Research and Training in Complementary and Integrative Health (93.213)
Research and Training in Complementary and Integrative Health (Assistance Listing 93.213) is run by the National Institutes of Health, part of the Department of Health and Human Services. It awarded $575 million in 653 grants from fiscal 2021 to 2025, about $880,790 per award on average. 72 funding opportunities are open or forecast now.
The typical award was $508,660. Half of the 653 awards fell between $248,686 and $1.2 million, and they ranged from $0 to $8.6 million.
- Awarded, FY 2021 to 2025$575 million
- Grant awards653
- Typical award$508,660
- Awarded in FY 2025$115 million
- Size rank343 of 1,823
- Type of assistanceProject grants, training
Key findings
- Annual funding rose from $110 million in fiscal 2021 to $115 million in fiscal 2025.
- It is the 343rd largest of 1,823 federal grant programs by five-year awards.
- The 20 largest recipients received 44% of the money.
- Awards went to recipients in 42 states and territories.
What the program funds
NCCIH is the lead Federal agency for scientific research on the fundamental science, usefulness, and safety of complementary and integrative treatments and practices. NCCIH seeks to build knowledge across disciplines, focusing on the whole person, and taking a transdisciplinary approach that integrates the natural, social, and health sciences and transcends traditional boundaries. To address the need for objective evidence on the fundamental science, safety and efficacy of complementary and integrative health approaches, NCCIH supports rigorous scientific investigation to better understand how these interventions impact health, for whom, and the optimal methods of practice and delivery. By deepening our scientific understanding of the connections that exist across domains of human health, we can better understand how conditions interrelate, define multicomponent interventions that address these problems, and expand how we support patients through the full continuum of their health experience, including the return to health. To evaluate complementary and integrative health approaches. The following objectives support this goal: (1) coordinate and facilitate the investigation of complementary and integrative health approaches through peer-reviewed grant solicitations; (2) interface with the NCCIH National Advisory Council; (3) conduct technology assessment conferences for the purpose of establishing areas of Clinical and Pre-clinical research that need to be further developed within complementary health approaches; and (4) maintain a comprehensive bibliographic data base in conjunction with the National Library of Medicine. The National Center for Complementary and Integrative Health (NCCIH) regularly examines and redefines its research priorities. In setting research priorities, NCCIH considers its existing research portfolio, its 5-year strategic plan, the recommendations of the National Advisory Council for Complementary and Integrative Health, current scientific advances, the plans of other NIH institutes and centers, and input from expert panels and stakeholders. Research constituting a rigorous evidence base for complementary health approaches will be developed through a range of research strategies including basic and translational research, and clinical investigation. Priority setting also takes into account: 1)scientific promise, 2)amenability to rigorous scientific inquiry,3) potential to change health practices, and 4) relationship to use and practice. Research Approaches Basic, translational, efficacy/effectiveness, and implementation research for Complementary and Integrative Health approaches need to be studied across the research continuum. NCCIH continues to emphasize basic research that defines biological effects and mechanisms of action; this research is aimed at understanding the nature of complementary health approaches such as their biology, physiology, and physical, chemical and behavioral properties. NCCIH also supports the development of tools, models, and methodologies for studying these approaches. NCCIH continues to encourage efficacy studies to determine specific clinical effects of complementary health approaches under carefully controlled conditions that minimize nonspecific and contextual effects. There is also the need to strengthen translational and preliminary clinical research required to design and implement definitive clinical research and "real world" outcomes and effectiveness research that capitalizes on the reality that many complementary health approaches are in widespread public use. NCCIH’s support of translational research addresses the need for valid, reliable and relevant research tools, outcome measures, and innovative methodology to enhance the rigor of complementary health approaches within clinical studies and to ensure that they are maximally informative. NCCIH emphasizes studies that inform the design of future trials such as those that will: develop and validate outcome measures; standardize treatment protocols or algorithms; validate treatment algorithms and/or; develop measures of quality control or treatment fidelity; assess effects of various doses or intervention durations; develop preliminary clinical evidence regarding efficacy and safety to support estimates of sample size; or establish feasibility of interventions or study designs in specific populations for future studies.
