PAR-23-219: SBIR/STTR Commercialization Readiness Pilot (CRP) Program Technical Assistance and Late Stage Development (SB1, Clinical Trial Not Allowed)
Closed
This grant is closed. Who won this program's grants before is below, and similar open grants are at the end of the page. It is in our archive of National Institutes of Health notices from 2023.
National Institutes of Health offered grants to small businesses. Applications closed on September 5, 2025.
From the official notice on Grants.gov, last changed April 3, 2025. Checked November 7, 2026.
- Award amountsNot given on Grants.gov
- Cost sharingNot required
- Funding typeGrant
About this NIH notice
- Activity codeSB1
- Clinical trialsNot allowed
- Funded byNHLBI, NIAID, NIA
- Median yearly award$906,297
- Typical project length2 years
Projects funded under PAR-23-219 were run by National Heart Lung and Blood Institute (NHLBI, 16 projects), National Institute of Allergy and Infectious Diseases (NIAID, 10 projects), National Institute on Aging (NIA, 7 projects) and National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS, 5 projects), and 11 more. Contact the program officer at the institute that fits your project before you apply; the notice lists them.
Application due dates, page limits and budget limits are set in the notice. Read PAR-23-219 in the NIH Guide.
Key dates
| Posted | July 12, 2023 |
|---|---|
| Deadline | September 5, 2025 |
| Archived by Grants.gov | October 5, 2025 |
Who can apply
This opportunity was open to small businesses.
- Small businesses
Other Eligible Applicants include the following:Non-domestic (non-U.S.) Entities (Foreign Institutions) are not eligible to apply. Non-domestic (non-U.S.) components of U.S. Organizations are not eligible to apply. Foreign components, as defined in the NIH Grants Policy Statement, may be allowed.
Is this a realistic fit?
- Most of the money in the 18 programs behind this notice (70% over five years) went to colleges and universities.
- No cost sharing or match is required.
What the grant funds
The purpose of this Notice of Funding Opportunity (NOFO) is to encourage applications from small business concerns (SBCs) to the newly re-authorized Commercialization Readiness Pilot (CRP) program. The NOFO aims to facilitate the transition of previously or currently funded SBIR and STTR Phase II and Phase IIB projects to the commercialization stage by providing additional support for technical assistance and later stage research and development (R and D) not typically supported through Phase II or Phase IIB grants or contracts. This may include independent replication of key studies, Investigational New Drug (IND)-enabling studies, clinical studies, manufacturing costs, regulatory assistance, or a combination of services. Although a significant amount of the work in a CRP award may be subcontracted to other institutions, the Small Business Concern (SBC) is expected to maintain oversight and management of the R and D throughout the award. Clinical Trials are not accepted under this NOFO.
Funded under PAR-23-219 so far
NIH funded 62 projects under PAR-23-219 in fiscal 2024 to 2026, at 60 institutions. The median yearly award was $906,297.
| Project | Institution | Fiscal year | Award |
|---|---|---|---|
| Commercial Readiness of a Catheter for Complex Percutaneous Coronary Intervention | Vantis Vascular Inc | 2026 | $496,437 |
| Scale-up manufacturing of microneedle stamp for peanut allergen immunotherapy | Moonlight Therapeutics, Inc. | 2026 | $999,380 |
| Commercialization Readiness Pilot Program support for: HEMOLINK | Aventusoft, LLC | 2026 | $500,000 |
| Readying the commercialization of Omega device as an improved safe and efficacious treatment for drug-failed GERD patients | Aplos Medical Inc | 2026 | $429,295 |
| Human Antibody for Acute Infection Treatment of RSV | Trellis Bioscience, Inc. | 2026 | $999,759 |
| Commercialization Readiness for a Portable PET Insert System for Simultaneous TOF-PET and MR Brain Imaging | Petcoil, Inc. | 2026 | $1.3 million |
| Novel, Non-hormonal Therapeutic for Endometriosis | Endomet Biosciences, Inc | 2026 | $2.0 million |
| A Point of Care Urine Test to Aid Diagnosis of Aspergillosis | Pearl Diagnostics, Inc. | 2026 | $977,071 |
Who has won Allergy and Infectious Diseases Research grants before
From fiscal 2021 to 2025, Allergy and Infectious Diseases Research (93.855) awarded $22 billion across 13,282 grant awards, an average of $1.6 million per award.
