Federal grants to Mayo Clinic
Mayo Clinic in Rochester, Minnesota received $1.4 billion in federal grants from fiscal 2021 to 2025, across 875 awards. Its largest program was Aging Research, with $255 million. In fiscal 2025 it was awarded $282 million.
From USAspending.gov award records, updated October 31, 2026.
- Grants, FY 2021 to 2025$1.4 billion
- Awards875
- Awarded in FY 2025$282 million
- Largest award$68.9 million
By year
| Fiscal year | Awards | Amount |
|---|---|---|
| FY 2021 | 436 | $253 million |
| FY 2022 | 446 | $263 million |
| FY 2023 | 431 | $288 million |
| FY 2024 | 458 | $290 million |
| FY 2025 | 432 | $282 million |
Programs that fund Mayo Clinic
| Program | Awards | Amount |
|---|---|---|
| Aging Research | 110 | $255 million |
| Diabetes, Digestive, and Kidney Diseases Extramural Research | 133 | $169 million |
| Cardiovascular Diseases Research | 107 | $136 million |
| Cancer Treatment Research | 49 | $103 million |
| 21st Century Cures Act - Precision Medicine Initiative | 2 | $69.2 million |
| Extramural Research Programs in the Neurosciences and Neurological Disorders | 55 | $67.5 million |
| Cancer Cause and Prevention Research | 37 | $63.9 million |
| Military Medical Research and Development | 51 | $57.8 million |
| Cancer Centers Support Grants | 4 | $57.6 million |
| National Center for Advancing Translational Sciences | 6 | $49.9 million |
Awarding agencies
| Agency | Awards | Amount |
|---|---|---|
| Department of Health and Human Services | 812 | $1.3 billion |
| Department of Defense | 51 | $57.8 million |
| National Science Foundation | 9 | $3.5 million |
| Department of Education | 2 | $1.3 million |
| National Aeronautics and Space Administration | 1 | $233 |
Largest awards
| Award | Program | First action | Amount |
|---|---|---|---|
| Precision medicine initiative cohort program biobank | 21st Century Cures Act - Precision Medicine Initiative | September 8, 2022 | $68.9 million |
| Artfl lefftds longitudinal frontotemporal lobar degeneration (ALLFTD) | Aging Research | July 13, 2021 | $47.7 million |
| Statistics and data center for the alliance for clinical trials in oncology | Cancer Treatment Research | October 27, 2020 | $41.8 million |
| Mayo clinic center for clinical and translational science (CCATS) | National Center for Advancing Translational Sciences | November 12, 2020 | $35.4 million |
| Mayo comprehensive cancer center grant | Cancer Centers Support Grants | October 15, 2020 | $28.9 million |
| Mayo alzheimer's disease research center | Aging Research | January 15, 2021 | $18.5 million |
| Targeting cellular senescence to extend healthspan | Aging Research | February 11, 2021 | $15.5 million |
| BETA1-SELECTIVE blockade for prevention of postmenopausal bone loss: a randomized controlled trial - osteoporosis is a disease of aging that leads to ~2 million fractures and ~$17 billion in healthcare costs annually. Although several drugs are fda-approved for the treatment of osteoporosis, the pot | Aging Research | December 24, 2020 | $12.0 million |
| Alzheimer disease patient registry | Aging Research | January 15, 2021 | $12.0 million |
| Longitudinal imaging biomarkers of disease progression in dlb | Aging Research | August 9, 2021 | $10.8 million |
Questions people ask
How much federal grant money does Mayo Clinic get?
$1.4 billion in 875 grant awards from fiscal 2021 to 2025, as obligations reported to USAspending.gov.
Which agency gives Mayo Clinic the most?
The Department of Health and Human Services, with $1.3 billion in 812 awards. The Department of Defense and the National Science Foundation follow.
What is Mayo Clinic's largest federal grant?
$68.9 million under 21st Century Cures Act - Precision Medicine Initiative, with its first action in the period on September 8, 2022. That counts only the money obligated in fiscal 2021 to 2025.
Which federal programs fund Mayo Clinic?
Its largest are Aging Research, Diabetes, Digestive, and Kidney Diseases Extramural Research and Cardiovascular Diseases Research.
Other grant recipients in Rochester
- City of Rochester
- Child Care Resource & Referral Inc
- Rochester Community & Technical College
- Rochester Airport Company
- Olmsted County Housing and Redevelopment Authority, Minnesota
- Emmyon, Inc.
- Sersense Inc
- Piraeus Medical, Inc.
Largest federal grant recipients in Minnesota · Federal grants in Minnesota