RFA-CA-22-045: NCI Outstanding Investigator Award (R35 Clinical Trial Optional)
Closed
This grant is closed. Who won this program's grants before is below, and similar open grants are at the end of the page. It is in our archive of National Institutes of Health notices from 2022.
National Institutes of Health offered grants of up to $600,000 to nonprofits, colleges and universities, state and local governments, tribes, small businesses and businesses. Applications closed on November 7, 2024.
From the official notice on Grants.gov, last changed July 26, 2022. Checked November 7, 2026.
- Award ceiling$600,000
- Cost sharingNot required
- Funding typeGrant
About this NIH notice
- Activity codeR35
- Clinical trialsOptional
- Funded byNCI
- Median yearly award$975,148
- Typical project length13 years
- R35, Outstanding Investigator Award. Support for an investigator's whole research program rather than a single project (this includes MIRA awards). Other open R35 notices.
Projects funded under RFA-CA-22-045 were run by National Cancer Institute (NCI, 42 projects). Contact the program officer at the institute that fits your project before you apply; the notice lists them.
Application due dates, page limits and budget limits are set in the notice. Read RFA-CA-22-045 in the NIH Guide.
Key dates
| Posted | July 26, 2022 |
|---|---|
| Deadline | November 7, 2024 |
| Archived by Grants.gov | December 13, 2024 |
Who can apply
This opportunity was open to nonprofits, colleges and universities, state and local governments, tribes, small businesses and businesses.
All 15 applicant types the notice lists
- State governments
- County governments
- City or township governments
- Special district governments
- Independent school districts
- Public and State controlled institutions of higher education
- Native American tribal governments (Federally recognized)
- Public housing authorities/Indian housing authorities
- Native American tribal organizations (other than Federally recognized tribal governments)
- Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education
- Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education
- Private institutions of higher education
- For profit organizations other than small businesses
- Small businesses
- Others (see text field entitled "Additional Information on Eligibility" for clarification)
Other Eligible Applicants include the following: Alaska Native and Native Hawaiian Serving Institutions; Asian American Native American Pacific Islander Serving Institutions (AANAPISISs); Eligible Agencies of the Federal Government; Faith-based or Community-based Organizations; Hispanic-serving Institutions; Historically Black Colleges and Universities (HBCUs); Indian/Native American Tribal Governments (Other than Federally Recognized); Non-domestic (non-U.S.) Entities (Foreign Organizations); Regional Organizations; Tribally Controlled Colleges and Universities (TCCUs) ; U.S. Territory or Possession; Non-domestic (non-U.S.) Entities (Foreign Institutions) are not eligible to apply. Non-domestic (non-U.S.) components of U.S. Organizations are not eligible to apply. Foreign components, as defined in the NIH Grants Policy Statement, are allowed.
Is this a realistic fit?
- Projects NIH funded under this notice had a median yearly award of $975,148; it allows up to $600,000 per award.
- Most of the money in the 7 programs behind this notice (63% over five years) went to colleges and universities.
- No cost sharing or match is required.
What the grant funds
This Funding Opportunity Announcement (FOA) invites grant applications for the Outstanding Investigator Award (R35) in any area of cancer research. The objective of the National Cancer Institute (NCI) Outstanding Investigator Award (OIA) is to provide long-term support to accomplished investigators with outstanding records of cancer research productivity who propose to conduct exceptional research. The OIA is intended to allow investigators the opportunity to take greater risks, be more adventurous in their lines of inquiry, or take the time to develop new techniques. The OIA would allow an Institution to submit applications nominating established Program Directors/Principal Investigators (PDs/PIs) for the NCI OIA.It is expected that the OIA would provide extended funding stability and encourage investigators to embark on projects of unusual potential in cancer research. The research projects should break new ground or extend previous discoveries toward new directions or applications that may lead to a breakthrough that will advance biomedical, behavioral, or clinical cancer research.
Funded under RFA-CA-22-045 so far
NIH funded 42 projects under RFA-CA-22-045 in fiscal 2023 to 2026, at 30 institutions. The median yearly award was $975,148.
| Project | Institution | Fiscal year | Award |
|---|---|---|---|
| Targeting Glioblastoma Stem Cells | Univ of North Carolina Chapel Hill | 2026 | $918,524 |
| Targeting DNA Repair for Cancer Therapy. | Yale University | 2026 | $1.0 million |
| Integrating targeted therapy and immunotherapy to break through cancer | Dana-Farber Cancer Inst | 2026 | $1.0 million |
| Understanding and Targeting Aberrant RNA Splicing in Leukemia | Sloan-Kettering Inst Can Research | 2026 | $1.0 million |
| Defining Drivers of HPV-associated Carcinogenesis | University of Wisconsin-Madison | 2026 | $930,851 |
| Human natural killer cells: Advancing biology and clinical applications | Beckman Research Institute/City of Hope | 2026 | $886,438 |
| Overcoming Resistance to Targeted Therapy in Breast Cancer | Sloan-Kettering Inst Can Research | 2026 | $1.1 million |
| Mesoscale and Nanoscale Technologies Integrated by Structures for DNA Repair Complexes (MANTIS-DRC) | University of TX MD Anderson Can Ctr | 2026 | $814,230 |
Who has won Cancer Treatment Research grants before
From fiscal 2021 to 2025, Cancer Treatment Research (93.395) awarded $5.6 billion across 3,622 grant awards, an average of $1.5 million per award.