Open and forecast opportunities
- NCCIH Natural Product Early Phase Clinical Trial Phased Innovation Award (R61/R33 Clinical Trial Required)
- NCCIH Natural Product Early Phase Clinical Trial Award (R33 Clinical Trial Required)
- NCCIH Natural Product Mid Phase Clinical Trial (R01 Clinical Trial Required)
- NCCIH Multi-Site Feasibility Clinical Trials of Mind and Body Interventions (R01 Clinical Trial Required)
- Investigator Initiated Clinical Trials of Complementary and Integrative Interventions Delivered Remotely or via mHealth (R01 Clinical Trial Required)
- Feasibility Clinical Trials of Mind and Body Interventions for NCCIH High Priority Research Topics (R34 Clinical Trial Required)
- HEAL Initiative: Pain Research Enhancement Program (PREP) (R15 Clinical Trial Optional)
- Competing Revisions to Existing NIH Single Project Research Grants and Cooperative Agreements (Clinical Trial Optional)
- NIH Research Software Engineer (RSE) Award (R50 Clinical Trials Not Allowed)
- Intervention Research to Improve Native American Health (R34 Clinical Trial Optional)
- HEAL Initiative: Studies to Enable Analgesic Discovery (R61/R33 - Clinical Trial Not Allowed)
- HEAL Initiative: Integrative Management of Chronic Pain and OUD for Whole Recovery (IMPOWR): Research Centers (RM1 Clinical Trial Required)
- HEAL Initiative: Integrative Management of chronic Pain and OUD for Whole Recovery (IMPOWR) - Building Engagement, Assistance, Capacity, Outreach, and Networks (BEACON) Center (U2C Clinical Trial Not Allowed)
- Biomedical Research Environment and Sponsored Programs Administration Development (BRE-SPAD) Program (UC2- Clinical Trial Not Allowed)
- BRAIN Initiative: Preclinical Proof of Concept for Novel Recording and Modulation Technologies in the Human CNS (R18 - Clinical Trial Not Allowed)
- BRAIN Initiative: Development and Validation of Novel Tools to Probe Cell-Specific and Circuit-Specific Processes in the Brain (R01 Clinical Trial Not Allowed)
- BRAIN Initiative: Exploratory Research Opportunities Using Invasive Neural Recording and Stimulating Technologies in the Human Brain (R61 Clinical Trial Not Allowed)
- NIH, CDC and FDA Small Business Innovation Research Grant (Parent SBIR [R43/R44] Clinical Trial Optional)
- NIH Small Business Technology Transfer Grant (Parent STTR [R41/R42] Clinical Trial Optional)
- Short Courses on Innovative Methodologies and Approaches in the Behavioral and Social Sciences (R25 Clinical Trials Not Allowed)
- Mentored Patient-Oriented Research Career Development Award (Parent K23 Independent Clinical Trial Not Allowed)
- Mentored Research Scientist Development Award (Parent K01 - Independent Clinical Trial Required)
- Mentored Research Scientist Development Award (Parent K01 - Independent Clinical Trial Not Allowed)
- NIH Pathway to Independence Award (Parent K99/R00 Independent Clinical Trial Not Allowed)
- NIH Pathway to Independence Award (Parent K99/R00 Independent Clinical Trial Required)
Rules from the program listing
Who can apply
Universities, colleges, hospitals, laboratories, and other public or private nonprofit domestic institutions, including State and local units of government, and individuals are eligible to make application for grant support of research by a named principal investigator or a research career development candidate. For-profit organizations are also eligible, with the exception of NRSA. Individual NRSA awardees must be nominated and sponsored by a public or nonprofit private institution having staff and facilities appropriate to the proposed research training program. All NRSA awardees must be citizens or have been admitted to the United States for permanent residence. To be eligible, predoctoral candidates must have completed the baccalaureate degree, and postdoctoral awardees must have a professional or scientific degree (e.g., M.D., Ph.D., D.D.S., D.O., N.D., D.C., D.V.M., Sc.D., D.Eng., or equivalent domestic or foreign degree). SBIR grants can be awarded only to domestic small businesses (entities that are independently owned and operated for profit, are not dominant in the field in which research is being proposed and have no more than 500 employees). Primary employment (more than one-half time) of the principal investigator must be with the small business at the time of award and during the conduct of the proposed project. In both Phase I and Phase II, the research must be performed in the U.S. or its possessions.
