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Grants / Department of Health and Human Services / National Institutes of Health

PAR-21-333: NCI Outstanding Investigator Award (R35 Clinical Trial Not Allowed)

Closed Closed November 4, 2021 Opportunity PAR-21-333

This grant is closed. Who won this program's grants before is below, and similar open grants are at the end of the page. It is in our archive of National Institutes of Health notices from 2021.

National Institutes of Health offered grants of up to $600,000 to nonprofits, colleges and universities, state and local governments, tribes, small businesses and businesses. Applications closed on November 4, 2021.

From the official notice on Grants.gov, last changed September 20, 2021. Checked November 7, 2026.

About this NIH notice

Projects funded under PAR-21-333 were run by National Cancer Institute (NCI, 24 projects). Contact the program officer at the institute that fits your project before you apply; the notice lists them.

Application due dates, page limits and budget limits are set in the notice. Read PAR-21-333 in the NIH Guide.

Key dates

PostedSeptember 20, 2021
DeadlineNovember 4, 2021
Archived by Grants.govDecember 10, 2021

Who can apply

This opportunity was open to nonprofits, colleges and universities, state and local governments, tribes, small businesses and businesses.

All 15 applicant types the notice lists

Other Eligible Applicants include the following: Alaska Native and Native Hawaiian Serving Institutions; Asian American Native American Pacific Islander Serving Institutions (AANAPISISs); Eligible Agencies of the Federal Government; Faith-based or Community-based Organizations; Hispanic-serving Institutions; Historically Black Colleges and Universities (HBCUs); Indian/Native American Tribal Governments (Other than Federally Recognized); Non-domestic (non-U.S.) Entities (Foreign Organizations); Regional Organizations; Tribally Controlled Colleges and Universities (TCCUs) ; U.S. Territory or Possession; Non-domestic (non-U.S.) Entities (Foreign Institutions) are not eligible to apply. Non-domestic (non-U.S.) components of U.S. Organizations are not eligible to apply. Foreign components, as defined in the NIH Grants Policy Statement, are allowed.

More grants for nonprofits, colleges and universities, state and local governments, tribes, small businesses, businesses.

Is this a realistic fit?

What the grant funds

This Funding Opportunity Announcement (FOA) invites grant applications for the Outstanding Investigator Award (R35) in any area of cancer research. The objective of the National Cancer Institute (NCI) Outstanding Investigator Award (OIA) is to provide long-term support to accomplished investigators with outstanding records of cancer research productivity who propose to conduct exceptional research. The OIA is intended to allow investigators the opportunity to take greater risks, be more adventurous in their lines of inquiry, or take the time to develop new techniques. The OIA would allow an Institution to submit applications nominating established Program Directors/Principal Investigators (PDs/PIs) for the NCI OIA. It is expected that the OIA would provide extended funding stability and encourage investigators to embark on projects of unusual potential in cancer research. The research projects should break new ground or extend previous discoveries toward new directions or applications that may lead to a breakthrough that will advance biomedical, behavioral, or clinical cancer research.

Category: Education, Health.

Funded under PAR-21-333 so far

NIH funded 24 projects under PAR-21-333 in fiscal 2022 to 2026, at 20 institutions. The median yearly award was $941,030.

Most projects: Harvard University D/B/a Harvard School of Public Health (Massachusetts), 2, Dana-Farber Cancer Inst (Massachusetts), 2, University of TX MD Anderson Can Ctr (Texas), 2, Rockefeller University (New York), 2, University of Pennsylvania (Pennsylvania), 1.

Recently funded projects
ProjectInstitutionFiscal yearAward
Interaction between nuclear epigenetic and metabolic pathways in cancer R35University of Pennsylvania2026$975,000
Statistical Methods for Analysis of Massive Genetic and Genomic Data in Cancer Research R35Harvard University D/B/a Harvard School of Public Health2026$933,889
Leveraging the National Cancer Institute’s Cancer Center Cessation Initiative (C3I) Program to Evaluate and Transform Smoking Cessation Treatment in Cancer Care R35University of Wisconsin-Madison2026$933,000
Next Generation Cancer Immunotherapies to Defeat Melanoma R35University of California Los Angeles2026$936,000
Stalled replication fork repair in cancer predisposition and cancertherapy R35Beth Israel Deaconess Medical Center2026$1.0 million
Behavioral and Psychosocial Effects on Study Outcomes in End-Stage Cancer Treatment (BEST End-Stage Cancer Study) R35Weill Medical Coll of Cornell Univ2026$796,570
Decoding and Targeting the PI3K-mTOR Signaling Network in Cancer R35Harvard University D/B/a Harvard School of Public Health2026$959,712
Molecular Prediction of Myeloma Initiation Molecular Prediction of Myeloma Initiation R35Dana-Farber Cancer Inst2026$1.0 million

From NIH RePORTER, which lists each project once per fiscal year it was funded. Amounts are the yearly award.

