Federal grant programs / Department of Health and Human Services

Food and Drug Administration Research (93.103)

Also known as General Grant Funding

• Awarded, FY 2021 to 2025$1.2 billion
• Grant awards940
• Typical award$499,996
• Awarded in FY 2025$213 million
• Size rank236 of 1,823
• Type of assistanceCooperative agreements (discretionary grants), project grants (discretionary)

Key findings

• Annual funding rose from $203 million in fiscal 2021 to $213 million in fiscal 2025.
• It is the 236th largest of 1,823 federal grant programs by five-year awards.
• The 20 largest recipients received 44% of the money.
• Awards went to recipients in 51 states and territories.

What the program funds

To assist institutions and organizations, to establish, expand, and improve research, demonstration, education and information dissemination activities; acquired immunodeficiency syndrome (AIDS), biologics, blood and blood products, therapeutics, vaccines and allergenic projects; drug hazards, human and veterinary drugs, clinical trials on drugs and devices for orphan products development; nutrition, sanitation and microbiological hazards; medical devices and diagnostic products, radiation emitting devices and materials; food safety and food additives. These programs are supported directly or indirectly by the following Centers and Offices: Center for Biologics Evaluation and Research (CBER); Center for Drug Evaluation and Research (CDER); Center for Devices and Radiological Health (CDRH); Center for Veterinary Medicine (CVM), Center for Food Safety and Applied Nutrition (CFSAN), National Center for Toxicological Research (NCTR), the Office of Orphan Products Development (OPD), the Center for Tobacco Products (CTP), and Office of Regulatory Affairs (ORA), and the Office of the Commissioner (OC). Small Business Innovation Research (SBIR) Programs: to stimulate technological innovation; to encourage the role of small business to meet Federal research and development needs; to increase private sector commercialization of innovations derived from Federal research and development; and to foster and encourage participation by minority and disadvantaged persons in technological innovation. Funding support for scientific conferences that are relevant to the FDA scientific mission and public health are also available.

From the federal Assistance Listing. Read the full listing on SAM.gov.

