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Grants / Department of Health and Human Services / National Institutes of Health

RFA-CA-22-045: NCI Outstanding Investigator Award (R35 Clinical Trial Optional)

Closed Closed November 7, 2024 Opportunity RFA-CA-22-045

This grant is closed. Who won this program's grants before is below, and similar open grants are at the end of the page. It is in our archive of National Institutes of Health notices from 2022.

National Institutes of Health offered grants of up to $600,000 to nonprofits, colleges and universities, state and local governments, tribes, small businesses and businesses. Applications closed on November 7, 2024.

From the official notice on Grants.gov, last changed July 26, 2022. Checked November 7, 2026.

About this NIH notice

Projects funded under RFA-CA-22-045 were run by National Cancer Institute (NCI, 42 projects). Contact the program officer at the institute that fits your project before you apply; the notice lists them.

Application due dates, page limits and budget limits are set in the notice. Read RFA-CA-22-045 in the NIH Guide.

Key dates

PostedJuly 26, 2022
DeadlineNovember 7, 2024
Archived by Grants.govDecember 13, 2024

Who can apply

This opportunity was open to nonprofits, colleges and universities, state and local governments, tribes, small businesses and businesses.

All 15 applicant types the notice lists

Other Eligible Applicants include the following: Alaska Native and Native Hawaiian Serving Institutions; Asian American Native American Pacific Islander Serving Institutions (AANAPISISs); Eligible Agencies of the Federal Government; Faith-based or Community-based Organizations; Hispanic-serving Institutions; Historically Black Colleges and Universities (HBCUs); Indian/Native American Tribal Governments (Other than Federally Recognized); Non-domestic (non-U.S.) Entities (Foreign Organizations); Regional Organizations; Tribally Controlled Colleges and Universities (TCCUs) ; U.S. Territory or Possession; Non-domestic (non-U.S.) Entities (Foreign Institutions) are not eligible to apply. Non-domestic (non-U.S.) components of U.S. Organizations are not eligible to apply. Foreign components, as defined in the NIH Grants Policy Statement, are allowed.

More grants for nonprofits, colleges and universities, state and local governments, tribes, small businesses, businesses.

Is this a realistic fit?

What the grant funds

This Funding Opportunity Announcement (FOA) invites grant applications for the Outstanding Investigator Award (R35) in any area of cancer research. The objective of the National Cancer Institute (NCI) Outstanding Investigator Award (OIA) is to provide long-term support to accomplished investigators with outstanding records of cancer research productivity who propose to conduct exceptional research. The OIA is intended to allow investigators the opportunity to take greater risks, be more adventurous in their lines of inquiry, or take the time to develop new techniques. The OIA would allow an Institution to submit applications nominating established Program Directors/Principal Investigators (PDs/PIs) for the NCI OIA.It is expected that the OIA would provide extended funding stability and encourage investigators to embark on projects of unusual potential in cancer research. The research projects should break new ground or extend previous discoveries toward new directions or applications that may lead to a breakthrough that will advance biomedical, behavioral, or clinical cancer research.

Category: Education, Health.

Funded under RFA-CA-22-045 so far

NIH funded 42 projects under RFA-CA-22-045 in fiscal 2023 to 2026, at 30 institutions. The median yearly award was $975,148.

Most projects: Dana-Farber Cancer Inst (Massachusetts), 6, Sloan-Kettering Inst Can Research (New York), 4, Beckman Research Institute/City of Hope (California), 2, Columbia University Health Sciences (New York), 2, UT Southwestern Medical Center (Texas), 2.

Recently funded projects
ProjectInstitutionFiscal yearAward
Targeting Glioblastoma Stem Cells R35Univ of North Carolina Chapel Hill2026$918,524
Targeting DNA Repair for Cancer Therapy. R35Yale University2026$1.0 million
Integrating targeted therapy and immunotherapy to break through cancer R35Dana-Farber Cancer Inst2026$1.0 million
Understanding and Targeting Aberrant RNA Splicing in Leukemia R35Sloan-Kettering Inst Can Research2026$1.0 million
Defining Drivers of HPV-associated Carcinogenesis R35University of Wisconsin-Madison2026$930,851
Human natural killer cells: Advancing biology and clinical applications R35Beckman Research Institute/City of Hope2026$886,438
Overcoming Resistance to Targeted Therapy in Breast Cancer R35Sloan-Kettering Inst Can Research2026$1.1 million
Mesoscale and Nanoscale Technologies Integrated by Structures for DNA Repair Complexes (MANTIS-DRC) R35University of TX MD Anderson Can Ctr2026$814,230

From NIH RePORTER, which lists each project once per fiscal year it was funded. Amounts are the yearly award.