| Recipient | State | Awards | Amount |
|---|---|---|---|
| Fred Hutchinson Cancer Center | Washington | 85 | $938 million |
| Duke University | North Carolina | 230 | $781 million |
| University of California, Los Angeles | California | 138 | $745 million |
| The Johns Hopkins University | Maryland | 321 | $668 million |
| Emory University | Georgia | 282 | $650 million |
Who has won Cardiovascular Diseases Research grants before
From fiscal 2021 to 2025, Cardiovascular Diseases Research (93.837) awarded $15 billion across 11,798 grant awards, an average of $1.2 million per award.
| Recipient | State | Awards | Amount |
|---|---|---|---|
| The Trustees of the University of Pennsylvania | Pennsylvania | 313 | $380 million |
| Brigham & Womens Hospital Inc | Massachusetts | 274 | $374 million |
| Regents of the University of Michigan | Michigan | 277 | $355 million |
| The Trustees of Columbia University in the City of New York | New York | 207 | $335 million |
| University of Pittsburgh - of the Commonwealth System of Higher Education | Pennsylvania | 295 | $320 million |
Who has won Diabetes, Digestive, and Kidney Diseases Extramural Research grants before
From fiscal 2021 to 2025, Diabetes, Digestive, and Kidney Diseases Extramural Research (93.847) awarded $9.6 billion across 7,877 grant awards, an average of $1.2 million per award.
| Recipient | State | Awards | Amount |
|---|---|---|---|
| Regents of the University of Michigan | Michigan | 273 | $345 million |
| The Trustees of the University of Pennsylvania | Pennsylvania | 187 | $272 million |
| University of Pittsburgh - of the Commonwealth System of Higher Education | Pennsylvania | 209 | $238 million |
| The Washington University | Missouri | 187 | $227 million |
| The Regents of the University of California, San Francisco | California | 176 | $208 million |
Other programs behind this notice
- Extramural Research Programs in the Neurosciences and Neurological Disorders
- Mental Health Research Grants
- Cancer Treatment Research
- Vision Research
- National Center for Advancing Translational Sciences
- Cancer Detection and Diagnosis Research
- Arthritis, Musculoskeletal and Skin Diseases Research
- Alcohol Research Programs
- Human Genome Research
- Environmental Health
- Research Related to Deafness and Communication Disorders
- Oral Diseases and Disorders Research
- Discovery and Applied Research for Technological Innovations to Improve Human Health
- Lung Diseases Research
- Translation and Implementation Science Research for Heart, Lung, Blood Diseases, and Sleep Disorders
Applying now
This notice no longer takes applications. Agencies often post the same opportunity again under a new number, so check the program's notices on Grants.gov and the similar open grants below.
The notice on Grants.gov keeps its full text and attachments, which is useful for planning a resubmission.
Questions people ask
Is PAR-23-219 still open?
No. It closed on September 5, 2025.
Who can apply for SBIR/STTR Commercialization Readiness Pilot (CRP) Program Technical Assistance and Late Stage Development (SB1, Clinical Trial Not Allowed)?
National Institutes of Health accepted applications from small businesses. The notice adds further conditions, so read its eligibility section.
What is the deadline for SBIR/STTR Commercialization Readiness Pilot (CRP) Program Technical Assistance and Late Stage Development (SB1, Clinical Trial Not Allowed)?
Closed September 5, 2025. Applications are no longer accepted; the program's newer notices are on this page when there are any.
Who has been funded under PAR-23-219?
NIH RePORTER lists 62 projects funded under PAR-23-219 in fiscal 2024 to 2026, at 60 institutions. The most were at Aventusoft, LLC, Starlight Cardiovascular, Inc., Vantis Vascular Inc.
Who has won Environmental Health grants before?
The largest recipients over five fiscal years were Icahn School of Medicine at Mount Sinai, The Trustees of Columbia University in the City of New York, University of North Carolina at Chapel Hill. The program made 1,980 awards worth $2.1 billion in that time.
Similar open grants
- Change of Recipient Organization (Type 7 Parent Clinical Trial Optional)
- Successor-in-Interest (Type 6 Parent Clinical Trial Optional)
- SBIR/STTR Commercialization Readiness Pilot (CRP) Program (Parent SB1 Clinical Trial Optional)
- Data Coordinating Center for the Aging and Alzheimer’s Disease Mouse Brain Atlas (AD-MBA) (U24 Clinical Trial Not Allowed)
- Amyotrophic Lateral Sclerosis (ALS) Intermediate Patient Population Expanded Access (U01 Clinical Trial Required)
- Advanced Development and Validation of Emerging Technologies for Basic and Clinical Cancer Research (R33 Clinical Trial Not Allowed)