What the money can and cannot pay for
Research Grants provide funds for salaries, equipment, supplies, travel, and other expenses associated with scientific investigation relevant to program objectives. Individual National Research Service Awards (NRSAs) are made to individuals for research training in specified biomedical shortage areas. In addition, grants may be made to institutions to enable them to make NRSAs to individuals selected by them. Each individual who receives a NRSA is obligated upon termination of the award to comply with certain service and payback provisions. Small Business Innovation Research (SBIR) Phase I grants (of approximately 6-months' duration) are to establish the technical merit and feasibility of a proposed research effort that may lead to a commercial product or process. Phase II grants are for the continuation of the research initiated in Phase I that are likely to result in commercial products or processes. Only Phase I awardees are eligible to receive Phase II support. Small Business Technology Transfer (STTR) Phase I grants (normally of 1-year duration) are to determine the scientific, technical, and commercial merit and feasibility of the proposed cooperative effort that has potential for commercial application. Phase II funding is based on results of research initiated in Phase I and scientific and technical merit and commercial potential on Phase II application.
Matching requirements
This program has no statutory formula. Matching requirements are not applicable to this assistance listing. MOE requirements are not applicable to this assistance listing.
Award range and average, in the agency's words
For Fiscal Years 2022 - 2023 (as of 7/20/2023), the total costs (which is the sum of the direct costs plus the facilities & administration costs) for competing grants ranged from a low of $28,500 to a high of $2,439,270. For this same time period, the average, total costs for competing grants varied based on "budget mechanism", as follows: Research Projects: $428,092 Cooperative Agreements: $1,115,156 Conference Grants: $36,180 Individual Fellowships: $45,712 Career Development: $35,992 Institutional Training: $419,354 Small Business (SBIR/STTR): $393,304
Funding history and past recipients
From fiscal 2021 to 2025, Research and Training in Complementary and Integrative Health (93.213) awarded $575 million across 653 grant awards, an average of $880,790 per award.
Who usually wins
Colleges and universities received 71% of the money, nonprofits 23% and small businesses 3.8%.
| Recipient type | Awards | Amount | Share |
|---|---|---|---|
| Colleges and universities | 466 | $406 million | 71% |
| Nonprofits | 130 | $135 million | 23% |
| Small businesses | 40 | $21.6 million | 3.8% |
| Other | 16 | $12.9 million | 2.2% |
| State and local governments | 1 | $54,197 | less than 0.1% |
By state
35 states have a page for this program: those that received at least $1 million or 10 awards.
| State | Awards | Amount |
|---|---|---|
| California | 96 | $100 million |
| Massachusetts | 81 | $86.8 million |
| New York | 40 | $33.7 million |
| North Carolina | 28 | $30.9 million |
| Connecticut | 22 | $29.9 million |
| Washington | 24 | $29.5 million |
| Pennsylvania | 24 | $19.7 million |
| Illinois | 24 | $19.5 million |
| Oregon | 22 | $17.9 million |
| Rhode Island | 21 | $16.7 million |
| Michigan | 21 | $16.6 million |
| Minnesota | 15 | $16.0 million |
| Ohio | 13 | $15.5 million |
| Maryland | 14 | $13.2 million |
| Utah | 14 | $12.7 million |
| Georgia | 15 | $12.2 million |
| Texas | 25 | $11.5 million |
| Alabama | 12 | $9.3 million |
| Arizona | 8 | $9.0 million |
| Missouri | 14 | $8.3 million |
| Colorado | 19 | $7.8 million |
| Wisconsin | 7 | $7.5 million |
| Florida | 15 | $7.0 million |
| Virginia | 14 | $5.3 million |
| Indiana | 7 | $5.2 million |
| Tennessee | 6 | $4.4 million |
| Iowa | 2 | $4.0 million |
| Kentucky | 7 | $3.7 million |
| Oklahoma | 3 | $3.4 million |
| Louisiana | 4 | $3.3 million |
| Hawaii | 1 | $3.2 million |
| South Carolina | 10 | $2.5 million |
| Mississippi | 3 | $2.2 million |
| New Jersey | 8 | $2.2 million |
| District of Columbia | 4 | $2.1 million |
| Montana | 1 | $600,000 |
| West Virginia | 1 | $410,173 |
| Delaware | 4 | $386,440 |
| Vermont | 1 | $305,445 |
| Nebraska | 1 | $265,893 |
| Arkansas | 1 | $263,296 |
| New Hampshire | 1 | $1,245 |