RFA-RM-24-004: NIH Directors Transformative Research Awards (R01 Clinical Trial Optional)
Closed
This grant is closed. Who won this program's grants before is below, and similar open grants are at the end of the page. It is in our archive of National Institutes of Health notices from 2024.
National Institutes of Health offered grants to nonprofits, colleges and universities, state and local governments, tribes, small businesses and businesses. Applications closed on September 3, 2024.
From the official notice on Grants.gov, last changed March 18, 2024. Checked November 7, 2026.
- Award amountsNot given on Grants.gov
- Cost sharingNot required
- Funding typeGrant
About this NIH notice
- Activity codeR01
- Clinical trialsOptional
- Funded byNCCIH, NINDS, NIA
- Median yearly award$1.1 million
- Typical project length5 years
- R01, Research Project Grant. NIH's standard grant for a defined research project led by a named investigator, usually for up to five years. Other open R01 notices.
Projects funded under RFA-RM-24-004 were run by National Center for Complementary and Integrative Health (NCCIH, 2 projects), National Institute of Neurological Disorders and Stroke (NINDS, 1 project), National Institute on Aging (NIA, 1 project) and National Cancer Institute (NCI, 1 project), and 1 more. Contact the program officer at the institute that fits your project before you apply; the notice lists them.
Application due dates, page limits and budget limits are set in the notice. Read RFA-RM-24-004 in the NIH Guide.
Other notices with this title
| Notice | Posted | Deadline | Status |
|---|---|---|---|
| RFA-RM-25-003 | June 16, 2025 | Closed September 3, 2025 | Closed |
| RFA-RM-23-006 | March 27, 2023 | Closed September 1, 2023 | Closed |
| RFA-RM-22-020 | May 12, 2022 | Closed September 1, 2022 | Closed |
| RFA-RM-21-017 | June 4, 2021 | Closed September 1, 2021 | Closed |
Key dates
| Posted | March 18, 2024 |
|---|---|
| Deadline | September 3, 2024 |
| Archived by Grants.gov | October 9, 2024 |
Who can apply
This opportunity was open to nonprofits, colleges and universities, state and local governments, tribes, small businesses and businesses.
All 15 applicant types the notice lists
- State governments
- County governments
- City or township governments
- Special district governments
- Independent school districts
- Public and State controlled institutions of higher education
- Native American tribal governments (Federally recognized)
- Public housing authorities/Indian housing authorities
- Native American tribal organizations (other than Federally recognized tribal governments)
- Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education
- Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education
- Private institutions of higher education
- For profit organizations other than small businesses
- Small businesses
- Others (see text field entitled "Additional Information on Eligibility" for clarification)
Other Eligible Applicants include the following: Alaska Native and Native Hawaiian Serving Institutions; Asian American Native American Pacific Islander Serving Institutions (AANAPISISs); Eligible Agencies of the Federal Government; Faith-based or Community-based Organizations; Hispanic-serving Institutions; Historically Black Colleges and Universities (HBCUs); Indian/Native American Tribal Governments (Other than Federally Recognized); Non-domestic (non-U.S.) Entities (Foreign Organizations); Regional Organizations; Tribally Controlled Colleges and Universities (TCCUs) ; U.S. Territory or Possession; Non-domestic (non-U.S.) Entities (Foreign Organizations) are not eligible to apply. Non-domestic (non-U.S.) components of U.S. Organizations are not eligible to apply. Foreign components, as defined in the NIH Grants Policy Statement, are allowed.
Is this a realistic fit?
- Most of the program's money (72% over five years) went to colleges and universities.
- No cost sharing or match is required.
