RFA-HD-22-004: Developmental Mechanisms of Human Structural Birth Defects (P01 Clinical Trial Not Allowed)
Closed
This grant is closed. Who won this program's grants before is below, and similar open grants are at the end of the page. It is in our archive of National Institutes of Health notices from 2021.
National Institutes of Health offered grants of up to $1.0 million to nonprofits, colleges and universities, state and local governments, tribes, small businesses and businesses. It expected to make about 2 awards worth $3.0 million in total. Applications closed on July 29, 2021.
From the official notice on Grants.gov, last changed April 19, 2021. Checked November 7, 2026.
- Award ceiling$1.0 million
- Total funding$3.0 million
- Expected awards2
- Cost sharingNot required
- Funding typeGrant
About this NIH notice
- Activity codeP01
- Clinical trialsNot allowed
- Funded byNICHD
- Median yearly award$356,970
- Typical project length10.5 years
- P01, Research Program Project Grant. Several related research projects around one theme, with shared core facilities. Other open P01 notices.
Projects funded under RFA-HD-22-004 were run by Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD, 2 projects). Contact the program officer at the institute that fits your project before you apply; the notice lists them.
Application due dates, page limits and budget limits are set in the notice. Read RFA-HD-22-004 in the NIH Guide.
Key dates
| Posted | April 19, 2021 |
|---|---|
| Deadline | July 29, 2021 |
| Archived by Grants.gov | September 3, 2021 |
Who can apply
This opportunity was open to nonprofits, colleges and universities, state and local governments, tribes, small businesses and businesses.
All 15 applicant types the notice lists
- State governments
- County governments
- City or township governments
- Special district governments
- Independent school districts
- Public and State controlled institutions of higher education
- Native American tribal governments (Federally recognized)
- Public housing authorities/Indian housing authorities
- Native American tribal organizations (other than Federally recognized tribal governments)
- Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education
- Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education
- Private institutions of higher education
- For profit organizations other than small businesses
- Small businesses
- Others (see text field entitled "Additional Information on Eligibility" for clarification)
Other Eligible Applicants include the following: Alaska Native and Native Hawaiian Serving Institutions; Asian American Native American Pacific Islander Serving Institutions (AANAPISISs); Eligible Agencies of the Federal Government; Hispanic-serving Institutions; Historically Black Colleges and Universities (HBCUs); Indian/Native American Tribal Governments (Other than Federally Recognized); Regional Organizations; Tribally Controlled Colleges and Universities (TCCUs) ; U.S. Territory or Possession; Non-domestic (non-U.S.) Entities (Foreign Institutions) are not eligible to apply. Non-domestic (non-U.S.) components of U.S. Organizations are not eligible to apply. Foreign components, as defined in the NIH Grants Policy Statement, are allowed.
Is this a realistic fit?
- Projects NIH funded under this notice had a median yearly award of $356,970; it allows up to $1.0 million per award.
- Most of the program's money (72% over five years) went to colleges and universities.
- No cost sharing or match is required.
What the grant funds
The purpose of this funding opportunity announcement (FOA) is to support innovative, multidisciplinary, interactive, and synergistic program projects that integrate basic, translational, and clinical approaches to understanding the developmental biology and genetic basis of significant congenital human malformations. Each program project will consist of three component research projects, in addition to associated cores. At least one project must use basic research in an animal model system and at least one project must be clinical or translational in nature. The component research projects must share a common central theme, focus, or objective on a specific major developmental defect or malformation that is genotypically, mechanistically, biologically, or phenotypically analogous or homologous in both animal models and humans. Any non-mammalian or mammalian animal model may be used, as long as it contributes to the common overall theme or objective of the program project. The component research projects should share a common developmental gene, process, mechanism, pathway, or phenotype.
Funded under RFA-HD-22-004 so far
NIH funded 2 projects under RFA-HD-22-004 in fiscal 2022 to 2026, at 2 institutions. The median yearly award was $356,970.
| Project | Institution | Fiscal year | Award |
|---|---|---|---|
| Admin Core | Cincinnati Childrens Hosp Med Ctr | 2026 | $79,500 |
| Human Genetics and Clinical Translation | UT Southwestern Medical Center | 2026 | $321,459 |
Who has won Child Health and Human Development Extramural Research grants before
From fiscal 2021 to 2025, Child Health and Human Development Extramural Research (93.865) awarded $6.0 billion across 6,026 grant awards, an average of $1.0 million per award.
| Recipient | State | Awards | Amount |
|---|---|---|---|
| Regents of the University of Michigan | Michigan | 167 | $178 million |
| The Johns Hopkins University | Maryland | 133 | $146 million |
| University of Washington | Washington | 114 | $131 million |
| Baylor College of Medicine | Texas | 116 | $124 million |
| The Leland Stanford Junior University | California | 104 | $116 million |
Applying now
This notice no longer takes applications. Agencies often post the same opportunity again under a new number, so check the program's notices on Grants.gov and the similar open grants below.
The notice on Grants.gov keeps its full text and attachments, which is useful for planning a resubmission.
Questions people ask
Is RFA-HD-22-004 still open?
No. It closed on July 29, 2021.
Who can apply for Developmental Mechanisms of Human Structural Birth Defects (P01 Clinical Trial Not Allowed)?
National Institutes of Health accepted applications from nonprofits, colleges and universities, state and local governments, tribes, small businesses and businesses. The notice adds further conditions, so read its eligibility section.
What is the deadline for Developmental Mechanisms of Human Structural Birth Defects (P01 Clinical Trial Not Allowed)?
Closed July 29, 2021. Applications are no longer accepted; the program's newer notices are on this page when there are any.
How much funding is available?
Awards of up to $1.0 million each. About $3.0 million in total across about 2 awards.
Who has been funded under RFA-HD-22-004?
NIH RePORTER lists 2 projects funded under RFA-HD-22-004 in fiscal 2022 to 2026, at 2 institutions. The most were at Cincinnati Childrens Hosp Med Ctr, UT Southwestern Medical Center.
Who has won Child Health and Human Development Extramural Research grants before?
The largest recipients over five fiscal years were Regents of the University of Michigan, The Johns Hopkins University, University of Washington. The program made 6,026 awards worth $6.0 billion in that time.
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