RFA-HG-21-006: Transformative Nucleic Acid Sequencing Technology Innovation and Early Development (R01 Clinical Trial Not Allowed)
Closed
This grant is closed. Who won this program's grants before is below, and similar open grants are at the end of the page. It is in our archive of National Institutes of Health notices from 2021.
National Institutes of Health offered grants to nonprofits, colleges and universities, state and local governments, tribes, small businesses and businesses. Applications closed on February 1, 2023.
From the official notice on Grants.gov, last changed March 30, 2021. Checked November 7, 2026.
- Award amountsNot given on Grants.gov
- Cost sharingNot required
- Funding typeGrant
About this NIH notice
- Activity codeR01
- Clinical trialsNot allowed
- Funded byNHGRI
- Median yearly award$765,367
- Typical project length4 years
- R01, Research Project Grant. NIH's standard grant for a defined research project led by a named investigator, usually for up to five years. Other open R01 notices.
Projects funded under RFA-HG-21-006 were run by National Human Genome Research Institute (NHGRI, 5 projects). Contact the program officer at the institute that fits your project before you apply; the notice lists them.
Application due dates, page limits and budget limits are set in the notice. Read RFA-HG-21-006 in the NIH Guide.
Key dates
| Posted | March 30, 2021 |
|---|---|
| Deadline | February 1, 2023 |
| Archived by Grants.gov | March 9, 2023 |
Who can apply
This opportunity was open to nonprofits, colleges and universities, state and local governments, tribes, small businesses and businesses.
All 15 applicant types the notice lists
- State governments
- County governments
- City or township governments
- Special district governments
- Independent school districts
- Public and State controlled institutions of higher education
- Native American tribal governments (Federally recognized)
- Public housing authorities/Indian housing authorities
- Native American tribal organizations (other than Federally recognized tribal governments)
- Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education
- Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education
- Private institutions of higher education
- For profit organizations other than small businesses
- Small businesses
- Others (see text field entitled "Additional Information on Eligibility" for clarification)
Other Eligible Applicants include the following: Alaska Native and Native Hawaiian Serving Institutions; Asian American Native American Pacific Islander Serving Institutions (AANAPISISs); Eligible Agencies of the Federal Government; Faith-based or Community-based Organizations; Hispanic-serving Institutions; Historically Black Colleges and Universities (HBCUs); Indian/Native American Tribal Governments (Other than Federally Recognized); Non-domestic (non-U.S.) Entities (Foreign Organizations); Regional Organizations; Tribally Controlled Colleges and Universities (TCCUs) ; U.S. Territory or Possession.
Is this a realistic fit?
- Most of the program's money (67% over five years) went to colleges and universities.
- No cost sharing or match is required.
What the grant funds
The National Human Genome Research Institute intends to promote a new initiative by publishing a Request for Applications to solicit R01 applications for research in the area of Transformative Nucleic Acid Sequencing Technology Innovation and Early Development: The purpose of the RFA is to refocus and emphasize NHGRIs investment in nucleic acid sequencing technology on novel technology innovation and early development. This Notice is being provided to allow potential applicants sufficient time to develop effective collaborations and responsive projects. The FOA is expected to be published in the winter of 2021 with an expected application due date in the summer of 2021.
Funded under RFA-HG-21-006 so far
NIH funded 5 projects under RFA-HG-21-006 in fiscal 2022 to 2026, at 4 institutions. The median yearly award was $765,367.
| Project | Institution | Fiscal year | Award |
|---|---|---|---|
| Development of Next-Generation Mass Spectrometry-based de novo RNA Sequencing for all Modifications | State University of New York at Albany | 2026 | $617,230 |
| Direct RNA sequencing using electo-optical zero mode waveguides and custom click fluorescent nucleotides | Northeastern University | 2026 | $1.0 million |
| Twice reading of RNA by direct nanopore sequencing | Thomas Jefferson University | 2026 | $112,568 |
| Synthetic mRNA Control Set for Nanopore-Based Pseudouridine Modification Profiling in Human Transcriptomes | Northeastern University | 2026 | $845,562 |
| Enzymeless, controlled electrostatic ratcheting in solid-state nanopores | Columbia Univ New York Morningside | 2025 | $735,000 |
Who has won Human Genome Research grants before
From fiscal 2021 to 2025, Human Genome Research (93.172) awarded $2.2 billion across 1,255 grant awards, an average of $1.7 million per award.
| Recipient | State | Awards | Amount |
|---|---|---|---|
| The Leland Stanford Junior University | California | 59 | $153 million |
| University of Washington | Washington | 46 | $123 million |
| The Broad Institute, Inc | Massachusetts | 22 | $119 million |
| University of California Santa Cruz | California | 17 | $64.7 million |
| Baylor College of Medicine | Texas | 24 | $62.9 million |
Applying now
This notice no longer takes applications. Agencies often post the same opportunity again under a new number, so check the program's notices on Grants.gov and the similar open grants below.
The notice on Grants.gov keeps its full text and attachments, which is useful for planning a resubmission.
Questions people ask
Is RFA-HG-21-006 still open?
No. It closed on February 1, 2023.
Who can apply for Transformative Nucleic Acid Sequencing Technology Innovation and Early Development (R01 Clinical Trial Not Allowed)?
National Institutes of Health accepted applications from nonprofits, colleges and universities, state and local governments, tribes, small businesses and businesses. The notice adds further conditions, so read its eligibility section.
What is the deadline for Transformative Nucleic Acid Sequencing Technology Innovation and Early Development (R01 Clinical Trial Not Allowed)?
Closed February 1, 2023. Applications are no longer accepted; the program's newer notices are on this page when there are any.
Who has been funded under RFA-HG-21-006?
NIH RePORTER lists 5 projects funded under RFA-HG-21-006 in fiscal 2022 to 2026, at 4 institutions. The most were at Northeastern University, State University of New York at Albany, Thomas Jefferson University.
Who has won Human Genome Research grants before?
The largest recipients over five fiscal years were The Leland Stanford Junior University, University of Washington, The Broad Institute, Inc. The program made 1,255 awards worth $2.2 billion in that time.
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