Grants for businesses in South Carolina
Federal agencies awarded $428 million in 57 grants to businesses in South Carolina from fiscal 2021 to 2025. The largest source was Manufacturing and Energy Supply Chain Demonstrations and Commercial Applications. 12 open or forecast federal grants are good fits for businesses.
- South Carolina ranks 30th of the 50 states and DC for federal grants to businesses.
- Grants to businesses made up 1% of all federal grant money to recipients in South Carolina.
- That is 1% of all federal grant money to businesses nationwide.
- Awarded, FY 2021 to 2025$428 million
- Grant awards57
- Good fits open nationwide12
Federal programs that fund businesses in South Carolina
| Program | Awarded to businesses in South Carolina |
|---|---|
| Manufacturing and Energy Supply Chain Demonstrations and Commercial Applications | $285 million |
| Education Stabilization Fund | $46.2 million |
| Teacher and School Leader Incentive Grants (formerly the Teacher Incentive Fund) | $21.3 million |
| Fossil Energy Research and Development | $17.4 million |
| Defense Production Act Title III (DPA Title III) | $13.8 million |
| Head Start | $7.1 million |
| Renewable Energy Research and Development | $5.7 million |
| Advanced Research Projects Agency - Energy | $4.3 million |
| Community Development Financial Institutions Rapid Response Program (CDFI RRP) | $3.7 million |
| GRRP | $3.4 million |
Businesses in South Carolina that received the most
| Recipient | Awards | Amount |
|---|---|---|
| Mercedes-Benz Vans, LLC | 1 | $285 million |
Open federal grants for businesses, best fits first
- Unlocking New Levels of Output and Capacity for Key Subsurface Resources (UNLOCK)
Open Closes November 20, 2026 (13 days left)
Businesses won 17% of the money in its program over five years - Advanced Nuclear Energy Licensing Cost-Share Grant Program
Open
Businesses won 55% of the money in its program over five years - Accelerating Scale-up and Pre-piloting of Emerging Chemical Technologies (ASPECT)
Open
Businesses won 28% of the money in its program over five years - Silcon Carbide Cladding Lead Test Rod Development-Phase 1
Open
Businesses won 55% of the money in its program over five years - National Bycatch Reduction Engineering Program (BREP) - FY2026/27
Open
Businesses won 22% of the money in its program over five years - Grid Supply Chain Alternatives to Lead Energy Dominance (SCALED)
Open
Businesses won 28% of the money in its program over five years - Department of Defense HIV/AIDS Prevention Program
Open
Businesses won 18% of the money in its program over five years - SEEDING CRITICAL ADVANCES FOR LEADING ENERGY TECHNOLOGIES WITH UNTAPPED POTENTIAL (SCALEUP) READY
Open
Businesses won 17% of the money in its program over five years - Geosciences Core Research: Atmospheric, Geospace, Earth and Ocean Sciences (GEO Core)
Open
Businesses won 12% of the money in its program over five years - Ocean Drilling Program
Open
Businesses won 12% of the money in its program over five years - RFI - DOE R
Open
Businesses won 55% of the money in its program over five years - Multilateral Partnerships Leveraging Excellence
Open
Businesses won 18% of the money in its program over five years - Cooperative Program for Modeling Clinical Transplantation
Forecast
Businesses won 0.1% of the money in its program over five years - HEAL Initiative: Program to Reveal and Evaluate Cells-to-gene Information that Specify Intricacies, Origins and the Nature of (PRECISION) Human Pain Network
Forecast
Businesses won less than 0.1% of the money in its program over five years - NIH Blueprint Initiative: Tools for Germline Gene Editing in the Nervous System
Forecast
Businesses won 0.4% of the money in its program over five years - BRAIN Initiative: Brain-Behavior Quantification and Synchronization – Transformative Research on Behavior at the Organismal Level
Forecast
Businesses won 1.6% of the money in its program over five years - Ancillary Studies to Ongoing Clinical Projects (RP1 Clinical Trial Not Allowed)
Forecast
Businesses won 0.2% of the money in the programs behind it over five years - Limited Competition: Small Grant Program for the NCATS Clinical and Translational Science Award (CTSA) Program (Clinical Trial Optional)
Forecast
Businesses won less than 0.1% of the money in its program over five years - Preservation and Reinvestment Initiative for Community Enhancement (PRICE)
Forecast
Businesses won 0% of the money in its program over five years - Impact of Immunotherapies on CNS Outcomes in People with HIV: Potential Benefits, Challenges and Risks
Forecast
Businesses won 0.1% of the money in its program over five years - HEAL Initiative: Optimization of Therapeutic Medical Devices through Team Science Mechanistic Research (RM1)
Forecast
Businesses won less than 0.1% of the money in its program over five years - The NIDDK Inflammatory Bowel Disease Genetics Consortium (IBDGC) Genomic Research Centers
Forecast
Businesses won less than 0.1% of the money in its program over five years - The NIDDK Inflammatory Bowel Disease Genetics Consortium (IBDGC) Data Coordinating Center
Forecast
Businesses won less than 0.1% of the money in its program over five years - The NIA Genetics of Alzheimer's Disease Data Storage Site (NIAGADS)
Forecast
Businesses won 0.2% of the money in its program over five years - Autism Centers of Excellence R01
Forecast
Businesses won 0.5% of the money in its program over five years
See all 747 open grants for businesses