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Grants / Department of Health and Human Services / National Institutes of Health

RFA-HL-23-005: NHLBI Emerging Investigator Award (EIA) (R35 Clinical Trial Optional)

Closed Closed April 25, 2024 Opportunity RFA-HL-23-005

This grant is closed. A newer notice from the same program is open now: NHLBI Emerging Investigator Award (EIA) (R35 Clinical Trial Optional) (RFA-HL-26-003). Status: Closes April 28, 2027 (172 days left). It is in our archive of National Institutes of Health notices from 2021.

National Institutes of Health offered grants of up to $700,000 to nonprofits, colleges and universities, state and local governments, tribes, small businesses and businesses. It expected to make about 20 awards worth $20.0 million in total. Applications closed on April 25, 2024.

From the official notice on Grants.gov, last changed May 5, 2021. Checked November 7, 2026.

About this NIH notice

Projects funded under RFA-HL-23-005 were run by National Heart Lung and Blood Institute (NHLBI, 10 projects). Contact the program officer at the institute that fits your project before you apply; the notice lists them.

Application due dates, page limits and budget limits are set in the notice. Read RFA-HL-23-005 in the NIH Guide.

Other notices with this title

National Institutes of Health has posted this title under other numbers: earlier or later rounds, or the same competition for another area. Each has its own dates and may change its rules.

NoticePostedDeadlineStatus
RFA-HL-26-003April 26, 2024Closes April 28, 2027 (172 days left)Open

Key dates

PostedMay 5, 2021
DeadlineApril 25, 2024
Archived by Grants.govMay 31, 2024

Who can apply

This opportunity was open to nonprofits, colleges and universities, state and local governments, tribes, small businesses and businesses.

All 15 applicant types the notice lists

Other Eligible Applicants include the following: Alaska Native and Native Hawaiian Serving Institutions; Asian American Native American Pacific Islander Serving Institutions (AANAPISISs); Eligible Agencies of the Federal Government; Faith-based or Community-based Organizations; Hispanic-serving Institutions; Historically Black Colleges and Universities (HBCUs); Indian/Native American Tribal Governments (Other than Federally Recognized); Regional Organizations; Tribally Controlled Colleges and Universities (TCCUs) ; U.S. Territory or Possession; Non-domestic (non-U.S.) Entities (Foreign Institutions) are not eligible to apply. Non-domestic (non-U.S.) components of U.S. Organizations are not eligible to apply. Foreign components, as defined in the NIH Grants Policy Statement, are allowed.

More grants for nonprofits, colleges and universities, state and local governments, tribes, small businesses, businesses.

Is this a realistic fit?

What the grant funds

The purpose of the NHLBI Emerging Investigator Award (EIA) is to promote scientific productivity and innovation by providing long-term support and increased flexibility to experienced Program Directors/Principal Investigators (PD/PIs) who are currently PD/PIs on at least two NHLBI R01-equivalent awards and whose outstanding record of research demonstrates their ability to make major contributions to heart, lung, blood and sleep (HLBS) research. The EIA is intended to support a research program, rather than a research project, by providing the primary and most likely sole source of NHLBI funding on individual grant awards. The EIA will support the research program of NHLBI-funded investigators for up to seven years. The EIA will provide investigators increased freedom to conduct research that breaks new ground or extends previous discoveries in new directions. It will also allow PD/PIs to take greater risks and to pursue research that requires a longer timeframe. Research supported by the EIA must be within the scope of the NHLBI mission (http://www.nhlbi.nih.gov/about/org/mission).

Category: Health.

Funded under RFA-HL-23-005 so far

NIH funded 10 projects under RFA-HL-23-005 in fiscal 2023 to 2026, at 10 institutions. The median yearly award was $873,329.

Recently funded projects
ProjectInstitutionFiscal yearAward
Deciphering how 3D genome organization orchestrates cardiac cellular identity R35University of Pennsylvania2026$866,687
Establishing lifelong trajectories of pulmonary health R35University of Rochester2026$844,477
Epigenetic regulation in cardiac development R35Texas A&m University Health Science Ctr2026$935,316
Genetic and Molecular Mechanisms of Heart Disease R35University of Iowa2026$1.1 million
Finding and pushing the limits of macrophage efferocytosis in atherosclerosis R35Columbia University Health Sciences2026$656,633
Cellular and Molecular Control of Normal and Disordered Erythropoiesis R35Feinstein Institute for Medical Research2026$853,132
The epigenetic regulation of inflammation in tissue repair and vascular disease R35University of Michigan at Ann Arbor2026$1.0 million
Sex-specific factors, inflammation and vascular health across the lifespan in women living with HIV R35Johns Hopkins University2026$484,874

From NIH RePORTER, which lists each project once per fiscal year it was funded. Amounts are the yearly award.

