Grants / Department of Health and Human Services / National Institutes of Health

Cooperative Program for Modeling Clinical Transplantation

Forecast Expected deadline October 9, 2026 Opportunity RFA-AI-27-017

• Award ceilingnot stated
• Award floornot stated
• Expected awards3
• Total funding$1.3 million
• Cost sharingNot required
• Funding typeCooperative Agreement

Key dates

Add the deadline to your calendar

Who can apply

This opportunity is open to nonprofits, colleges and universities, state and local governments, tribes, small businesses and businesses.

• State governments
• County governments
• City or township governments
• Special district governments
• Independent school districts
• Public and State controlled institutions of higher education
• Native American tribal governments (Federally recognized)
• Public housing authorities/Indian housing authorities
• Native American tribal organizations (other than Federally recognized tribal governments)
• Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education
• Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education
• Private institutions of higher education
• For profit organizations other than small businesses
• Small businesses
• Others (see text field entitled "Additional Information on Eligibility" for clarification)

Other Eligible ApplicantsIndian/Native American Tribal Governments (Other than Federally Recognized);Eligible Agencies of the Federal Government;U.S. Territory or Possession;Faith-based or Community-based Organizations;Regional Organizations

More grants for nonprofits, colleges and universities, state and local governments, tribes, small businesses, businesses.

Is this a realistic fit?

• No cost sharing or match is required.

What the grant funds

The National Institute of Allergy and Infectious Diseases (NIAID) will support its mission through the Cooperative Program for Modeling Clinical Transplantation. Advancements of new therapeutics and success in human solid organ transplantation will require innovative and clinically translatable in-vitro and in-vivo systems to model local and systemic immune responses. This program seeks applications including new approach methods (NAMs) and/or refined mouse models that together will promote translation of new therapies to clinical practice. Potential NAMs include immune-competent microphysiological systems, organoids, ex-vivo perfused human organs, precision-cut tissue slices, and computational systems biology models. Applicants must propose models designed to overcome known obstacles to clinical translation in existing NAMS and/or mouse models, reduce reliance on nonhuman primates, and demonstrate relevance to clinical outcomes. Emphasis on data sharing will facilitate reproducibility and establishment of standards and best practices to achieve the program goals. Grant authorities that allow NIAID to forecast this opportunity are as follows: Sections 301 and 405 of the Public Health Service Act as amended (42 USC 241 and 284) and under Federal Regulations 42 CFR Part 52 and 2 CFR Part 200.

Category: Health.

How to apply

1. Read the full notice and attachments on Grants.gov. The notice is the official source for deadlines and requirements.
2. Make sure your organization has an active SAM.gov registration and Unique Entity ID; registration can take several weeks.
3. Register on Grants.gov and submit through Workspace before the deadline and time given in the notice. Our application guide walks through each step.

Questions go to National Institute of Allergy and Infectious Diseases (NIAID), CPMCT_U01@mail.nih.gov, Please contact via e-mail..

Open the official notice