RFA-DA-21-030: HEAL Initiative: Integrative Management of chronic Pain and OUD for Whole Recovery (IMPOWR): Research Centers (RM1 Clinical Trial Required)
Closed
This grant is closed. A newer notice from the same program is open now: HEAL Initiative: Integrative Management of Chronic Pain and OUD for Whole Recovery (IMPOWR): Research Centers (RM1 Clinical Trial Required) (RFA-DA-28-011). Status: Closes January 26, 2027 (80 days left). It is in our archive of National Institutes of Health notices from 2021.
National Institutes of Health offered grants of up to $1.8 million to nonprofits, colleges and universities, state and local governments, tribes, small businesses and businesses. It expected to make $7.3 million in total. Applications closed on March 26, 2021.
From the official notice on Grants.gov, last changed January 12, 2021. Checked November 7, 2026.
- Award ceiling$1.8 million
- Total funding$7.3 million
- Cost sharingNot required
- Funding typeGrant
About this NIH notice
- Activity codeRM1
- Clinical trialsRequired
- Funded byNIDA
- Median yearly award$2.4 million
- Typical project length6 years
- RM1, Research Project with Complex Structure. A large research project with several connected parts under one award. Other open RM1 notices.
Projects funded under RFA-DA-21-030 were run by National Institute on Drug Abuse (NIDA, 4 projects). Contact the program officer at the institute that fits your project before you apply; the notice lists them.
Application due dates, page limits and budget limits are set in the notice. Read RFA-DA-21-030 in the NIH Guide.
Other notices with this title
| Notice | Posted | Deadline | Status |
|---|---|---|---|
| RFA-DA-28-011 | October 6, 2026 | Closes January 26, 2027 (80 days left) | Open |
Key dates
| Posted | January 11, 2021 |
|---|---|
| Deadline | March 26, 2021 |
| Archived by Grants.gov | April 25, 2021 |
Who can apply
This opportunity was open to nonprofits, colleges and universities, state and local governments, tribes, small businesses and businesses.
All 15 applicant types the notice lists
- State governments
- County governments
- City or township governments
- Special district governments
- Independent school districts
- Public and State controlled institutions of higher education
- Native American tribal governments (Federally recognized)
- Public housing authorities/Indian housing authorities
- Native American tribal organizations (other than Federally recognized tribal governments)
- Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education
- Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education
- Private institutions of higher education
- For profit organizations other than small businesses
- Small businesses
- Others (see text field entitled "Additional Information on Eligibility" for clarification)
Other Eligible Applicants include the following: Alaska Native and Native Hawaiian Serving Institutions; Asian American Native American Pacific Islander Serving Institutions (AANAPISISs); Eligible Agencies of the Federal Government; Faith-based or Community-based Organizations; Hispanic-serving Institutions; Historically Black Colleges and Universities (HBCUs); Indian/Native American Tribal Governments (Other than Federally Recognized); Regional Organizations; Tribally Controlled Colleges and Universities (TCCUs) ; U.S. Territory or Possession; Non-domestic (non-U.S.) Entities (Foreign Institutions) are not eligible to apply. Non-domestic (non-U.S.) components of U.S. Organizations are not eligible to apply. Foreign components, as defined in the NIH Grants Policy Statement, are not allowed.
Is this a realistic fit?
- Projects NIH funded under this notice had a median yearly award of $2.4 million; it allows up to $1.8 million per award.
- Most of the money in the 5 programs behind this notice (70% over five years) went to colleges and universities.
- No cost sharing or match is required.
What the grant funds
enter purposeChronic Non-Cancer Pain (CP) and Opioid Use Disorder (OUD) overlap significantly and patients with both conditions present particular clinical complexity. CP adversely impacts OUD treatment adherence and recovery, while the presence of dependence stigmatizes treatment services for chronic pain, often resulting in insufficient pain treatment. Fundamentally, the healthcare system lacks the expertise and effective interventions for managing comorbid CP and OUD, leaving patients suffering and at risk for poor outcomes. The National Institutes of Health (NIH) intends to establish a national network consisting of investigators conducting Collaborative research on Co-managing Chronic Pain and Opioid Use Disorder (C3PO), which will be supported by a Resource on Related DSM-5 Diagnoses (R2D2) Coordination and Dissemination center. This network is intended to facilitate multidisciplinary team science collaborations that can create actionable, translatable, and sustainable treatments to improve the capacity of the health care system to effectively respond to the opioid epidemic. The network will be part of the NIHs Helping to End Addiction Long-term (HEAL)SM Initiative to speed the development and implementation of scientific solutions to the national opioid public health crisis. The NIH HEAL Initiative will bolster research across NIH to (1) improve treatment and prevention of opioid misuse and opioid use disorder and (2) enhance pain management.