Who has won Cardiovascular Diseases Research grants before

From fiscal 2021 to 2025, Cardiovascular Diseases Research (93.837) awarded $15 billion across 11,798 grant awards, an average of $1.2 million per award.

Largest recipients, fiscal 2021 to 2025
RecipientStateAwardsAmount
The Trustees of the University of PennsylvaniaPennsylvania313$380 million
Brigham & Womens Hospital IncMassachusetts274$374 million
Regents of the University of MichiganMichigan277$355 million
The Trustees of Columbia University in the City of New YorkNew York207$335 million
University of Pittsburgh - of the Commonwealth System of Higher EducationPennsylvania295$320 million

Top states: California ($1.8 billion), Massachusetts ($1.5 billion), New York ($1.4 billion), Pennsylvania ($1.1 billion), Ohio ($749 million).

Who has won Lung Diseases Research grants before

From fiscal 2021 to 2025, Lung Diseases Research (93.838) awarded $8.7 million across 5 grant awards, an average of $1.7 million per award.

Largest recipients, fiscal 2021 to 2025
RecipientStateAwardsAmount
The General Hospital CorporationMassachusetts1$5.4 million
New England Research Institutes IncMassachusetts1$2.7 million
The Trustees of the University of PennsylvaniaPennsylvania1$355,699
University of WashingtonWashington1$350,272
The Trustees of Columbia University in the City of New YorkNew York1$319,659

Top states: Massachusetts ($7.8 million), Washington ($350,272), New York ($319,659), Pennsylvania ($300,836).

Who has won Translation and Implementation Science Research for Heart, Lung, Blood Diseases, and Sleep Disorders grants before

From fiscal 2021 to 2025, Translation and Implementation Science Research for Heart, Lung, Blood Diseases, and Sleep Disorders (93.840) awarded $3.3 million across 9 grant awards, an average of $364,164 per award.

Largest recipients, fiscal 2021 to 2025
RecipientStateAwardsAmount
The Regents of the University of ColoradoColorado1$1.5 million
Indiana Department of HealthIndiana1$558,986
Minnesota Department of HealthMinnesota1$442,754
Michigan Public Health InstituteMichigan1$311,837
City of PhiladelphiaPennsylvania1$251,231

Top states: Colorado ($1.5 million), Indiana ($558,986), Minnesota ($442,754), Michigan ($311,837), South Carolina ($191,177).

Applying now

This notice no longer takes applications. Apply under the newer notice, RFA-HL-26-003, which is open now.

The notice on Grants.gov keeps its full text and attachments, which is useful for planning a resubmission.

Questions people ask

Is RFA-HL-23-005 still open?

No. It closed on April 25, 2024. A newer notice is open: RFA-HL-26-003, closes April 28, 2027 (172 days left).

Who can apply for NHLBI Emerging Investigator Award (EIA) (R35 Clinical Trial Optional)?

National Institutes of Health accepted applications from nonprofits, colleges and universities, state and local governments, tribes, small businesses and businesses. The notice adds further conditions, so read its eligibility section.

What is the deadline for NHLBI Emerging Investigator Award (EIA) (R35 Clinical Trial Optional)?

Closed April 25, 2024. Applications are no longer accepted; the program's newer notices are on this page when there are any.

How much funding is available?

Awards of up to $700,000 each. About $20.0 million in total across about 20 awards.

Who has been funded under RFA-HL-23-005?

NIH RePORTER lists 10 projects funded under RFA-HL-23-005 in fiscal 2023 to 2026, at 10 institutions. The most were at University of Pennsylvania, University of Rochester, Texas A&m University Health Science Ctr.

Who has won Cardiovascular Diseases Research grants before?

The largest recipients over five fiscal years were The Trustees of the University of Pennsylvania, Brigham & Womens Hospital Inc, Regents of the University of Michigan. The program made 11,798 awards worth $15 billion in that time.

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