Human Genome Research (93.172)
Human Genome Research (Assistance Listing 93.172) is run by the National Institutes of Health, part of the Department of Health and Human Services. It awarded $2.2 billion in 1,255 grants from fiscal 2021 to 2025, about $1.7 million per award on average. 64 funding opportunities are open or forecast now.
The typical award was $736,664. Half of the 1,255 awards fell between $320,623 and $2.0 million, and they ranged from $0 to $24.9 million.
- Awarded, FY 2021 to 2025$2.2 billion
- Grant awards1,255
- Typical award$736,664
- Awarded in FY 2025$421 million
- Size rank152 of 1,823
- Type of assistanceProject grants
Key findings
- Annual funding was roughly flat, $427 million in fiscal 2021 and $421 million in fiscal 2025.
- It is the 152nd largest of 1,823 federal grant programs by five-year awards.
- The 20 largest recipients received 53% of the money.
- Awards went to recipients in 45 states and territories.
What the program funds
As a leading authority in the field of genomics, the mission of the National Human Genome Research Institute (NHGRI) is to accelerate scientific and medical breakthroughs that improve human health by driving cutting-edge research, developing new technologies, and studying the impact of genomics on society. Congress initially established NHGRI to characterize the structure and function of the human genome, including the mapping and sequencing of individual genes. This also includes reviewing and funding research proposals, developing training programs, coordinating international genome research, communicating advances in genome science to the public, and reviewing and funding proposals to address the ethical and legal issues associated with this research. NHGRI supports the development of methods, resources and technologies to improve the health of all humans through advances in genomics research. NHGRI supports research that accelerates foundational resources, technology development, and experimental and computational approaches for basic genomics and functional genomics research; for the application of genomics to medical science and clinical care; and to support ethical, legal and social implications (ELSI) research concerning societal issues that need to be addressed, especially as genomic science advances. For years, NHGRI has participated in the NIH effort to turn discovery into health by helping small businesses develop innovative genomics technologies that improve health and save lives. NHGRI also develops and supports initiatives that expand opportunities for genomics education and careers, cultivating genomics training programs and workforce development initiatives.
Open and forecast opportunities
- Ethical, Legal and Social Implications (ELSI) Small Research Grant (R03 Clinical Trial Optional)
- Secondary Analysis and Integration of Existing Data to Elucidate Cancer Risk and Related Outcomes (R21 Clinical Trials Not Allowed)
- Ethical, Legal and Social Implications (ELSI) Exploratory/Developmental Research Grant (R21 Clinical Trial Optional)
- Ethical, Legal and Social Implications (ELSI) Research (R01 Clinical Trial Optional)
- Competing Revisions to Existing NIH Single Project Research Grants and Cooperative Agreements (Clinical Trial Optional)
- Emerging Global Leader Award (K43 Independent Clinical Trial Not Allowed)
- Emerging Global Leader Award (K43 Independent Clinical Trial Required)
- NIH Research Software Engineer (RSE) Award (R50 Clinical Trials Not Allowed)
- Systematic Characterization of Genomic Variation to Assess Effects of Individual Variants on Genome Function and Phenotype (UM1 Clinical Trials Not Allowed)
- IGVF Data and Coordinating Center (U24 Clinical trials Not Allowed)
- Computational Modeling and Analysis of the Impact of Genomic Variation on Function (UM1, Clinical Trial Not Allowed)
- Genomic Variant Interactions With Other Variants Or The Environment (UM1 Clinical Trials Not Allowed)
- Developing novel theory and methods for understanding the genetic architecture of complex human traits (R21 Clinical Trial Not Allowed)
- Systems Biology of Infection and Inflammation in Chronic Diseases (U19 Clinical Trial Not Allowed)
- Supporting Talented Early Career Researchers in Genomics (R01 Clinical Trial Optional)
- NIH, CDC and FDA Small Business Innovation Research Grant (Parent SBIR [R43/R44] Clinical Trial Optional)
- NIH Small Business Technology Transfer Grant (Parent STTR [R41/R42] Clinical Trial Optional)
- Mentored Quantitative Research Development Award (Parent K25 Independent Clinical Trial Not Allowed)
- Mentored Research Scientist Development Award (Parent K01 - Independent Clinical Trial Required)
- Mentored Research Scientist Development Award (Parent K01 - Independent Clinical Trial Not Allowed)
- NIH Pathway to Independence Award (Parent K99/R00 Independent Clinical Trial Not Allowed)
- NIH Pathway to Independence Award (Parent K99/R00 Independent Clinical Trial Required)
- Mentored Clinical Scientist Research Career Development Award (Parent K08 Independent Clinical Trial Required)
- Mentored Clinical Scientist Research Career Development Award (Parent K08 Independent Clinical Trial Not Allowed)
- Change of Recipient Organization (Type 7 Parent Clinical Trial Optional)
Past notices
Of 240 notices posted under this program since 2021, most went up in June (28), August (27) and April (24).
