California. The program made 2,263 awards worth $1.9 billion in that time.

Similar open grants