Grants / Department of Health and Human Services / National Institutes of Health

Limited Competition: The NHGRI Analysis, Visualization, and Informatics Lab-space (AnVIL) (U54 Clinical Trial Not Allowed)

Forecast Expected deadline May 25, 2027 Opportunity RFA-HG-28-005

• Award ceilingnot stated
• Award floornot stated
• Expected awards1
• Total funding$8.0 million
• Cost sharingNot required
• Funding typeCooperative Agreement

Key dates

Add the deadline to your calendar

Who can apply

This opportunity is open to nonprofits, colleges and universities, state and local governments, tribes, small businesses and businesses.

• State governments
• County governments
• City or township governments
• Special district governments
• Independent school districts
• Public and State controlled institutions of higher education
• Native American tribal governments (Federally recognized)
• Public housing authorities/Indian housing authorities
• Native American tribal organizations (other than Federally recognized tribal governments)
• Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education
• Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education
• Private institutions of higher education
• For profit organizations other than small businesses
• Small businesses
• Others (see text field entitled "Additional Information on Eligibility" for clarification)

Other Eligible ApplicantsIndian/Native American Tribal Governments (Other than Federally Recognized);Eligible Agencies of the Federal Government;U.S. Territory or Possession;Faith-based or Community-based Organizations;Regional Organizations;Non-domestic (non-U.S.) Entities (Foreign Institutions).

More grants for nonprofits, colleges and universities, state and local governments, tribes, small businesses, businesses.

Is this a realistic fit?

• No cost sharing or match is required.

What the grant funds

The National Human Genome Research Institute (NHGRI) intends to issue a Notice of Funding Opportunity (NOFO) to support a limited competition renewal of the Analysis, Visualization, and Informatics Lab-space (AnVIL) program. AnVIL is a secure, cloud-based platform that enables researchers to access, share, and analyze large-scale genomic datasets without relying on local infrastructure. Currently, AnVIL hosts more than 5 petabytes of data from nearly 300,000 research participants, providing a robust environment for reproducible, cloud-native genomic research. The renewed program will continue to advance AnVIL as a community resource grounded in FAIR (Findable, Accessible, Interoperable, and Reusable) principles. Key priorities include enhancing scalability; strengthening interoperability across a federated NIH data ecosystem; and maintaining rigorous security aligned with the Research Authentication Service (RAS) and NIH controlled-access data repositories and access management systems (CADR) requirements (see NOT‑OD‑25‑159). The renewal will also support integration of emerging data types and computational tools, including infrastructure for developing and running AI-based methods and complex analysis workflows. In addition to platform development, the program will expand training and outreach to help researchers effectively use AnVIL’s multimodal datasets and reproducible analysis capabilities. By connecting secure data access, analytical tools, and workforce development, the renewed AnVIL program aims to accelerate discovery across the research lifecycle and strengthen the genomics community’s capacity for clinical and translational science. This Notice is being provided to allow potential applicants sufficient time to develop responsive applications. The NOFO is expected to be published in 2027 with an anticipated application due date in 2027. This NOFO will utilize the U54 activity code. This is a Forecast for a limited competition that will invite application(s) from eligible organization(s) to apply. Please see Eligibility Section for additional information. In accordance with NIH standard peer-review processes, the application(s) will be peer-reviewed, and only meritorious application(s) will be considered for funding.

Category: Health.

How to apply

1. Read the full notice and attachments on Grants.gov. The notice is the official source for deadlines and requirements.
2. Make sure your organization has an active SAM.gov registration and Unique Entity ID; registration can take several weeks.
3. Register on Grants.gov and submit through Workspace before the deadline and time given in the notice. Our application guide walks through each step.

Questions go to Office of the Director / Office of Genomic Data Science, anvil@mail.nih.gov, Please contact via e-mail..

Open the official notice