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PA-24-246: PHS 2024-2 Omnibus Solicitation of the NIH and CDC for Small Business Innovation Research Grant Applications (Parent SBIR [R43/R44] Clinical Trial Required)

Closed Closed September 5, 2025 Opportunity PA-24-246

This grant is closed. Who won this program's grants before is below, and similar open grants are at the end of the page. It is in our archive of National Institutes of Health notices from 2024.

National Institutes of Health offered grants to small businesses. Applications closed on September 5, 2025.

From the official notice on Grants.gov, last changed April 1, 2025. Checked November 7, 2026.

About this NIH notice

The title gives no activity code; these are the codes of the projects NIH funded under it.

Projects funded under PA-24-246 were run by National Cancer Institute (NCI, 30 projects), National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK, 14 projects), National Heart Lung and Blood Institute (NHLBI, 14 projects) and National Institute of Mental Health (NIMH, 10 projects), and 11 more. Contact the program officer at the institute that fits your project before you apply; the notice lists them.

Application due dates, page limits and budget limits are set in the notice. Read PA-24-246 in the NIH Guide.

Other notices with this title

National Institutes of Health has posted this title under other numbers: earlier or later rounds, or the same competition for another area. Each has its own dates and may change its rules.

NoticePostedDeadlineStatus
PA-23-231July 12, 2023Closed April 5, 2024Closed
PA-22-177June 2, 2022Closed April 5, 2023Closed
PA-21-260July 8, 2021Closed April 5, 2022Closed

Key dates

PostedJuly 3, 2024
DeadlineSeptember 5, 2025
Archived by Grants.govOctober 5, 2025

Who can apply

This opportunity was open to small businesses.

Other Eligible Applicants include the following:Non-domestic (non-U.S.) Entities (Foreign Organizations) are not eligible to apply. Non-domestic (non-U.S.) components of U.S. Organizations are not eligible to apply. Foreign components, as defined in the NIH Grants Policy Statement, may be allowed.

More grants for small businesses.

Is this a realistic fit?

What the grant funds

This Notice of Funding Opportunity Announcement (NOFO), issued by the National Institutes of Health (NIH) and the Centers for Disease Control and Prevention (CDC) invites eligible United States small businesses to submit Small Business Innovation Research (SBIR) grant applications. United States small businesses that have the research capabilities and technological expertise to contribute to the R and D mission(s) of the NIH and CDC awarding components identified in this NOFO are encouraged to submit SBIR grant applications in response to identified topics (see SBIR/STTR Program Descriptions and Research Topics for NIH, CDC, and FDA).This Parent Funding Opportunity Announcement requires that at least 1 clinical trial be proposed. The proposed project must be related to the programmatic interests of one or more of the participating NIH Institutes and Centers (ICs) based on their scientific missions.

Category: Education, Environment, Food and Nutrition, Health, Income Security and Social Services.

Funded under PA-24-246 so far

NIH funded 115 projects under PA-24-246 in fiscal 2025 to 2026, at 106 institutions. The median yearly award was $999,278.

Most projects: Million Marker Wellness Inc. (California), 3, KDH Research and Communication, Inc. (Georgia), 2, Vasoptic Medical, Inc. (Maryland), 2, Rise Therapeutics, LLC (Maryland), 2, UV01 Technologies, Inc (California), 2.

From NIH RePORTER, which lists each project once per fiscal year it was funded. Amounts are the yearly award.

Who has won Aging Research grants before

From fiscal 2021 to 2025, Aging Research (93.866) awarded $19 billion across 11,026 grant awards, an average of $1.7 million per award.

Largest recipients, fiscal 2021 to 2025
RecipientStateAwardsAmount
The Regents of the University of California, San FranciscoCalifornia337$575 million
The Trustees of Columbia University in the City of New YorkNew York242$574 million
University of Southern CaliforniaCalifornia203$572 million
The Washington UniversityMissouri210$556 million
Regents of the University of MichiganMichigan232$538 million

Top states: California ($3.4 billion), New York ($2.0 billion), Massachusetts ($1.8 billion), Pennsylvania ($1.0 billion), Texas ($912 million).

Who has won Cardiovascular Diseases Research grants before

From fiscal 2021 to 2025, Cardiovascular Diseases Research (93.837) awarded $15 billion across 11,798 grant awards, an average of $1.2 million per award.

Largest recipients, fiscal 2021 to 2025
RecipientStateAwardsAmount
The Trustees of the University of PennsylvaniaPennsylvania313$380 million
Brigham & Womens Hospital IncMassachusetts274$374 million
Regents of the University of MichiganMichigan277$355 million
The Trustees of Columbia University in the City of New YorkNew York207$335 million
University of Pittsburgh - of the Commonwealth System of Higher EducationPennsylvania295$320 million

Top states: California ($1.8 billion), Massachusetts ($1.5 billion), New York ($1.4 billion), Pennsylvania ($1.1 billion), Ohio ($749 million).

Who has won Diabetes, Digestive, and Kidney Diseases Extramural Research grants before

From fiscal 2021 to 2025, Diabetes, Digestive, and Kidney Diseases Extramural Research (93.847) awarded $9.6 billion across 7,877 grant awards, an average of $1.2 million per award.

Largest recipients, fiscal 2021 to 2025
RecipientStateAwardsAmount
Regents of the University of MichiganMichigan273$345 million
The Trustees of the University of PennsylvaniaPennsylvania187$272 million
University of Pittsburgh - of the Commonwealth System of Higher EducationPennsylvania209$238 million
The Washington UniversityMissouri187$227 million
The Regents of the University of California, San FranciscoCalifornia176$208 million

Top states: California ($1.2 billion), Massachusetts ($932 million), New York ($798 million), Pennsylvania ($762 million), Texas ($482 million).

Other programs behind this notice

Applying now

This notice no longer takes applications. Agencies often post the same opportunity again under a new number, so check the program's notices on Grants.gov and the similar open grants below.

The notice on Grants.gov keeps its full text and attachments, which is useful for planning a resubmission.

Questions people ask

Is PA-24-246 still open?

No. It closed on September 5, 2025.

Who can apply for PHS 2024-2 Omnibus Solicitation of the NIH and CDC for Small Business Innovation Research Grant Applications (Parent SBIR [R43/R44] Clinical Trial Required)?

National Institutes of Health accepted applications from small businesses. The notice adds further conditions, so read its eligibility section.

What is the deadline for PHS 2024-2 Omnibus Solicitation of the NIH and CDC for Small Business Innovation Research Grant Applications (Parent SBIR [R43/R44] Clinical Trial Required)?

Closed September 5, 2025. Applications are no longer accepted; the program's newer notices are on this page when there are any.

Who has been funded under PA-24-246?

NIH RePORTER lists 115 projects funded under PA-24-246 in fiscal 2025 to 2026, at 106 institutions. The most were at Million Marker Wellness Inc., KDH Research and Communication, Inc., Vasoptic Medical, Inc.

Who has won Environmental Health grants before?

The largest recipients over five fiscal years were Icahn School of Medicine at Mount Sinai, The Trustees of Columbia University in the City of New York, University of North Carolina at Chapel Hill. The program made 1,980 awards worth $2.1 billion in that time.

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