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Grants / Department of Health and Human Services / National Institutes of Health

NIAID Investigator Initiated Program Project Applications (P01 Clinical Trial Not Allowed)

Open Closes May 25, 2029 (937 days left) Opportunity PAR-27-082

National Institutes of Health is offering grants to nonprofits, colleges and universities, state and local governments, tribes, small businesses and businesses. Applications close on May 25, 2029.

From the official notice on Grants.gov, last changed May 7, 2026. Checked October 31, 2026.

Key dates

PostedMay 7, 2026
DeadlineMay 25, 2029
Archived by Grants.govJuly 24, 2029

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Who can apply

This opportunity is open to nonprofits, colleges and universities, state and local governments, tribes, small businesses and businesses.

Refer to Section III. Eligibility Information in the NOFO for additional information on eligibility. Foreign Organizations/International Collaborations:Non-domestic (non-U.S.) Entities (Foreign Organization) are not eligible to apply. Non-domestic (non-U.S.) components of U.S. Organizations are not eligible to apply. Foreign components, as defined in the NIH Grants Policy Statement, are allowed.

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Is this a realistic fit?

What the grant funds

This notice of funding opportunity (NOFO) invites submission of investigator-initiated Program Project (P01) applications. The proposed Programs should address scientific areas relevant to the NIAID mission including: biology and pathogenesis of infectious microbes, including HIV; host-microbe interactions; mechanisms regulating immune system development and function across the lifespan, and in response to infectious pathogens; immune dysfunction resulting in allergy, asthma, autoimmunity, immunodeficiency, or transplant rejection; and translational research to develop vaccines, therapeutics, and diagnostics to prevent and treat infectious and immune-mediated diseases. Each application submitted to this NOFO must include at least two related, synergistic Research Projects that share a common central theme, focus, and/or overall objective; and an Administrative Core. An application may include Scientific Core(s), if needed for the proposed research.

Category: Health.

How to apply

  1. Read the full notice and attachments on Grants.gov. The notice is the official source for deadlines and requirements.
  2. Make sure your organization has an active SAM.gov registration and Unique Entity ID; registration can take several weeks.
  3. Register on Grants.gov and submit through Workspace before the deadline and time given in the notice. Our application guide walks through each step.

Questions go to National Institutes of Health, NIAID_P01_NOFO@mail.nih.gov, 301-402-2541.

Open the official notice

Questions people ask

Who can apply for NIAID Investigator Initiated Program Project Applications (P01 Clinical Trial Not Allowed)?

National Institutes of Health accepts applications from nonprofits, colleges and universities, state and local governments, tribes, small businesses and businesses. The notice adds further conditions, so read its eligibility section.

What is the deadline for NIAID Investigator Initiated Program Project Applications (P01 Clinical Trial Not Allowed)?

Closes May 25, 2029 (937 days left). Confirm the date and time in the official notice on Grants.gov.

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