Who has won Cancer Treatment Research grants before

From fiscal 2021 to 2025, Cancer Treatment Research (93.395) awarded $5.6 billion across 3,622 grant awards, an average of $1.5 million per award.

Largest recipients, fiscal 2021 to 2025
RecipientStateAwardsAmount
The Univeristy of Texas M.D. Anderson Cancer CenterTexas144$188 million
Dana-Farber Cancer Institute, Inc.Massachusetts68$185 million
Icahn School of Medicine at Mount SinaiNew York35$179 million
Public Health InstituteCalifornia4$168 million
Fred Hutchinson Cancer CenterWashington57$156 million

Top states: California ($843 million), New York ($604 million), Massachusetts ($568 million), Texas ($444 million), Pennsylvania ($417 million).

Who has won Cancer Biology Research grants before

From fiscal 2021 to 2025, Cancer Biology Research (93.396) awarded $4.3 billion across 3,142 grant awards, an average of $1.4 million per award.

Largest recipients, fiscal 2021 to 2025
RecipientStateAwardsAmount
The Trustees of Columbia University in the City of New YorkNew York70$151 million
The Univeristy of Texas M.D. Anderson Cancer CenterTexas109$144 million
Sloan-Kettering Institute for Cancer ResearchNew York66$136 million
Dana-Farber Cancer Institute, Inc.Massachusetts47$107 million
The Regents of the University of California, San FranciscoCalifornia64$95.5 million

Top states: New York ($712 million), California ($608 million), Massachusetts ($409 million), Texas ($373 million), Pennsylvania ($286 million).

Who has won Cancer Cause and Prevention Research grants before

From fiscal 2021 to 2025, Cancer Cause and Prevention Research (93.393) awarded $3.6 billion across 2,517 grant awards, an average of $1.4 million per award.

Largest recipients, fiscal 2021 to 2025
RecipientStateAwardsAmount
The Univeristy of Texas M.D. Anderson Cancer CenterTexas81$107 million
Sloan-Kettering Institute for Cancer ResearchNew York65$99.1 million
The Trustees of Columbia University in the City of New YorkNew York48$85.3 million
Dana-Farber Cancer Institute, Inc.Massachusetts51$83.1 million
University of North Carolina at Chapel HillNorth Carolina49$76.1 million

Top states: California ($465 million), New York ($445 million), Massachusetts ($350 million), Texas ($259 million), Pennsylvania ($175 million).

Other programs behind this notice

Applying now

This notice no longer takes applications. Agencies often post the same opportunity again under a new number, so check the program's notices on Grants.gov and the similar open grants below.

The notice on Grants.gov keeps its full text and attachments, which is useful for planning a resubmission.

Questions people ask

Is PAR-21-333 still open?

No. It closed on November 4, 2021.

Who can apply for NCI Outstanding Investigator Award (R35 Clinical Trial Not Allowed)?

National Institutes of Health accepted applications from nonprofits, colleges and universities, state and local governments, tribes, small businesses and businesses. The notice adds further conditions, so read its eligibility section.

What is the deadline for NCI Outstanding Investigator Award (R35 Clinical Trial Not Allowed)?

Closed November 4, 2021. Applications are no longer accepted; the program's newer notices are on this page when there are any.

How much funding is available?

Awards of up to $600,000 each.

Who has been funded under PAR-21-333?

NIH RePORTER lists 24 projects funded under PAR-21-333 in fiscal 2022 to 2026, at 20 institutions. The most were at Harvard University D/B/a Harvard School of Public Health, Dana-Farber Cancer Inst, University of TX MD Anderson Can Ctr.

Who has won Cancer Cause and Prevention Research grants before?

The largest recipients over five fiscal years were The Univeristy of Texas M.D. Anderson Cancer Center, Sloan-Kettering Institute for Cancer Research, The Trustees of Columbia University in the City of New York. The program made 2,517 awards worth $3.6 billion in that time.

Similar open grants