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Grants / Department of Health and Human Services / National Institutes of Health

RFA-RM-23-006: NIH Directors Transformative Research Awards (R01 Clinical Trial Optional)

Closed Closed September 1, 2023 Opportunity RFA-RM-23-006

This grant is closed. Who won this program's grants before is below, and similar open grants are at the end of the page. It is in our archive of National Institutes of Health notices from 2023.

National Institutes of Health offered grants to nonprofits, colleges and universities, state and local governments, tribes, small businesses and businesses. Applications closed on September 1, 2023.

From the official notice on Grants.gov, last changed March 28, 2023. Checked November 7, 2026.

About this NIH notice

Projects funded under RFA-RM-23-006 were run by National Institute of Mental Health (NIMH, 1 project), National Institute of Environmental Health Sciences (NIEHS, 1 project), National Cancer Institute (NCI, 1 project) and National Institute of Biomedical Imaging and Bioengineering (NIBIB, 1 project), and 3 more. Contact the program officer at the institute that fits your project before you apply; the notice lists them.

Application due dates, page limits and budget limits are set in the notice. Read RFA-RM-23-006 in the NIH Guide.

Other notices with this title

National Institutes of Health has posted this title under other numbers: earlier or later rounds, or the same competition for another area. Each has its own dates and may change its rules.

NoticePostedDeadlineStatus
RFA-RM-25-003June 16, 2025Closed September 3, 2025Closed
RFA-RM-24-004March 18, 2024Closed September 3, 2024Closed
RFA-RM-22-020May 12, 2022Closed September 1, 2022Closed
RFA-RM-21-017June 4, 2021Closed September 1, 2021Closed

Key dates

PostedMarch 27, 2023
DeadlineSeptember 1, 2023
Archived by Grants.govOctober 7, 2023

Who can apply

This opportunity was open to nonprofits, colleges and universities, state and local governments, tribes, small businesses and businesses.

All 15 applicant types the notice lists

Other Eligible Applicants include the following: Alaska Native and Native Hawaiian Serving Institutions; Asian American Native American Pacific Islander Serving Institutions (AANAPISISs); Eligible Agencies of the Federal Government; Faith-based or Community-based Organizations; Hispanic-serving Institutions; Historically Black Colleges and Universities (HBCUs); Indian/Native American Tribal Governments (Other than Federally Recognized); Non-domestic (non-U.S.) Entities (Foreign Organizations); Regional Organizations; Tribally Controlled Colleges and Universities (TCCUs) ; U.S. Territory or Possession; Non-domestic (non-U.S.) Entities (Foreign Institutions) are not eligible to apply. Non-domestic (non-U.S.) components of U.S. Organizations are not eligible to apply. Foreign components, as defined in the NIH Grants Policy Statement, are allowed.

More grants for nonprofits, colleges and universities, state and local governments, tribes, small businesses, businesses.

Is this a realistic fit?

What the grant funds

The NIH Directors Transformative Research Award Program supports individual scientists or groups of scientists proposing groundbreaking, exceptionally innovative, original, and/or unconventional research with the potential to create new scientific paradigms, establish entirely new and improved clinical approaches, or develop transformative technologies. For the program to support the best possible researchers and research, applications are sought which reflect the full diversity of the nations research workforce. Individuals from diverse backgrounds, including those from underrepresented groups (see, Notice of NIH's Interest in Diversity, NOT-OD-20-031) are strongly encouraged to apply to this Funding Opportunity Announcement. In addition, applications are welcome from the full spectrum of eligible institutions in all geographic locations and in all topic areas relevant to the broad mission of NIH, including, but not limited to, behavioral, social, biomedical, applied, and formal sciences and topics that may involve basic, translational, or clinical research. No preliminary data are required. Projects must clearly demonstrate, based on the strength of the logic, a compelling potential to produce a major impact in a broad area of relevance to the NIH. The NIH Directors Transformative Research Award is a component of the High-Risk, High-Reward Research program of the NIH Common Fund. Towards the objective of funding the best possible science, the Office of Strategic Coordination and the Center for Scientific Review are piloting a process for initial peer review of applications received in response to this FOA in which the identity of the investigators and institutions are withheld until the last phase of review. Instructions for anonymizing components of the application are given in Section IV and must be carefully followed. A description of the review process is given in Section V.

Category: Health.

Funded under RFA-RM-23-006 so far

NIH funded 7 projects under RFA-RM-23-006 in fiscal 2024 to 2026, at 7 institutions. The median yearly award was $1.5 million.

Recently funded projects
ProjectInstitutionFiscal yearAward
Astrocytes as the integrators of neuromodulator signals R01New York State Psychiatric Institute DBA Research Foundation for Mental Hygiene, Inc2026$1.4 million
Functional characterization of cell surface RNA biology R01Boston Children's Hospital2026$2.5 million
Resolving transcription factor target search mechanisms R01Massachusetts Institute of Technology2026$1.8 million
Programming cellular behavior by mechanical forces R01Yale University2026$4.3 million
Activity Probes to Guide Precision Microbiome Therapy R01Weill Medical Coll of Cornell Univ2026$3.3 million
Evolution of Mammalian Sex Chromosome Dosage Compensation R01University of Michigan at Ann Arbor2026$2.7 million
A spatial view of hematopoietic regeneration dynamics in the bone marrow R01University of Southern California2026$4.9 million

From NIH RePORTER, which lists each project once per fiscal year it was funded. Amounts are the yearly award.

Who has won Trans-NIH Research Support grants before

From fiscal 2021 to 2025, Trans-NIH Research Support (93.310) awarded $5.9 billion across 4,433 grant awards, an average of $1.3 million per award.

Largest recipients, fiscal 2021 to 2025
RecipientStateAwardsAmount
Duke UniversityNorth Carolina66$219 million
The Leland Stanford Junior UniversityCalifornia104$176 million
University of Pittsburgh - of the Commonwealth System of Higher EducationPennsylvania82$154 million
The Johns Hopkins UniversityMaryland95$152 million
Yale UnivConnecticut85$149 million

Top states: California ($992 million), Massachusetts ($571 million), New York ($548 million), Pennsylvania ($445 million), North Carolina ($387 million).

Applying now

This notice no longer takes applications. Agencies often post the same opportunity again under a new number, so check the program's notices on Grants.gov and the similar open grants below.

The notice on Grants.gov keeps its full text and attachments, which is useful for planning a resubmission.

Questions people ask

Is RFA-RM-23-006 still open?

No. It closed on September 1, 2023.

Who can apply for NIH Directors Transformative Research Awards (R01 Clinical Trial Optional)?

National Institutes of Health accepted applications from nonprofits, colleges and universities, state and local governments, tribes, small businesses and businesses. The notice adds further conditions, so read its eligibility section.

What is the deadline for NIH Directors Transformative Research Awards (R01 Clinical Trial Optional)?

Closed September 1, 2023. Applications are no longer accepted; the program's newer notices are on this page when there are any.

Who has been funded under RFA-RM-23-006?

NIH RePORTER lists 7 projects funded under RFA-RM-23-006 in fiscal 2024 to 2026, at 7 institutions. The most were at New York State Psychiatric Institute DBA Research Foundation for Mental Hygiene, Inc, Boston Children's Hospital, Massachusetts Institute of Technology.

Who has won Trans-NIH Research Support grants before?

The largest recipients over five fiscal years were Duke University, The Leland Stanford Junior University, University of Pittsburgh - of the Commonwealth System of Higher Education. The program made 4,433 awards worth $5.9 billion in that time.

Similar open grants