PAR-24-305: Centers for Precision Disease Modeling (U54) (Clinical Trials Not Allowed)
Closed
This grant is closed. Who won this program's grants before is below, and similar open grants are at the end of the page. It is in our archive of National Institutes of Health notices from 2024.
National Institutes of Health offered grants to nonprofits, colleges and universities, state and local governments, tribes, small businesses and businesses. Applications closed on December 15, 2024.
From the official notice on Grants.gov, last changed October 4, 2024. Checked November 7, 2026.
- Award amountsNot given on Grants.gov
- Cost sharingNot required
- Funding typeCooperative Agreement
About this NIH notice
- Activity codeU54
- Clinical trialsNot allowed
- Funded byOD
- Median yearly award$398,702
- Typical project length10 years
- U54, Specialized Center Cooperative Agreement. A research center with several projects and shared cores, with substantial NIH involvement. Other open U54 notices.
Projects funded under PAR-24-305 were run by NIH Office of the Director (OD, 4 projects). Contact the program officer at the institute that fits your project before you apply; the notice lists them.
Application due dates, page limits and budget limits are set in the notice. Read PAR-24-305 in the NIH Guide.
Key dates
| Posted | October 4, 2024 |
|---|---|
| Deadline | December 15, 2024 |
| Archived by Grants.gov | January 20, 2025 |
Who can apply
This opportunity was open to nonprofits, colleges and universities, state and local governments, tribes, small businesses and businesses.
All 15 applicant types the notice lists
- State governments
- County governments
- City or township governments
- Special district governments
- Independent school districts
- Public and State controlled institutions of higher education
- Native American tribal governments (Federally recognized)
- Public housing authorities/Indian housing authorities
- Native American tribal organizations (other than Federally recognized tribal governments)
- Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education
- Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education
- Private institutions of higher education
- For profit organizations other than small businesses
- Small businesses
- Others (see text field entitled "Additional Information on Eligibility" for clarification)
Other Eligible Applicants include the following: Alaska Native and Native Hawaiian Serving Institutions; Asian American Native American Pacific Islander Serving Institutions (AANAPISISs); Eligible Agencies of the Federal Government; Faith-based or Community-based Organizations; Hispanic-serving Institutions; Historically Black Colleges and Universities (HBCUs); Indian/Native American Tribal Governments (Other than Federally Recognized); Non-domestic (non-U.S.) Entities (Foreign Organizations); Regional Organizations; Tribally Controlled Colleges and Universities (TCCUs) ; U.S. Territory or Possession; Non-domestic (non-U.S.) Entities (Foreign Organization) are not eligible to apply. Non-domestic (non-U.S.) components of U.S. Organizations are not eligible to apply. Foreign components, as defined in the NIH Grants Policy Statement, are not allowed.
Is this a realistic fit?
- Most of the program's money (80% over five years) went to colleges and universities.
- No cost sharing or match is required.
What the grant funds
This Notice of Funding Opportunity (NOFO) invites U54 cooperative agreement applications for the support and advancement of the Centers for Precision Disease Modeling. The goal of the Centers is to support collaborative research projects that bridge current personalized medicine efforts in human subjects with advances in animal genomics and genetic manipulation technologies, including the creation of interspecies somatic hybrids. By functionally linking these areas of research, the Centers aim to enhance the predictive value of preclinical studies through the use of precision animal models. Each Center will develop a process by which the research community can nominate unique human genomic variants for cost effective high-throughput testing in an animal model pipeline. After validation of the expected gene editing, the Centers will support assays to conduct comprehensive functional and phenotyping analyses to evaluate disease-causing variants. A key mission of the Centers is the creation and distribution of precision animal model resources and related services to the biomedical community. Therefore, Centers will establish pipelines for preclinical scientific discovery, disease modeling, and development of interventions based on innovative animal models. While the Centers will focus on a limited number of targeted projects, they are expected to develop and maintain multifaceted research activities that can be adjusted to accommodate a wide range of diseases.
Funded under PAR-24-305 so far
NIH funded 4 projects under PAR-24-305 in fiscal 2025 to 2026, at 4 institutions. The median yearly award was $398,702.
| Project | Institution | Fiscal year | Award |
|---|---|---|---|
| Coordination Section | Baylor College of Medicine | 2026 | $169,440 |
| Coordination Section | Jackson Laboratory | 2026 | $271,077 |
| Center for Modeling Non-Coding Disease Variants | University of California-Irvine | 2026 | $1.8 million |
| UAB Center for Precision Animal Modeling (CPAM) | University of Alabama at Birmingham | 2026 | $1.8 million |
Who has won Research Infrastructure Programs grants before
From fiscal 2021 to 2025, Research Infrastructure Programs (93.351) awarded $1.4 billion across 1,102 grant awards, an average of $1.3 million per award.
| Recipient | State | Awards | Amount |
|---|---|---|---|
| University of California, Davis | California | 27 | $102 million |
| Oregon Health & Science University | Oregon | 18 | $92.1 million |
| University of Washington | Washington | 7 | $79.5 million |
| Emory University | Georgia | 14 | $78.3 million |
| The Administrators of Tulane Educational Fund | Louisiana | 10 | $68.0 million |
Applying now
This notice no longer takes applications. Agencies often post the same opportunity again under a new number, so check the program's notices on Grants.gov and the similar open grants below.
The notice on Grants.gov keeps its full text and attachments, which is useful for planning a resubmission.
Questions people ask
Is PAR-24-305 still open?
No. It closed on December 15, 2024.
Who can apply for Centers for Precision Disease Modeling (U54) (Clinical Trials Not Allowed)?
National Institutes of Health accepted applications from nonprofits, colleges and universities, state and local governments, tribes, small businesses and businesses. The notice adds further conditions, so read its eligibility section.
What is the deadline for Centers for Precision Disease Modeling (U54) (Clinical Trials Not Allowed)?
Closed December 15, 2024. Applications are no longer accepted; the program's newer notices are on this page when there are any.
Who has been funded under PAR-24-305?
NIH RePORTER lists 4 projects funded under PAR-24-305 in fiscal 2025 to 2026, at 4 institutions. The most were at Baylor College of Medicine, Jackson Laboratory, University of California-Irvine.
Who has won Research Infrastructure Programs grants before?
The largest recipients over five fiscal years were University of California, Davis, Oregon Health & Science University, University of Washington. The program made 1,102 awards worth $1.4 billion in that time.
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