Arthritis, Musculoskeletal and Skin Diseases Research (93.846)
Arthritis, Musculoskeletal and Skin Diseases Research (Assistance Listing 93.846) is run by the National Institutes of Health, part of the Department of Health and Human Services. It awarded $2.6 billion in 2,898 grants from fiscal 2021 to 2025, about $908,452 per award on average. 62 funding opportunities are open or forecast now.
The typical award was $520,761. Half of the 2,897 awards fell between $269,070 and $1.4 million, and they ranged from $0 to $10.5 million.
- Awarded, FY 2021 to 2025$2.6 billion
- Grant awards2,898
- Typical award$520,761
- Awarded in FY 2025$537 million
- Size rank136 of 1824
- Type of assistanceProject grants
Key findings
- Annual funding rose from $495 million in fiscal 2021 to $537 million in fiscal 2025.
- It is the 136th largest of 1,824 federal grant programs by five-year awards.
- The 20 largest recipients received 45% of the money.
- Awards went to recipients in 44 states and territories.
What the program funds
The National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS) mission is to support research into the causes, treatment, and prevention of arthritis and musculoskeletal and skin diseases; training of basic and clinical scientists to carry out this research; and dissemination of information on research progress in these diseases. The Extramural Program promotes and supports basic, translational, and clinical studies of Systemic Rheumatic and Autoimmune Diseases, Skin Biology and Diseases, Bone Biology and Diseases, Muscle Biology and Diseases, and Joint Biology and Diseases and Orthopaedics. NIAMS Systemic Rheumatic and Autoimmune Diseases programs address basic, translational, and clinical research, including clinical trials and observational and mechanistic studies, focused on immune-mediated arthritis and autoimmune-related acute and chronic disorders in adults and children. NIAMS Skin Biology and Diseases programs support basic, translational, and clinical research in skin, including both common and rare skin diseases. These programs include investigations of the basic molecular, cellular, and developmental biology of skin, as well as studies of skin as an immune, sensory, endocrine, and metabolic organ. NIAMS Bone Biology and Diseases programs support research on the control of bone formation, resorption, and mineralization as well as the effects of signaling molecules on bone cells. They support clinical studies of interventions to prevent fractures associated with osteoporosis and research into less common bone diseases. NIAMS Muscle Biology and Diseases programs encourage research on muscle developmental biology, growth, maintenance, and hypertrophy; physiology of contraction; structural biology of the contractile apparatus; disease mechanisms; biomarkers and outcome measures; and development and clinical testing of therapies for conditions including the muscular dystrophies. NIAMS Joint Biology, Diseases, and Orthopaedics programs support a broad spectrum of research centered on the interplay among the body’s muscles, bones, and connective tissues. They encourage tissue engineering and regenerative medicine research, molecular biology, imaging, and clinical research, and the treatment and prevention of orthopaedic conditions. NIAMS participates in the Small Business Innovation Research (SBIR) and Small Business Technology Transfer (STTR) programs. The SBIR program is intended to increase private sector commercialization of innovations derived from Federal research and development; to increase small business participation in Federal research and development; and to foster and encourage participation of socially and economically disadvantaged small business concerns and women-owned small business concerns in technological innovation. The STTR program is intended to stimulate and foster scientific and technological innovation through cooperative research and development carried out between small business concerns and research institutions; to foster technology transfer between small business concerns and research institutions; to increase private sector commercialization of innovations derived from Federal research and development; and to foster and encourage participation of socially and economically disadvantaged small business concerns and women-owned small business concerns in technological innovation.