Open and forecast opportunities

• Minor Use Minor Species Development of Drugs (R01)
  Open · Closes January 29, 2027 (83 days left) · up to $250,000
• Animal Food Regulatory Program Standards Implementation Development and Maintenance, with Mutual Reliance Initiatives Clinical Trials Not Allowed
  Open · Closes April 1, 2027 (145 days left) · up to $300,000
• NARMS Cooperative Agreement Program to Strengthen Antibiotic Resistance Surveillance in Retail Food Specimens
  Open · Closes April 1, 2027 (145 days left) · up to $200,000
• NIH, CDC and FDA Small Business Innovation Research Grant (Parent SBIR [R43/R44] Clinical Trial Optional)
  Open · Due dates in the notice, expires April 5, 2027
• Laboratory Flexible Funding Model (LFFM)
  Open · Closes January 11, 2028 (430 days left) · up to $1.5 million
• Reissue of RFA-FD-22-001 - Efficient and Innovative Natural History Studies Addressing Unmet Needs in Rare Diseases (R01 Clinical Trials Optional)
  Open · Closes February 8, 2028 (458 days left) · up to $600,000
• Animal and Veterinary Innovation Centers (U18)
  Open · Closes May 12, 2028 (552 days left) · up to $1.3 million
• Reissue of RFA-FD-23-001- Clinical Studies of Orphan Products Addressing Unmet Needs of Rare Diseases (R01 Clinical Trials Required)
  Open · Closes May 16, 2028 (556 days left) · up to $900,000
• Vet-LIRN Capacity-Building Project and Equipment Grants (U18)
  Open · Closes September 4, 2028 (667 days left) · up to $2.5 million
• Development and Maintenance of Human and Animal Food Rapid Response Teams
  Open · Rolling or no fixed deadline · up to $360,000
• National Produce Safety Partnership Program
  Open · Rolling or no fixed deadline · up to $12.0 million
• Flexible Funding Model - Advancing Domestic Mutual Reliance Through Strengthened Infrastructure Development and Maintenance for Manufactured Food Regulatory Programs
  Open · Rolling or no fixed deadline · up to $450,000
• African Medical Devices Regulatory Harmonization Program
  Forecast · Forecast, no dates yet
• Manufactured Foods Flexible Funding Model (MF-FFM)
  Forecast · Forecast, no dates yet
• Integrating Machine Learning with Computational Fluid Dynamics Models of Orally Inhaled Drug Products (U01) Clinical Trials Not Allowed
  Forecast · Forecast, no dates yet
• Developing PBPK Model-Based Mechanistic IVIVCs for Long Acting Injectable Suspensions and Implants (U01) Clinical Trial Optional
  Forecast · Forecast, no dates yet · up to $300,000
• Utilizing Real-World Data and Algorithmic Analyses to Assess Post-Market Clinical Outcomes in Patients Switching Amongst Therapeutically Equivalent Complex Generic Drug Products and Reference Listed Drugs (U01) Clinical Trial Not Allowed
  Forecast · Forecast, no dates yet · up to $300,000
• Evaluating the Cutaneous Pharmacokinetics of Topical Drug Products Using Pharmacokinetic Tomography (U01 Clinical Trial Required)
  Forecast · Forecast, no dates yet · up to $250,000
• Improving Predictability of Food-Drug and Drug-Drug Interaction Risks by Utilizing In Vitro Simulated Gastrointestinal Dissolution Model for High-Risk Oral Drug Products (U01) Clinical Trial Optional
  Forecast · Forecast, no dates yet · up to $500,000
• Identification of Drug-related and Formulation-Related Factors that Result in Alcohol Dose Dumping of Modified Release Oral Drug Products (U01) Clinical Trial Not Allowed
  Forecast · Forecast, no dates yet · up to $250,000
• Synthesis and Biological Activity Assessment of Different Diastereomers in siRNA Drug LEQVIO (Inclisiran) (U01) Clinical Trial Not Allowed
  Forecast · Forecast, no dates yet · up to $300,000
• Identification and Evaluation of Possible Approaches to Addressing Nitrosamine Impurities in Drugs (U01)
  Forecast · Forecast, no dates yet · up to $350,000
• Flexible Funding Model-Infrastructure Development and Maintenance for State Manufactured Food Regulatory Programs (U2F) Clinical Trials Not Allowed
  Forecast · Forecast, no dates yet · up to $1.3 million
• Cooperative Agreement to Support a Human Abuse Potential Study of Botanical Kratom (U01 Clinical Trial Required)
  Forecast · Forecast, no dates yet · up to $2.0 million
• Cooperative Agreement for Long Term Data Collection on Antimicrobial Use in Animals (U01) Clinical Trial Not Allowed
  Forecast · Forecast, no dates yet · up to $200,000

29 more opportunities are listed with all open grants from Department of Health and Human Services.

Rules from the program listing

Who can apply

Applicants should review the individual funding opportunity announcement issued under this CFDA program to see which applicant organizations are eligible to apply.

What the money can and cannot pay for

Research grants are awarded to eligible institutions in the name of a principal investigator for applications that are responsive to programmatic requirements as stated in the Funding Opportunity Announcement (FOA). Funds are to be used for costs as identified in the FOA and as directly allocable, necessary and reasonable to carry out the proposed research aims and objectives. Small Business Innovation Research (SBIR) Phase I grants are to establish the technical merit and feasibility of a proposed research effort that may lead to a commercial product or process. SBIR Phase II grants for this program are for the competitive continuation of the research initiated in Phase I, and are likely to result in commercial products or processes. Only Phase I awardees are eligible to apply for Phase II support. Conference grants provide partial support for domestic scientific conferences related to the FDA mission. Funding restrictions are noted in the Funding Opportunity Announcement and the Terms and Conditions of award.;

Matching requirements

This program has no statutory formula. Matching requirements are not applicable to this assistance listing. MOE requirements are not applicable to this assistance listing.

Deadlines

Applicants should review the individual Funding Opportunity Announcement (FOA) issued under this CFDA program to see the application deadline information.

Award range and average, in the agency's words

Varies by grant mechanism and program specific requirements.

Quoted from the program's federal Assistance Listing. The notice of funding opportunity is the official source for each competition's rules.

Who usually wins

Nonprofits received 35% of the money, colleges and universities 33% and state and local governments 25%.

By state

50 states have a page for this program: those that received at least $1 million or 10 awards.

Award amounts are federal obligations reported to USAspending.gov for fiscal 2021 to 2025; see how our data works.