Well Told Grants

Grants / Department of Health and Human Services / National Institutes of Health

RFA-TR-22-011: Emergency Awards: HEAL Initiative-Early-Stage Discovery of New Pain and Opioid Use Disorder Targets Within the Understudied Druggable Proteome (R21 Clinical Trial Not Allowed)

Closed Closed April 17, 2023 Opportunity RFA-TR-22-011

This grant is closed. Who won this program's grants before is below, and similar open grants are at the end of the page. It is in our archive of National Institutes of Health notices from 2022.

National Institutes of Health offered grants of up to $275,000 to nonprofits, colleges and universities, state and local governments, tribes, small businesses and businesses. Applications closed on April 17, 2023.

From the official notice on Grants.gov, last changed April 17, 2023. Checked November 7, 2026.

About this NIH notice

Projects funded under RFA-TR-22-011 were run by National Institute of Neurological Disorders and Stroke (NINDS, 4 projects), National Center for Advancing Translational Sciences (NCATS, 2 projects), National Institute on Drug Abuse (NIDA, 1 project) and National Center for Complementary and Integrative Health (NCCIH, 1 project). Contact the program officer at the institute that fits your project before you apply; the notice lists them.

Application due dates, page limits and budget limits are set in the notice. Read RFA-TR-22-011 in the NIH Guide.

Other notices with this title

National Institutes of Health has posted this title under other numbers: earlier or later rounds, or the same competition for another area. Each has its own dates and may change its rules.

NoticePostedDeadlineStatus
RFA-TR-23-010April 14, 2023Closed May 22, 2023Closed

Key dates

PostedJanuary 20, 2022
DeadlineApril 17, 2023
Archived by Grants.govMay 17, 2023

Who can apply

This opportunity was open to nonprofits, colleges and universities, state and local governments, tribes, small businesses and businesses.

All 15 applicant types the notice lists

Other Eligible Applicants include the following: Alaska Native and Native Hawaiian Serving Institutions; Asian American Native American Pacific Islander Serving Institutions (AANAPISISs); Eligible Agencies of the Federal Government; Faith-based or Community-based Organizations; Hispanic-serving Institutions; Historically Black Colleges and Universities (HBCUs); Indian/Native American Tribal Governments (Other than Federally Recognized); Non-domestic (non-U.S.) Entities (Foreign Organizations); Regional Organizations; Tribally Controlled Colleges and Universities (TCCUs) ; U.S. Territory or Possession; Non-domestic (non-U.S.) Entities (Foreign Institutions) are not eligible to apply. Non-domestic (non-U.S.) components of U.S. Organizations are not eligible to apply. Foreign components, as defined in the NIH Grants Policy Statement, are not allowed.

More grants for nonprofits, colleges and universities, state and local governments, tribes, small businesses, businesses.

Is this a realistic fit?

What the grant funds

NCATS is issuing this FOA in response to the declared public health emergency issued by the Secretary, HHS. Please see Determination that a Public Health Emergency Exists Nationwide as the Result of the Opioid Crisis as renewed in Renewal of the Determination that a Public Health Emergency Exists Nationwide as the Result of the Continued Consequences of the Opioid Crisis. The purpose of this funding opportunity announcement (FOA) is to support early-stage research projects focusing on the identification of new druggable targets for pain, opioid use disorder and/or overdose within the understudied druggable proteome. This FOA is part of the NIH Helping to End Addiction Long Term (HEAL) initiative to accelerate the development of novel medications to treat all aspects of the opioid addiction cycle, including progression to chronic use, withdrawal symptoms, craving, relapse, and overdose.

Category: Education, Health.

Funded under RFA-TR-22-011 so far

NIH funded 8 projects under RFA-TR-22-011 in fiscal 2022 to 2023, at 8 institutions. The median yearly award was $432,062.

Recently funded projects
ProjectInstitutionFiscal yearAward
Exploration of MBD1 as a therapeutic target for chronic pain R21University of Minnesota2023$419,129
DISCOVERY OF NOVEL TARGETS FOR POST-TRAUMATIC HEADACHE R21Washington University2023$428,250
Structure-Function and Signaling of Glutamate Delta 1 in Pain Mechanism R21Creighton University2023$44,586
G alpha Z subunit as a potential therapeutic target to modulate mu opioid receptor pharmacology R21University of Rochester2022$423,500
Discovery of novel openers of the understudied human drug target Kir6.1 R21New York University School of Medicine2022$466,125
Novel genetically-encoded inhibitors to probe functional logic of Cav-beta molecular diversity R21Columbia University Health Sciences2022$449,834
Erythrocyte Autophagy Proteins as Potential Non-opioid Novel Targets for Pain in Sickle Cell Disease R21University of Illinois at Chicago2022$455,195
The role of a lysosomal mechano-sensitive ion channel in pain R21Indiana University Indianapolis2022$435,875

From NIH RePORTER, which lists each project once per fiscal year it was funded. Amounts are the yearly award.