Open opportunities
- Exploratory Clinical Trial Grants in Arthritis and Musculoskeletal and Skin Diseases (R61 Clinical Trial Required)
- Clinical Observational (CO) Studies in Musculoskeletal, Rheumatic, and Skin Diseases (R01 Clinical Trial Not Allowed)
- HEAL Initiative: Pain Research Enhancement Program (PREP) (R15 Clinical Trial Optional)
- NIH Research Software Engineer (RSE) Award (R50 Clinical Trials Not Allowed)
- Intervention Research to Improve Native American Health (R01 Clinical Trial Optional)
- HEAL Initiative: Studies to Enable Analgesic Discovery (R61/R33 - Clinical Trial Not Allowed)
- Biomedical Research Environment and Sponsored Programs Administration Development (BRE-SPAD) Program (UC2- Clinical Trial Not Allowed)
- NIAMS Clinical Trial Implementation Cooperative Agreement (UG3/UH3 Clinical Trial Required)
- NIH, CDC and FDA Small Business Innovation Research Grant (Parent SBIR [R43/R44] Clinical Trial Optional)
- NIH Small Business Technology Transfer Grant (Parent STTR [R41/R42] Clinical Trial Optional)
- Emergency Competitive Revision to Existing NIH Awards (Emergency Supplement - Clinical Trial Optional)
- Mentored Quantitative Research Development Award (Parent K25 Independent Clinical Trial Not Allowed)
- Mentored Research Scientist Development Award (Parent K01 - Independent Clinical Trial Required)
- Mentored Research Scientist Development Award (Parent K01 - Independent Clinical Trial Not Allowed)
- NIH Pathway to Independence Award (Parent K99/R00 Independent Clinical Trial Not Allowed)
- NIH Pathway to Independence Award (Parent K99/R00 Independent Clinical Trial Required)
- Midcareer Investigator Award in Patient-Oriented Research (Parent K24 Independent Clinical Trial Required)
- Midcareer Investigator Award in Patient-Oriented Research (Parent K24 Independent Clinical Trial Not Allowed)
- Mentored Patient-Oriented Research Career Development Award (Parent K23 Independent Clinical Trial Required)
- Mentored Clinical Scientist Research Career Development Award (Parent K08 Independent Clinical Trial Not Allowed)
- Change of Recipient Organization (Type 7 Parent Clinical Trial Optional)
- Successor-in-Interest (Type 6 Parent Clinical Trial Optional)
- NIH Support for Conferences and Scientific Meetings (Parent R13 Clinical Trial Not Allowed)
- Limited Competition: Clinical and Translational Science Award (CTSA) Program: Collaborative and Innovative Acceleration Award (UG3/UH3 Clinical Trial Optional)
- Limited Competition: CCRP Initiative: Promoting a Basic Understanding of Chemical Threats to Skin (R34 Clinical Trial Not Allowed)
Rules from the program listing
Who can apply
Research Grants: Individuals and public and private institutions, both nonprofit and for-profit, who propose to establish, expand, and improve research activities in health sciences and related fields. National Research Service Awards: Individuals must be nominated and sponsored by a public or private, for-profit or nonprofit institution having staff and facilities appropriate to the proposed research training program. All awardees must be citizens or have been admitted to the United States for permanent residence. To be eligible, predoctoral awardees must have completed the baccalaureate degree and postdoctoral awardees must have a professional or scientific degree (M.D., Ph.D., D.D.S., D.O., D.V.M., Sc.D., D. Eng., or equivalent domestic or foreign degree). Nonprofit domestic organizations may apply for the Institutional National Research Service grant. Small Business Innovation Research grants can be awarded only to domestic small businesses (entities that are independently owned and operated for profit, are not dominant in the field in which research is proposed, and have no more than 500 employees). Primary employment (more than one-half time) of the principal investigator must be with the small business at the time of award and during the conduct of the proposed project. In both Phase I and Phase II, the research must be performed in the U.S. or its possessions.
What the money can and cannot pay for
Research Grants provide funds for salaries, equipment, supplies, travel, and other expenses associated with scientific investigation relevant to program objectives. Individual National Research Service Awards (NRSAs) are made to individuals for research training in specified biomedical shortage areas. In addition, grants may be made to institutions to enable them to make NRSAs to individuals selected by them. Each individual who receives a NRSA is obligated upon termination of the award to comply with certain service and payback provisions. Small Business Innovation Research Phase I grants (of approximately 6-months' duration) are to establish the technical merit and feasibility of a proposed research effort that may lead to a commercial product or process. Phase II grants are for the continuation of the research initiated in Phase I that are likely to result in commercial products or processes. Only Phase I awardees are eligible to receive Phase II support. STTR Phase I grants (normally of 1-year duration) are to determine the scientific, technical, and commercial merit and feasibility of the proposed cooperative effort that has potential for commercial application. Phase II funding is based on results of research initiated in Phase I and scientific and technical merit and commercial potential on Phase II application.