Who has won Cancer Treatment Research grants before

From fiscal 2021 to 2025, Cancer Treatment Research (93.395) awarded $5.6 billion across 3,622 grant awards, an average of $1.5 million per award.

Largest recipients, fiscal 2021 to 2025
RecipientStateAwardsAmount
The Univeristy of Texas M.D. Anderson Cancer CenterTexas144$188 million
Dana-Farber Cancer Institute, Inc.Massachusetts68$185 million
Icahn School of Medicine at Mount SinaiNew York35$179 million
Public Health InstituteCalifornia4$168 million
Fred Hutchinson Cancer CenterWashington57$156 million

Top states: California ($843 million), New York ($604 million), Massachusetts ($568 million), Texas ($444 million), Pennsylvania ($417 million).

Who has won Cancer Biology Research grants before

From fiscal 2021 to 2025, Cancer Biology Research (93.396) awarded $4.3 billion across 3,142 grant awards, an average of $1.4 million per award.

Largest recipients, fiscal 2021 to 2025
RecipientStateAwardsAmount
The Trustees of Columbia University in the City of New YorkNew York70$151 million
The Univeristy of Texas M.D. Anderson Cancer CenterTexas109$144 million
Sloan-Kettering Institute for Cancer ResearchNew York66$136 million
Dana-Farber Cancer Institute, Inc.Massachusetts47$107 million
The Regents of the University of California, San FranciscoCalifornia64$95.5 million

Top states: New York ($712 million), California ($608 million), Massachusetts ($409 million), Texas ($373 million), Pennsylvania ($286 million).

Who has won Cancer Cause and Prevention Research grants before

From fiscal 2021 to 2025, Cancer Cause and Prevention Research (93.393) awarded $3.6 billion across 2,517 grant awards, an average of $1.4 million per award.

Largest recipients, fiscal 2021 to 2025
RecipientStateAwardsAmount
The Univeristy of Texas M.D. Anderson Cancer CenterTexas81$107 million
Sloan-Kettering Institute for Cancer ResearchNew York65$99.1 million
The Trustees of Columbia University in the City of New YorkNew York48$85.3 million
Dana-Farber Cancer Institute, Inc.Massachusetts51$83.1 million
University of North Carolina at Chapel HillNorth Carolina49$76.1 million

Top states: California ($465 million), New York ($445 million), Massachusetts ($350 million), Texas ($259 million), Pennsylvania ($175 million).

Other programs behind this notice

Applying now

This notice no longer takes applications. Agencies often post the same opportunity again under a new number, so check the program's notices on Grants.gov and the similar open grants below.

The notice on Grants.gov keeps its full text and attachments, which is useful for planning a resubmission.

Questions people ask

Is RFA-CA-22-045 still open?

No. It closed on November 7, 2024.

Who can apply for NCI Outstanding Investigator Award (R35 Clinical Trial Optional)?

National Institutes of Health accepted applications from nonprofits, colleges and universities, state and local governments, tribes, small businesses and businesses. The notice adds further conditions, so read its eligibility section.

What is the deadline for NCI Outstanding Investigator Award (R35 Clinical Trial Optional)?

Closed November 7, 2024. Applications are no longer accepted; the program's newer notices are on this page when there are any.

How much funding is available?

Awards of up to $600,000 each.

Who has been funded under RFA-CA-22-045?

NIH RePORTER lists 42 projects funded under RFA-CA-22-045 in fiscal 2023 to 2026, at 30 institutions. The most were at Dana-Farber Cancer Inst, Sloan-Kettering Inst Can Research, Beckman Research Institute/City of Hope.

Who has won Cancer Cause and Prevention Research grants before?

The largest recipients over five fiscal years were The Univeristy of Texas M.D. Anderson Cancer Center, Sloan-Kettering Institute for Cancer Research, The Trustees of Columbia University in the City of New York. The program made 2,517 awards worth $3.6 billion in that time.

Similar open grants