Funded under RFA-DA-21-030 so far
NIH funded 4 projects under RFA-DA-21-030 in fiscal 2021 to 2025, at 4 institutions. The median yearly award was $2.4 million.
| Project | Institution | Fiscal year | Award |
|---|---|---|---|
| Integrated Care for Chronic Pain and Opioid Use Disorder: The IMPOWR Research Center at Montefiore/Einstein (IMPOWR-ME) | Albert Einstein College of Medicine | 2025 | $2.5 million |
| Tailored Retention and Engagement for Effective integrated Treatment of OUD and Pain (TREETOP) | University of Pittsburgh at Pittsburgh | 2025 | $2.4 million |
| HEAL Initiative: Integrative Management of chronic Pain and OUD for Whole Recovery (IMPOWR): Research Centers | Yale University | 2025 | $2.3 million |
| Integrative Treatment for Achieving Holistic Recovery from Comorbid Chronic Pain and Opioid Use Disorder | University of New Mexico | 2025 | $2.0 million |
Who has won Mental Health Research Grants grants before
From fiscal 2021 to 2025, Mental Health Research Grants (93.242) awarded $8.8 billion across 6,785 grant awards, an average of $1.3 million per award.
| Recipient | State | Awards | Amount |
|---|---|---|---|
| Yale Univ | Connecticut | 185 | $371 million |
| University of Pittsburgh - of the Commonwealth System of Higher Education | Pennsylvania | 200 | $297 million |
| University of California, Los Angeles | California | 176 | $234 million |
| Icahn School of Medicine at Mount Sinai | New York | 144 | $212 million |
| The Washington University | Missouri | 149 | $211 million |
Who has won Drug Use and Addiction Research Programs grants before
From fiscal 2021 to 2025, Drug Use and Addiction Research Programs (93.279) awarded $7.3 billion across 5,071 grant awards, an average of $1.4 million per award.
| Recipient | State | Awards | Amount |
|---|---|---|---|
| Yale Univ | Connecticut | 150 | $305 million |
| The Johns Hopkins University | Maryland | 156 | $262 million |
| University of California, San Diego | California | 120 | $242 million |
| University of Pittsburgh - of the Commonwealth System of Higher Education | Pennsylvania | 100 | $182 million |
| New York University | New York | 62 | $173 million |
Who has won Arthritis, Musculoskeletal and Skin Diseases Research grants before
From fiscal 2021 to 2025, Arthritis, Musculoskeletal and Skin Diseases Research (93.846) awarded $2.6 billion across 2,897 grant awards, an average of $908,766 per award.
| Recipient | State | Awards | Amount |
|---|---|---|---|
| The Trustees of the University of Pennsylvania | Pennsylvania | 104 | $104 million |
| Brigham & Womens Hospital Inc | Massachusetts | 89 | $95.7 million |
| The Regents of the University of California, San Francisco | California | 84 | $93.3 million |
| The Washington University | Missouri | 88 | $72.4 million |
| Regents of the University of Michigan | Michigan | 73 | $68.0 million |
Other programs behind this notice
Applying now
This notice no longer takes applications. Apply under the newer notice, RFA-DA-28-011, which is open now.
The notice on Grants.gov keeps its full text and attachments, which is useful for planning a resubmission.
Questions people ask
Is RFA-DA-21-030 still open?
No. It closed on March 26, 2021. A newer notice is open: RFA-DA-28-011, closes January 26, 2027 (80 days left).
Who can apply for HEAL Initiative: Integrative Management of chronic Pain and OUD for Whole Recovery (IMPOWR): Research Centers (RM1 Clinical Trial Required)?
National Institutes of Health accepted applications from nonprofits, colleges and universities, state and local governments, tribes, small businesses and businesses. The notice adds further conditions, so read its eligibility section.
What is the deadline for HEAL Initiative: Integrative Management of chronic Pain and OUD for Whole Recovery (IMPOWR): Research Centers (RM1 Clinical Trial Required)?
Closed March 26, 2021. Applications are no longer accepted; the program's newer notices are on this page when there are any.
How much funding is available?
Awards of up to $1.8 million each. About $7.3 million in total.
Who has been funded under RFA-DA-21-030?
NIH RePORTER lists 4 projects funded under RFA-DA-21-030 in fiscal 2021 to 2025, at 4 institutions. The most were at Albert Einstein College of Medicine, University of Pittsburgh at Pittsburgh, Yale University.
Who has won Research and Training in Complementary and Integrative Health grants before?
The largest recipients over five fiscal years were Yale Univ, The General Hospital Corporation, Duke University. The program made 653 awards worth $575 million in that time.
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