- RFA-HG-27-011: GREGoRi Data Coordination and Outreach Center (U01, Clinical Trials Not Allowed)
- RFA-HG-27-012: GREGoRi Technology Integration Center (U01, Clinical Trials Optional)
- RFA-HG-27-013: GREGoRi Innovation Projects (U01 Clinical Trial Optional)
- RFA-HG-26-008: Single Source: Outcomes of Electronic Medical Records and Genomics (eMERGE) Genomic Risk Assessment and Management Network - Coordinating Center (U01 Clinical Trial Required)
- RFA-HG-25-012: Limited Competition: Outcomes of Electronic Medical Records and Genomics (eMERGE) Genomic Risk Assessment and Management Network - Clinical Sites (U01, Clinical Trial Required)
- PAR-25-438: Rare Diseases Clinical Research Consortia (RDCRC) for the Rare Diseases Clinical Research Network (RDCRN) (U54 Clinical Trial Optional)
- PAR-25-097: Small Grants for New Investigators to Broaden Participation in Health-Related Research (R21 Clinical Trial Optional)
- PAR-25-308: Small Business Informatics Tools for the Pangenome (R43 Clinical Trial Not Allowed)
- PAR-25-309: Small Business Informatics Tools for the Pangenome (R41 Clinical Trial Not Allowed)
- RFA-HG-25-007: Informatics Tools for the Pangenome (U01 Clinical Trial Not Allowed)
- PAS-25-190: Research Opportunities for New and "At-Risk" Investigators to Promote Workforce Diversity (R01 Clinical Trial Optional)
- RFA-HG-25-002: Advancing Genomic Medicine Research (R01 Clinical Trial Optional)
- RFA-HG-25-003: Advancing Genomic Medicine Research (R21 Clinical Trial Optional)
- RFA-HG-25-004: Advancing Genomic Medicine Research (R03 Clinical Trial Not Allowed)
- PAR-25-095: Secondary Analysis and Integration of Existing Data to Elucidate Cancer Risk and Related Outcomes (R01 Clinical Trial Not Allowed)
Rules from the program listing
Who can apply
Awards can be made to any public or private, for-profit or nonprofit university; college; medical, dental, nursing school; school of public health; hospital; laboratory; or other institution; state and local health departments; other public or private institutions, both for-profit and non-profit; and/or to individuals. National Research Service Award, Institutional Awards: Non-federal public and private domestic organizations may apply. All awardees must be citizens or have been admitted to the United States for permanent residence. Predoctoral awardees must have completed the baccalaureate degree, and postdoctoral awardees must have a professional or scientific degree (M.D., Ph.D., D.O., D.V.M., Sc.D., E.Eng., or equivalent domestic or foreign degree). National Research Service Award. Individual Awardees must be nominated and sponsored by a public or nonprofit private institution having staff and facilities appropriate to the proposed research training program. The applicant's academic record, research experience, citizenship, and institution sponsorship should be documented in the application. All awardees must be citizens or have been admitted to the United States for permanent residence. Predoctoral awardees must have completed the baccalaureate degree, and postdoctoral awardees must have a professional or scientific degree (M.D., Ph.D., D.O., D.V.M., Sc.D., E.Eng., or equivalent domestic or foreign degree).
What the money can and cannot pay for
Grants are awarded to an eligible institution in the name of a principal investigator for a discrete project or group of related projects representing the investigator's interest and competence. Funds may be used for salaries and wages, equipment, supplies, travel and other allowable costs required to carry out the research project. Awardees agree to administer awards in accordance with the regulations and policies governing research assistance programs in the Public Health Service Act, as stated in the NIH Grants Policy Statement and the terms and conditions in the notice of award. Institutional Training Grants are awarded to an eligible institution in the name of a principal investigator for a discrete project or group of related projects representing the investigator's interest and competence. Funds may be used for salaries and wages, equipment, supplies, travel and other allowable costs required to carry out the research project. Awardees agree to administer awards in accordance with the regulations and policies governing research assistance programs in the Public Health Service Act, as stated in the NIH Grants Policy Statement and the terms and conditions in the notice of award. National Research Service Awards institutional training grants may be made to institutions to enable them to select individuals for National Research Service Awards. Each individual who receives a National Research Service Award is responsible for certain service and payback provisions.