Matching requirements
This program has no statutory formula. Matching requirements are not applicable to this assistance listing. MOE requirements are not applicable to this assistance listing.
Deadlines
Contact the headquarters or regional location, as appropriate for application deadlines
Award range and average, in the agency's words
Research Grants: $1 to $1,937050/Average Size: $361,815 National Research Service Awards: $5,496 to $691,170/Average Size: $157,706; SBIR: Phase 1 awards -- approximately $271,375; Phase II awards --approximately $859,296; STTR: Phase 1 awards -- approximately $273,335; Phase II awards --approximately $811,438.
Funding history and past recipients
From fiscal 2021 to 2025, Arthritis, Musculoskeletal and Skin Diseases Research (93.846) awarded$2.6 billion across 2,898 grant awards, an average of $908,452 per award.
Who usually wins
Colleges and universities received 74% of the money, nonprofits 19% and small businesses 3.7%.
| Recipient type | Awards | Amount | Share |
|---|---|---|---|
| Colleges and universities | 2,087 | $2.0 billion | 74% |
| Nonprofits | 568 | $502 million | 19% |
| Small businesses | 153 | $98.5 million | 3.7% |
| Other | 88 | $76.3 million | 2.9% |
| Tribal governments and organizations | 1 | $1.1 million | less than 0.1% |
| State and local governments | 1 | $674,665 | less than 0.1% |
By state
Each state below has its own page for this program, with its recipients and yearly totals.
| State | Awards | Amount |
|---|---|---|
| California | 349 | $338 million |
| New York | 302 | $315 million |
| Massachusetts | 311 | $310 million |
| Pennsylvania | 239 | $225 million |
| North Carolina | 135 | $118 million |
| Illinois | 109 | $101 million |
| Connecticut | 97 | $96.0 million |
| Texas | 103 | $87.3 million |
| Michigan | 93 | $86.4 million |
| Ohio | 94 | $80.5 million |
| Minnesota | 89 | $80.1 million |
| Missouri | 102 | $79.6 million |
| Washington | 60 | $79.0 million |
| Maryland | 103 | $74.1 million |
| Colorado | 68 | $62.0 million |
| Florida | 63 | $58.0 million |
| Virginia | 46 | $39.5 million |
| Georgia | 47 | $35.1 million |
| Indiana | 44 | $34.7 million |
| Oklahoma | 22 | $32.3 million |
| Alabama | 30 | $31.7 million |
| Tennessee | 44 | $26.2 million |
| Oregon | 31 | $25.9 million |
| Arizona | 24 | $21.5 million |
| Utah | 26 | $21.3 million |
| Wisconsin | 30 | $21.1 million |
| South Carolina | 27 | $20.2 million |
| New Jersey | 22 | $17.5 million |
| Kentucky | 18 | $14.0 million |
| Rhode Island | 42 | $10.8 million |
| Maine | 13 | $10.5 million |
| Iowa | 17 | $10.0 million |
| New Hampshire | 11 | $9.6 million |
| District of Columbia | 12 | $9.2 million |
| Delaware | 14 | $8.2 million |
| Nebraska | 11 | $7.2 million |
| Arkansas | 10 | $6.9 million |
| Nevada | 4 | $5.7 million |
| Louisiana | 8 | $4.8 million |
| Vermont | 7 | $4.0 million |
| Kansas | 7 | $3.7 million |
| Montana | 3 | $3.0 million |
| West Virginia | 4 | $2.4 million |
| Mississippi | 2 | $1.5 million |