RFA-AT-25-001: HEAL Initiative: Pain Research Enhancement Program (PREP) (R15 Clinical Trial Optional)
Closed
This grant is closed. A newer notice from the same program is open now: HEAL Initiative: Pain Research Enhancement Program (PREP) (R15 Clinical Trial Optional) (RFA-AT-25-003). Status: Closes November 23, 2026 (16 days left). It is in our archive of National Institutes of Health notices from 2024.
National Institutes of Health offered grants of up to $375,000 to colleges and universities. Applications closed on January 7, 2025.
From the official notice on Grants.gov, last changed January 8, 2025. Checked November 7, 2026.
- Award ceiling$375,000
- Cost sharingNot required
- Funding typeGrant
About this NIH notice
- Activity codeR15
- Clinical trialsOptional
- Funded byNCCIH
- Median yearly award$540,427
- Typical project length3 years
- R15, Research Enhancement Award. Small research projects at institutions that receive little NIH funding, with students taking part in the research. Other open R15 notices.
Projects funded under RFA-AT-25-001 were run by National Center for Complementary and Integrative Health (NCCIH, 1 project). Contact the program officer at the institute that fits your project before you apply; the notice lists them.
Application due dates, page limits and budget limits are set in the notice. Read RFA-AT-25-001 in the NIH Guide.
Other notices with this title
| Notice | Posted | Deadline | Status |
|---|---|---|---|
| RFA-AT-25-003 | January 8, 2025 | Closes November 23, 2026 (16 days left) | Open |
Key dates
| Posted | September 3, 2024 |
|---|---|
| Deadline | January 7, 2025 |
| Archived by Grants.gov | February 6, 2025 |
Who can apply
This opportunity was open to colleges and universities.
- Public and State controlled institutions of higher education
- Private institutions of higher education
- Others (see text field entitled "Additional Information on Eligibility" for clarification)
Other Eligible Applicants include the following: Alaska Native and Native Hawaiian Serving Institutions; Asian American Native American Pacific Islander Serving Institutions (AANAPISISs); Hispanic-serving Institutions; Historically Black Colleges and Universities (HBCUs); Tribally Controlled Colleges and Universities (TCCUs) ; See Funding Announcement for Eligibility criteriaNon-domestic (non-U.S.) Entities (Foreign Organizations) are not eligible to apply. Non-domestic (non-U.S.) components of U.S. Organizations are not eligible to apply. Foreign components, as defined in the NIH Grants Policy Statement, are allowed.
Is this a realistic fit?
- Projects NIH funded under this notice had a median yearly award of $540,427; it allows up to $375,000 per award.
- Most of the money in the 7 programs behind this notice (74% over five years) went to colleges and universities.
- No cost sharing or match is required.
What the grant funds
The purpose of this initiative is to: (1) support the efforts by R15-eligible Principal Investigators (PIs) to conduct rigorous basic and/or mechanistic pain research projects; (2) promote integrated, interdisciplinary research partnerships between R15-eligible PIs and additional investigators from U.S. domestic institutions, and (3) enhance the pain research environment at the R15-eligible institution for health professional trainees or undergraduate and/or graduate students by actively engaging them in the proposed pain research projects.
Funded under RFA-AT-25-001 so far
NIH funded 1 project under RFA-AT-25-001 in fiscal 2025, at 1 institution. The median yearly award was $540,427.
| Project | Institution | Fiscal year | Award |
|---|---|---|---|
| Modeling mechanisms of interindividual variation in pain modulation by spinal cord stimulation | Middlebury College | 2025 | $540,427 |
Who has won Aging Research grants before
From fiscal 2021 to 2025, Aging Research (93.866) awarded $19 billion across 11,026 grant awards, an average of $1.7 million per award.
| Recipient | State | Awards | Amount |
|---|---|---|---|
| The Regents of the University of California, San Francisco | California | 337 | $575 million |
| The Trustees of Columbia University in the City of New York | New York | 242 | $574 million |
| University of Southern California | California | 203 | $572 million |
| The Washington University | Missouri | 210 | $556 million |
| Regents of the University of Michigan | Michigan | 232 | $538 million |
Who has won Extramural Research Programs in the Neurosciences and Neurological Disorders grants before
From fiscal 2021 to 2025, Extramural Research Programs in the Neurosciences and Neurological Disorders (93.853) awarded $9.1 billion across 8,641 grant awards, an average of $1.0 million per award.
| Recipient | State | Awards | Amount |
|---|---|---|---|
| The General Hospital Corporation | Massachusetts | 203 | $288 million |
| The Regents of the University of California, San Francisco | California | 248 | $277 million |
| The Johns Hopkins University | Maryland | 230 | $276 million |
| The Trustees of Columbia University in the City of New York | New York | 188 | $226 million |
| Regents of the University of Michigan | Michigan | 179 | $221 million |
Who has won Child Health and Human Development Extramural Research grants before
From fiscal 2021 to 2025, Child Health and Human Development Extramural Research (93.865) awarded $6.0 billion across 6,026 grant awards, an average of $1.0 million per award.
| Recipient | State | Awards | Amount |
|---|---|---|---|
| Regents of the University of Michigan | Michigan | 167 | $178 million |
| The Johns Hopkins University | Maryland | 133 | $146 million |
| University of Washington | Washington | 114 | $131 million |
| Baylor College of Medicine | Texas | 116 | $124 million |
| The Leland Stanford Junior University | California | 104 | $116 million |
Other programs behind this notice
- Arthritis, Musculoskeletal and Skin Diseases Research
- Alcohol Research Programs
- Oral Diseases and Disorders Research
- Research and Training in Complementary and Integrative Health
Applying now
This notice no longer takes applications. Apply under the newer notice, RFA-AT-25-003, which is open now.
The notice on Grants.gov keeps its full text and attachments, which is useful for planning a resubmission.
Questions people ask
Is RFA-AT-25-001 still open?
No. It closed on January 7, 2025. A newer notice is open: RFA-AT-25-003, closes November 23, 2026 (16 days left).
Who can apply for HEAL Initiative: Pain Research Enhancement Program (PREP) (R15 Clinical Trial Optional)?
National Institutes of Health accepted applications from colleges and universities. The notice adds further conditions, so read its eligibility section.
What is the deadline for HEAL Initiative: Pain Research Enhancement Program (PREP) (R15 Clinical Trial Optional)?
Closed January 7, 2025. Applications are no longer accepted; the program's newer notices are on this page when there are any.
How much funding is available?
Awards of up to $375,000 each.
Who has been funded under RFA-AT-25-001?
NIH RePORTER lists 1 project funded under RFA-AT-25-001 in fiscal 2025, at 1 institution.
Who has won Oral Diseases and Disorders Research grants before?
The largest recipients over five fiscal years were Regents of the University of Michigan, The Regents of the University of California, San Francisco, University of Southern California. The program made 2,263 awards worth $1.9 billion in that time.
Similar open grants
- HEAL Initiative: Pain Research Enhancement Program (PREP) (R15 Clinical Trial Optional)
- Competing Revisions to Existing NIH Single Project Research Grants and Cooperative Agreements (Clinical Trial Optional)
- Academic Research Enhancement Award (AREA) for Undergraduate-Focused Institutions (R15 Clinical Trial Required)
- Change of Recipient Organization (Type 7 Parent Clinical Trial Optional)
- Research Enhancement Award Program (REAP) for Health Professional Schools and Graduate Schools (R15 Clinical Trial Required)
- Academic Research Enhancement Award (AREA) for Undergraduate-Focused Institutions (R15 Clinical Trial Required)