What the grant funds
The NIH Directors Transformative Research Award Program supports individual scientists or groups of scientists proposing bold, groundbreaking, exceptionally innovative, original, and/or unconventional research with the potential to create new scientific paradigms, establish entirely new and improved clinical approaches, or develop transformative technologies. To support innovative and novel research across the vast NIH mission, individuals from diverse backgrounds (including those from underrepresented groups; see Notice of NIHs Interest in Diversity) and from the full spectrum of eligible institutions in all geographic locations are encouraged to apply to this Notice of Funding Opportunity. Applications in all topics relevant to the broad mission of NIH are welcome in all topic areas relevant to the broad mission of NIH, including, but not limited to, behavioral, social, biomedical, applied, and formal sciences and topics that may involve basic, translational, or clinical research. No preliminary data are required. Projects must clearly demonstrate, based on the strength of the logic, a compelling potential to produce a major impact in a broad area of relevance to the NIH. The NIH Directors Transformative Research Award is a component of the High-Risk, High-Reward Research (HRHR) Program of the NIH Common Fund. Towards the objective of funding the best possible science, the Office of Strategic Coordination and the Center for Scientific Review are piloting a process for initial peer review of applications received in response to this FOA in which the identity of the investigators and institutions are withheld until the last phase of review. Instructions for anonymizing components of the application are given in Section IV and must be carefully followed. A description of the review process is given in Section V.
Funded under RFA-RM-24-004 so far
NIH funded 6 projects under RFA-RM-24-004 in fiscal 2025 to 2026, at 6 institutions. The median yearly award was $1.1 million.
| Project | Institution | Fiscal year | Award |
|---|---|---|---|
| I/O Tags: Genetically Encoded Tags for Trans-Neuronal Control Across Specific Synapse Classes | Henry Ford Health + Michigan State University Health Sciences | 2026 | $751,194 |
| Building a somatosensory atlas for interoception | The Scripps Research Institute | 2026 | $2.8 million |
| Restoring Cognitive Function through Precision Neurostimulation: A Disease-Agnostic Approach Based on Convergent Hippocampal Dynamics. | Nemours Children's Hospital, Delaware | 2026 | $526,638 |
| A Revitalized Framework for Vitamin Biology: New Sensors, Pathways and Precision Therapies | J. David Gladstone Institutes | 2026 | $1.3 million |
| Targeting cancer metastasis by inhibiting curvature-induced kinase activation | Stanford University | 2026 | $982,313 |
| Networking the parental brain: Transformation of brain-wide electrical networks | University of Iowa | 2026 | $1.1 million |
Who has won Trans-NIH Research Support grants before
From fiscal 2021 to 2025, Trans-NIH Research Support (93.310) awarded $5.9 billion across 4,433 grant awards, an average of $1.3 million per award.
| Recipient | State | Awards | Amount |
|---|---|---|---|
| Duke University | North Carolina | 66 | $219 million |
| The Leland Stanford Junior University | California | 104 | $176 million |
| University of Pittsburgh - of the Commonwealth System of Higher Education | Pennsylvania | 82 | $154 million |
| The Johns Hopkins University | Maryland | 95 | $152 million |
| Yale Univ | Connecticut | 85 | $149 million |
Applying now
This notice no longer takes applications. Agencies often post the same opportunity again under a new number, so check the program's notices on Grants.gov and the similar open grants below.
The notice on Grants.gov keeps its full text and attachments, which is useful for planning a resubmission.
Questions people ask
Is RFA-RM-24-004 still open?
No. It closed on September 3, 2024.
Who can apply for NIH Directors Transformative Research Awards (R01 Clinical Trial Optional)?
National Institutes of Health accepted applications from nonprofits, colleges and universities, state and local governments, tribes, small businesses and businesses. The notice adds further conditions, so read its eligibility section.
What is the deadline for NIH Directors Transformative Research Awards (R01 Clinical Trial Optional)?
Closed September 3, 2024. Applications are no longer accepted; the program's newer notices are on this page when there are any.
Who has been funded under RFA-RM-24-004?
NIH RePORTER lists 6 projects funded under RFA-RM-24-004 in fiscal 2025 to 2026, at 6 institutions. The most were at Henry Ford Health + Michigan State University Health Sciences, The Scripps Research Institute, Nemours Children's Hospital, Delaware.
Who has won Trans-NIH Research Support grants before?
The largest recipients over five fiscal years were Duke University, The Leland Stanford Junior University, University of Pittsburgh - of the Commonwealth System of Higher Education. The program made 4,433 awards worth $5.9 billion in that time.
Similar open grants
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- Ethical, Legal and Social Implications (ELSI) Research (R01 Clinical Trial Optional)
- Competing Revisions to Existing NIH Single Project Research Grants and Cooperative Agreements (Clinical Trial Optional)
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