| Recipient | State | Awards | Amount |
|---|---|---|---|
| The Univeristy of Texas M.D. Anderson Cancer Center | Texas | 144 | $188 million |
| Dana-Farber Cancer Institute, Inc. | Massachusetts | 68 | $185 million |
| Icahn School of Medicine at Mount Sinai | New York | 35 | $179 million |
| Public Health Institute | California | 4 | $168 million |
| Fred Hutchinson Cancer Center | Washington | 57 | $156 million |
Who has won Cancer Biology Research grants before
From fiscal 2021 to 2025, Cancer Biology Research (93.396) awarded $4.3 billion across 3,142 grant awards, an average of $1.4 million per award.
| Recipient | State | Awards | Amount |
|---|---|---|---|
| The Trustees of Columbia University in the City of New York | New York | 70 | $151 million |
| The Univeristy of Texas M.D. Anderson Cancer Center | Texas | 109 | $144 million |
| Sloan-Kettering Institute for Cancer Research | New York | 66 | $136 million |
| Dana-Farber Cancer Institute, Inc. | Massachusetts | 47 | $107 million |
| The Regents of the University of California, San Francisco | California | 64 | $95.5 million |
Who has won Cancer Cause and Prevention Research grants before
From fiscal 2021 to 2025, Cancer Cause and Prevention Research (93.393) awarded $3.6 billion across 2,517 grant awards, an average of $1.4 million per award.
| Recipient | State | Awards | Amount |
|---|---|---|---|
| The Univeristy of Texas M.D. Anderson Cancer Center | Texas | 81 | $107 million |
| Sloan-Kettering Institute for Cancer Research | New York | 65 | $99.1 million |
| The Trustees of Columbia University in the City of New York | New York | 48 | $85.3 million |
| Dana-Farber Cancer Institute, Inc. | Massachusetts | 51 | $83.1 million |
| University of North Carolina at Chapel Hill | North Carolina | 49 | $76.1 million |
Other programs behind this notice
- Cancer Centers Support Grants
- Cancer Detection and Diagnosis Research
- Cancer Research Manpower
- Cancer Control
Applying now
This notice no longer takes applications. Agencies often post the same opportunity again under a new number, so check the program's notices on Grants.gov and the similar open grants below.
The notice on Grants.gov keeps its full text and attachments, which is useful for planning a resubmission.
Questions people ask
Is RFA-CA-22-045 still open?
No. It closed on November 7, 2024.
Who can apply for NCI Outstanding Investigator Award (R35 Clinical Trial Optional)?
National Institutes of Health accepted applications from nonprofits, colleges and universities, state and local governments, tribes, small businesses and businesses. The notice adds further conditions, so read its eligibility section.
What is the deadline for NCI Outstanding Investigator Award (R35 Clinical Trial Optional)?
Closed November 7, 2024. Applications are no longer accepted; the program's newer notices are on this page when there are any.
How much funding is available?
Awards of up to $600,000 each.
Who has been funded under RFA-CA-22-045?
NIH RePORTER lists 42 projects funded under RFA-CA-22-045 in fiscal 2023 to 2026, at 30 institutions. The most were at Dana-Farber Cancer Inst, Sloan-Kettering Inst Can Research, Beckman Research Institute/City of Hope.
Who has won Cancer Cause and Prevention Research grants before?
The largest recipients over five fiscal years were The Univeristy of Texas M.D. Anderson Cancer Center, Sloan-Kettering Institute for Cancer Research, The Trustees of Columbia University in the City of New York. The program made 2,517 awards worth $3.6 billion in that time.
Similar open grants
- NHLBI Outstanding Investigator Award (OIA) (R35 Clinical Trial Optional)
- NHLBI Emerging Investigator Award (EIA) (R35 Clinical Trial Optional)
- Change of Recipient Organization (Type 7 Parent Clinical Trial Optional)
- Investigator-Focused Award (Parent R35)
- Maximizing Investigators' Research Award (MIRA) (R35 - Clinical Trial Optional)
- Administrative Supplements to Existing NIH Grants and Cooperative Agreements (Parent Admin Supp Clinical Trial Optional)