Well Told Grants

Grants / Department of Health and Human Services / National Institutes of Health

RFA-RM-21-008: Cellular Senescence Network: Tissue Mapping Centers (U54 Clinical Trial Not Allowed)

Closed Closed March 22, 2021 Opportunity RFA-RM-21-008

This grant is closed. Who won this program's grants before is below, and similar open grants are at the end of the page. It is in our archive of National Institutes of Health notices from 2021.

National Institutes of Health offered grants to nonprofits, colleges and universities, state and local governments, tribes, small businesses and businesses. Applications closed on March 22, 2021.

From the official notice on Grants.gov, last changed January 25, 2021. Checked November 7, 2026.

About this NIH notice

Projects funded under RFA-RM-21-008 were run by National Institute on Aging (NIA, 8 projects). Contact the program officer at the institute that fits your project before you apply; the notice lists them.

Application due dates, page limits and budget limits are set in the notice. Read RFA-RM-21-008 in the NIH Guide.

Key dates

PostedJanuary 6, 2021
DeadlineMarch 22, 2021
Archived by Grants.govApril 21, 2021

Who can apply

This opportunity was open to nonprofits, colleges and universities, state and local governments, tribes, small businesses and businesses.

All 15 applicant types the notice lists

Other Eligible Applicants include the following: Alaska Native and Native Hawaiian Serving Institutions; Asian American Native American Pacific Islander Serving Institutions (AANAPISISs); Eligible Agencies of the Federal Government; Faith-based or Community-based Organizations; Hispanic-serving Institutions; Historically Black Colleges and Universities (HBCUs); Indian/Native American Tribal Governments (Other than Federally Recognized); Non-domestic (non-U.S.) Entities (Foreign Organizations); Regional Organizations; Tribally Controlled Colleges and Universities (TCCUs) ; U.S. Territory or Possession; Non-domestic (non-U.S.) Entities (Foreign Institutions) are not eligible to apply. Non-domestic (non-U.S.) components of U.S. Organizations are not eligible to apply. Foreign components, as defined in the NIH Grants Policy Statement, are allowed.

More grants for nonprofits, colleges and universities, state and local governments, tribes, small businesses, businesses.

Is this a realistic fit?

What the grant funds

The purpose of this Funding Opportunity Announcement (FOA) is to establish state-of-the-art Tissue Mapping Centers (TMCs) to work within the Cellular Senescence Network (SenNet). The goal of the SenNet consortium is to identify and functionally characterize the heterogeneity of senescent cells across multiple tissues in human health, disease, and lifespan at single-cell resolution. Through collaborative efforts, the consortium will generate a multimodal, multidimensional Atlas of senescent cells in various human tissues; develop innovative tools and technologies to identify and characterize senescent cells; and aggregate data across the Network into a searchable Atlas of Cellular Senescence, ensure the utility of the database, and promote collaboration through Network engagement with the research community. The TMCs solicited through this RFA will generate the high-resolution, high-content, multiscale biomarkers and maps of cellular senescence across the lifespan and physiological states necessary to generate the Senescence Atlas. The SenNet is focused on healthy human tissues, and work in diseased tissue or animal models is acceptable only as long as it is used to support this overall goal. TMCs will be expected to integrate and optimize all parts of the data generation pipeline, from tissue collection and preservation through analyses at organ, tissue and single cell level using omics, imaging and other approaches, to data integration, analysis and interpretation.

Category: Health.

Funded under RFA-RM-21-008 so far

NIH funded 8 projects under RFA-RM-21-008 in fiscal 2021 to 2025, at 8 institutions. The median yearly award was $548,061.

Recently funded projects
ProjectInstitutionFiscal yearAward
Biological Analysis Core U54Duke University2025$731,785
WU-SN-TMC Bio-Analysis Core U54Washington University2025$845,309
Biospecimen Core U54Columbia University Health Sciences2025$455,184
Core D: Data Analysis Core U54Yale University2025$324,645
Data-Analysis-Core U54University of Pittsburgh at Pittsburgh2025$512,308
Biospecimen Core for Procurement of Human Somatic and Reproductive Tissues for Senescent Cell Mapping U54Buck Institute for Research on Aging2025$462,450
The KAPP-Sen Tissue Mapping Center Collaborative U54University of Connecticut Sch of Med/DNT2025$2.7 million
Minnesota Tissue Mapping Center for Senescent Cells U54University of Minnesota2025$1.7 million

From NIH RePORTER, which lists each project once per fiscal year it was funded. Amounts are the yearly award.

Who has won Trans-NIH Research Support grants before

From fiscal 2021 to 2025, Trans-NIH Research Support (93.310) awarded $5.9 billion across 4,433 grant awards, an average of $1.3 million per award.

Largest recipients, fiscal 2021 to 2025
RecipientStateAwardsAmount
Duke UniversityNorth Carolina66$219 million
The Leland Stanford Junior UniversityCalifornia104$176 million
University of Pittsburgh - of the Commonwealth System of Higher EducationPennsylvania82$154 million
The Johns Hopkins UniversityMaryland95$152 million
Yale UnivConnecticut85$149 million

Top states: California ($992 million), Massachusetts ($571 million), New York ($548 million), Pennsylvania ($445 million), North Carolina ($387 million).

Applying now

This notice no longer takes applications. Agencies often post the same opportunity again under a new number, so check the program's notices on Grants.gov and the similar open grants below.

The notice on Grants.gov keeps its full text and attachments, which is useful for planning a resubmission.

Questions people ask

Is RFA-RM-21-008 still open?

No. It closed on March 22, 2021.

Who can apply for Cellular Senescence Network: Tissue Mapping Centers (U54 Clinical Trial Not Allowed)?

National Institutes of Health accepted applications from nonprofits, colleges and universities, state and local governments, tribes, small businesses and businesses. The notice adds further conditions, so read its eligibility section.

What is the deadline for Cellular Senescence Network: Tissue Mapping Centers (U54 Clinical Trial Not Allowed)?

Closed March 22, 2021. Applications are no longer accepted; the program's newer notices are on this page when there are any.

Who has been funded under RFA-RM-21-008?

NIH RePORTER lists 8 projects funded under RFA-RM-21-008 in fiscal 2021 to 2025, at 8 institutions. The most were at Duke University, Washington University, Columbia University Health Sciences.

Who has won Trans-NIH Research Support grants before?

The largest recipients over five fiscal years were Duke University, The Leland Stanford Junior University, University of Pittsburgh - of the Commonwealth System of Higher Education. The program made 4,433 awards worth $5.9 billion in that time.

Similar open grants