Who has won Aging Research grants before

From fiscal 2021 to 2025, Aging Research (93.866) awarded $19 billion across 11,026 grant awards, an average of $1.7 million per award.

Largest recipients, fiscal 2021 to 2025
RecipientStateAwardsAmount
The Regents of the University of California, San FranciscoCalifornia337$575 million
The Trustees of Columbia University in the City of New YorkNew York242$574 million
University of Southern CaliforniaCalifornia203$572 million
The Washington UniversityMissouri210$556 million
Regents of the University of MichiganMichigan232$538 million

Top states: California ($3.4 billion), New York ($2.0 billion), Massachusetts ($1.8 billion), Pennsylvania ($1.0 billion), Texas ($912 million).

Who has won Extramural Research Programs in the Neurosciences and Neurological Disorders grants before

From fiscal 2021 to 2025, Extramural Research Programs in the Neurosciences and Neurological Disorders (93.853) awarded $9.1 billion across 8,641 grant awards, an average of $1.0 million per award.

Largest recipients, fiscal 2021 to 2025
RecipientStateAwardsAmount
The General Hospital CorporationMassachusetts203$288 million
The Regents of the University of California, San FranciscoCalifornia248$277 million
The Johns Hopkins UniversityMaryland230$276 million
The Trustees of Columbia University in the City of New YorkNew York188$226 million
Regents of the University of MichiganMichigan179$221 million

Top states: California ($1.4 billion), New York ($926 million), Massachusetts ($906 million), Pennsylvania ($626 million), Texas ($499 million).

Who has won Drug Use and Addiction Research Programs grants before

From fiscal 2021 to 2025, Drug Use and Addiction Research Programs (93.279) awarded $7.3 billion across 5,071 grant awards, an average of $1.4 million per award.

Largest recipients, fiscal 2021 to 2025
RecipientStateAwardsAmount
Yale UnivConnecticut150$305 million
The Johns Hopkins UniversityMaryland156$262 million
University of California, San DiegoCalifornia120$242 million
University of Pittsburgh - of the Commonwealth System of Higher EducationPennsylvania100$182 million
New York UniversityNew York62$173 million

Top states: California ($1.1 billion), New York ($773 million), Massachusetts ($613 million), Pennsylvania ($488 million), Maryland ($434 million).

Other programs behind this notice

Applying now

This notice no longer takes applications. Agencies often post the same opportunity again under a new number, so check the program's notices on Grants.gov and the similar open grants below.

The notice on Grants.gov keeps its full text and attachments, which is useful for planning a resubmission.

Questions people ask

Is RFA-TR-22-011 still open?

No. It closed on April 17, 2023.

Who can apply for Emergency Awards: HEAL Initiative-Early-Stage Discovery of New Pain and Opioid Use Disorder Targets Within the Understudied Druggable Proteome (R21 Clinical Trial Not Allowed)?

National Institutes of Health accepted applications from nonprofits, colleges and universities, state and local governments, tribes, small businesses and businesses. The notice adds further conditions, so read its eligibility section.

What is the deadline for Emergency Awards: HEAL Initiative-Early-Stage Discovery of New Pain and Opioid Use Disorder Targets Within the Understudied Druggable Proteome (R21 Clinical Trial Not Allowed)?

Closed April 17, 2023. Applications are no longer accepted; the program's newer notices are on this page when there are any.

How much funding is available?

Awards of up to $275,000 each.

Who has been funded under RFA-TR-22-011?

NIH RePORTER lists 8 projects funded under RFA-TR-22-011 in fiscal 2022 to 2023, at 8 institutions. The most were at University of Minnesota, Washington University, Creighton University.

Who has won Oral Diseases and Disorders Research grants before?

The largest recipients over five fiscal years were Regents of the University of Michigan, The Regents of the University of California, San Francisco, University of Southern California. The program made 2,263 awards worth $1.9 billion in that time.

Similar open grants