Matching requirements
This program has no statutory formula. Matching requirements are not applicable to this assistance listing. MOE requirements are not applicable to this assistance listing.
Deadlines
Requests for Applications and Program Announcements for Special Review or Set Aside are not necessarily submitted on standard due dates. The submission dates of these funding opportunity announcements can be found at: https://grants.nih.gov/funding/nih-guide-for-grants-and-contracts
Award range and average, in the agency's words
For Research project grants the range is from $26,000 - $19,996,553.
Examples of funded projects
Fiscal Year2025: Examples of research supported by NHGRI in FY 2025 include characterization of genes, sequencing, databases, and projects on the following list: https://reporter.nih.gov/search/KP6XtPborUWv7kYNeFlJSA/projects?shared=trueFiscal Year2026: Current projects supported by NHGRI include basic genomic science; functional and clinical variation; genomic medicine; technology development; computational genomics and data science; training programs; conferences; databases; determining the ethical, legal, and social implications (ELSI) of biomedical and behavioral research; as well as projects on the following list: https://reporter.nih.gov/search/PbojAWqEZ0aySDrGRZXHTg/projects?shared=true
Funding history and past recipients
From fiscal 2021 to 2025, Human Genome Research (93.172) awarded $2.2 billion across 1,255 grant awards, an average of $1.7 million per award.
Who usually wins
Colleges and universities received 67% of the money, nonprofits 25% and small businesses 3.8%.
| Recipient type | Awards | Amount | Share |
|---|---|---|---|
| Colleges and universities | 827 | $1.5 billion | 67% |
| Nonprofits | 255 | $535 million | 25% |
| Other | 57 | $89.4 million | 4.1% |
| Small businesses | 111 | $82.1 million | 3.8% |
| State and local governments | 2 | $2.4 million | 0.1% |
| Tribal governments and organizations | 2 | $2.0 million | less than 0.1% |
| Businesses | 1 | $186,512 | less than 0.1% |
By state
39 states have a page for this program: those that received at least $1 million or 10 awards.
| State | Awards | Amount |
|---|---|---|
| California | 249 | $470 million |
| Massachusetts | 162 | $350 million |
| New York | 128 | $193 million |
| Washington | 60 | $145 million |
| North Carolina | 59 | $119 million |
| Texas | 53 | $101 million |
| Pennsylvania | 72 | $93.9 million |
| Maryland | 47 | $67.6 million |
| Illinois | 44 | $62.5 million |
| Tennessee | 33 | $59.1 million |
| Maine | 16 | $53.4 million |
| Connecticut | 33 | $51.4 million |
| Missouri | 23 | $46.6 million |
| Ohio | 30 | $41.9 million |
| Florida | 17 | $28.9 million |
| Oregon | 8 | $28.2 million |
| Colorado | 22 | $23.1 million |
| Utah | 21 | $22.7 million |
| Michigan | 28 | $22.7 million |
| Minnesota | 15 | $20.6 million |
| Alabama | 8 | $15.1 million |
| Wisconsin | 11 | $13.7 million |
| New Jersey | 6 | $13.3 million |
| Georgia | 5 | $10.8 million |
| Arizona | 11 | $9.1 million |
| Indiana | 6 | $8.4 million |
| Hawaii | 4 | $6.2 million |
| Oklahoma | 3 | $4.0 million |
| Virginia | 5 | $4.0 million |
| Kentucky | 3 | $3.5 million |
| Iowa | 2 | $3.0 million |
| Rhode Island | 9 | $2.4 million |
| New Mexico | 2 | $2.2 million |
| Montana | 3 | $1.7 million |
| District of Columbia | 1 | $1.6 million |
| Alaska | 1 | $1.4 million |
| Mississippi | 1 | $1.3 million |
| Puerto Rico | 1 | $1.3 million |
| South Dakota | 3 | $1.2 million |
| Delaware | 2 | $690,601 |
| New Hampshire | 2 | $449,286 |
| Nevada | 1 | $398,526 |
| Kansas | 1 | $342,831 |
| South Carolina | 1 | $278,076 |
| Vermont | 1 | $25,839 |