Grants for businesses in Massachusetts
Federal agencies awarded $2.0 billion in 616 grants to businesses in Massachusetts from fiscal 2021 to 2025. The largest source was Geosciences. 770 federal grant opportunities are open or forecast now for businesses.
- Massachusetts ranks 5th of the 50 states and DC for federal grants to businesses.
- Grants to businesses made up 1% of all federal grant money to recipients in Massachusetts.
- That is 3% of all federal grant money to businesses nationwide.
- Awarded, FY 2021 to 2025$2.0 billion
- Grant awards616
- Open now nationwide770
Federal programs that fund businesses in Massachusetts
| Program | Awarded to businesses in Massachusetts |
|---|---|
| Geosciences | $317 million |
| Biomedical Advanced Research and Development Authority (BARDA), Biodefense Medical Countermeasure Development | $271 million |
| Manufacturing and Energy Supply Chain Demonstrations and Commercial Applications | $255 million |
| Clean Energy Demonstrations | $189 million |
| Clean School Bus Program | $140 million |
| Grid Infrastructure Deployment and Resilience | $100 million |
| STEM Education (formerly Education and Human Resources) | $72.8 million |
| USAID Foreign Assistance for Programs Overseas | $72.2 million |
| GRRP | $67.3 million |
| Education Stabilization Fund | $62.9 million |
Open federal grants businesses can apply for
- Exploratory Clinical Trial Grants in Arthritis and Musculoskeletal and Skin Diseases (R61 Clinical Trial Required)
Open Closes November 2, 2026 (2 days left) - Clinical Observational (CO) Studies in Musculoskeletal, Rheumatic, and Skin Diseases (R01 Clinical Trial Not Allowed)
Open Closes November 2, 2026 (2 days left) - BJA FY 2026 Comprehensive Opioid, Stimulant, and Substance Use Program (COSSUP) Training and Technical Assistance (TTA)
Open Closes November 2, 2026 (2 days left) - OJJDP FY 2026 Internet Crimes Against Children (ICAC) Task Force Program Support
Open Closes November 2, 2026 (2 days left) - Topology
Open Closes November 3, 2026 (3 days left) - Geometric Analysis
Open Closes November 3, 2026 (3 days left) - DoW Reconstructive Transplant, Concept Award
Open Closes November 4, 2026 (4 days left) - DoW Bone Marrow Failure, Idea Development Award
Open Closes November 4, 2026 (4 days left) - DoW Bone Marrow Failure, Investigator-Initiated Research Award
Open Closes November 4, 2026 (4 days left) - DoW Bone Marrow Failure, Resource Development Award
Open Closes November 4, 2026 (4 days left) - DoW Reconstructive Transplant, Investigator-Initiated Research Award
Open Closes November 4, 2026 (4 days left) - Exploring and Enhancing Outdoor and Heritage Tourism in the Chesapeake Bay Watershed
Open Closes November 4, 2026 (4 days left) - Developing novel theory and methods for understanding the genetic architecture of complex human traits (R01 Clinical Trial Not Allowed)
Open Closes November 5, 2026 (5 days left) - Emerging Infections Network - Research for Preventing, Detecting, and Managing Travel-associated Infectious Diseases
Open Closes November 5, 2026 (5 days left) - US Travelers Health Research, Surveillance, Communication, and Outreach Network
Open Closes November 5, 2026 (5 days left) - Request for Information - Gauging Investor Interest in the Development and Commercialization of Subsurface Energy Technologies
Open Closes November 5, 2026 (5 days left) - Secondary Analysis and Integration of Existing Data to Elucidate Cancer Risk and Related Outcomes (R01 Clinical Trial Not Allowed)
Open Closes November 6, 2026 (6 days left) - DoW Parkinson’s, Early Investigator Research Award
Open Closes November 6, 2026 (6 days left) - DoW Parkinson’s, Investigator-Initiated Research Award
Open Closes November 6, 2026 (6 days left) - Data Coordinating Center for the Aging and Alzheimer’s Disease Mouse Brain Atlas (AD-MBA) (U24 Clinical Trial Not Allowed)
Open Closes November 10, 2026 (10 days left) - Amyotrophic Lateral Sclerosis (ALS) Intermediate Patient Population Expanded Access (U01 Clinical Trial Required)
Open Closes November 10, 2026 (10 days left) - Advanced Development and Validation of Emerging Technologies for Basic and Clinical Cancer Research (R33 Clinical Trial Not Allowed)
Open Closes November 10, 2026 (10 days left) - Early-Stage Innovative Technology Development for Basic and Clinical Cancer Research (R61 Clinical Trial Not Allowed)
Open Closes November 10, 2026 (10 days left) - Infectious Diseases Clinical Trials Network (IDCTN) (UM1 Clinical Trial Required)
Open Closes November 10, 2026 (10 days left) - Clinical Research Network on Antimicrobial Resistance (UM1 Clinical Trial Required)
Open Closes November 10, 2026 (10 days left)
See all 770 open grants for businesses