RFA-CA-21-048: Research Centers for Cancer Systems Biology (U54 Clinical Trial Not Allowed)
Closed
This grant is closed. Who won this program's grants before is below, and similar open grants are at the end of the page. It is in our archive of National Institutes of Health notices from 2021.
National Institutes of Health offered grants of up to $1.5 million to nonprofits, colleges and universities, state and local governments, tribes, small businesses and businesses. Applications closed on October 19, 2022.
From the official notice on Grants.gov, last changed July 30, 2021. Checked November 7, 2026.
- Award ceiling$1.5 million
- Cost sharingNot required
- Funding typeCooperative Agreement
About this NIH notice
- Activity codeU54
- Clinical trialsNot allowed
- Funded byNCI
- Median yearly award$373,133
- Typical project length5 years
- U54, Specialized Center Cooperative Agreement. A research center with several projects and shared cores, with substantial NIH involvement. Other open U54 notices.
Projects funded under RFA-CA-21-048 were run by National Cancer Institute (NCI, 9 projects). Contact the program officer at the institute that fits your project before you apply; the notice lists them.
Application due dates, page limits and budget limits are set in the notice. Read RFA-CA-21-048 in the NIH Guide.
Key dates
| Posted | July 28, 2021 |
|---|---|
| Deadline | October 19, 2022 |
| Archived by Grants.gov | November 24, 2022 |
Who can apply
This opportunity was open to nonprofits, colleges and universities, state and local governments, tribes, small businesses and businesses.
All 15 applicant types the notice lists
- State governments
- County governments
- City or township governments
- Special district governments
- Independent school districts
- Public and State controlled institutions of higher education
- Native American tribal governments (Federally recognized)
- Public housing authorities/Indian housing authorities
- Native American tribal organizations (other than Federally recognized tribal governments)
- Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education
- Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education
- Private institutions of higher education
- For profit organizations other than small businesses
- Small businesses
- Others (see text field entitled "Additional Information on Eligibility" for clarification)
Other Eligible Applicants include the following: Alaska Native and Native Hawaiian Serving Institutions; Asian American Native American Pacific Islander Serving Institutions (AANAPISISs); Eligible Agencies of the Federal Government; Faith-based or Community-based Organizations; Hispanic-serving Institutions; Historically Black Colleges and Universities (HBCUs); Indian/Native American Tribal Governments (Other than Federally Recognized); Non-domestic (non-U.S.) Entities (Foreign Organizations); Regional Organizations; Tribally Controlled Colleges and Universities (TCCUs) ; U.S. Territory or Possession; Non-domestic (non-U.S.) Entities (Foreign Institutions) are not eligible to apply. Non-domestic (non-U.S.) components of U.S. Organizations are not eligible to apply. Foreign components, as defined in the NIH Grants Policy Statement, are allowed.
Is this a realistic fit?
- Projects NIH funded under this notice had a median yearly award of $373,133; it allows up to $1.5 million per award.
- Most of the program's money (69% over five years) went to colleges and universities.
- No cost sharing or match is required.
What the grant funds
The National Cancer Institutes (NCI) Cancer Systems Biology Consortium (CSBC, https://csbconsortium.org/) supports the application of systems biology approaches to cancer research and includes U01 Research Projects and, through this FOA, U54 Research Centers. These multi-project Centers should address challenges in basic cancer biology that would benefit from a coordinated systems biology approach and should coalesce around a well-defined overarching scientific theme pursued through two or three research projects. The research projects should be driven by a specific hypothesis and incorporate iterative cycles of quantitative experimentation, analysis, modeling, and validation in a disease-relevant context. Centers will include an interdisciplinary research team including quantitative and cancer biology expertise, administrative management, optional shared resource cores, and an Outreach core that support the overall Center research theme. Each Center will make sharing interoperable datasets and community accessible tools a priority with the support of a multi-consortium U24 Coordinating Center (being solicited under RFA-CA-21-049), actively collaborate within and outside the consortium, and support a welcoming and diverse research community at the Center and Consortium level.
Funded under RFA-CA-21-048 so far
NIH funded 9 projects under RFA-CA-21-048 in fiscal 2022 to 2026, at 9 institutions. The median yearly award was $373,133.
| Project | Institution | Fiscal year | Award |
|---|---|---|---|
| Project I: Systems analysis of tumor-stroma interactions in brain metastasis | Sloan-Kettering Inst Can Research | 2026 | $681,950 |
| Core 1: Mouse Model and Tissue Biobank Core | Institute for Systems Biology | 2026 | $416,279 |
| Core 1: Mathematical Core | H. Lee Moffitt Cancer Ctr & Res Inst | 2026 | $240,378 |
| Systems Analysis of Stress-adapted Cancer Organelles (SASCO) Center | University of Virginia | 2026 | $2.2 million |
| Outreach Core | Columbia University Health Sciences | 2026 | $304,519 |
| Systems Biology of Tumor-Immune-Stromal Interactions in Metastatic Progression | Stanford University | 2026 | $1.9 million |
| Project 3: From Networks and Structures to Hierarchical Whole Cell Models of Cancer | University of California, San Francisco | 2026 | $508,846 |
| Administrative Core | Massachusetts Institute of Technology | 2026 | $238,169 |
Who has won Cancer Biology Research grants before
From fiscal 2021 to 2025, Cancer Biology Research (93.396) awarded $4.3 billion across 3,142 grant awards, an average of $1.4 million per award.
| Recipient | State | Awards | Amount |
|---|---|---|---|
| The Trustees of Columbia University in the City of New York | New York | 70 | $151 million |
| The Univeristy of Texas M.D. Anderson Cancer Center | Texas | 109 | $144 million |
| Sloan-Kettering Institute for Cancer Research | New York | 66 | $136 million |
| Dana-Farber Cancer Institute, Inc. | Massachusetts | 47 | $107 million |
| The Regents of the University of California, San Francisco | California | 64 | $95.5 million |
Applying now
This notice no longer takes applications. Agencies often post the same opportunity again under a new number, so check the program's notices on Grants.gov and the similar open grants below.
The notice on Grants.gov keeps its full text and attachments, which is useful for planning a resubmission.
Questions people ask
Is RFA-CA-21-048 still open?
No. It closed on October 19, 2022.
Who can apply for Research Centers for Cancer Systems Biology (U54 Clinical Trial Not Allowed)?
National Institutes of Health accepted applications from nonprofits, colleges and universities, state and local governments, tribes, small businesses and businesses. The notice adds further conditions, so read its eligibility section.
What is the deadline for Research Centers for Cancer Systems Biology (U54 Clinical Trial Not Allowed)?
Closed October 19, 2022. Applications are no longer accepted; the program's newer notices are on this page when there are any.
How much funding is available?
Awards of up to $1.5 million each.
Who has been funded under RFA-CA-21-048?
NIH RePORTER lists 9 projects funded under RFA-CA-21-048 in fiscal 2022 to 2026, at 9 institutions. The most were at Sloan-Kettering Inst Can Research, Institute for Systems Biology, H. Lee Moffitt Cancer Ctr & Res Inst.
Who has won Cancer Biology Research grants before?
The largest recipients over five fiscal years were The Trustees of Columbia University in the City of New York, The Univeristy of Texas M.D. Anderson Cancer Center, Sloan-Kettering Institute for Cancer Research. The program made 3,142 awards worth $4.3 billion in that time.
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