RFA-ES-23-001: Limited Competition: Superfund Hazardous Substance Research and Training Program (P42 Clinical Trial Optional)
Closed
This grant is closed. A newer notice from the same program is open now: Limited Competition: Superfund Hazardous Substance Research and Training Program (P42 Clinical Trial Optional) (RFA-ES-27-004). Status: Closes September 25, 2028 (688 days left). It is in our archive of National Institutes of Health notices from 2023.
National Institutes of Health offered grants of up to $2.0 million to colleges and universities. Applications closed on October 2, 2023.
From the official notice on Grants.gov, last changed April 18, 2023. Checked November 7, 2026.
- Award ceiling$2.0 million
- Cost sharingNot required
- Funding typeGrant
About this NIH notice
- Activity codeP42
- Clinical trialsOptional
- Funded byNIEHS
- Median yearly award$298,483
- Typical project length9.5 years
Projects funded under RFA-ES-23-001 were run by National Institute of Environmental Health Sciences (NIEHS, 8 projects). Contact the program officer at the institute that fits your project before you apply; the notice lists them.
Application due dates, page limits and budget limits are set in the notice. Read RFA-ES-23-001 in the NIH Guide.
Other notices with this title
| Notice | Posted | Deadline | Status |
|---|---|---|---|
| RFA-ES-27-004 | May 19, 2026 | Closes September 25, 2028 (688 days left) | Open |
Key dates
| Posted | April 17, 2023 |
|---|---|
| Deadline | October 2, 2023 |
| Archived by Grants.gov | November 7, 2023 |
Who can apply
This opportunity was open to colleges and universities.
- Public and State controlled institutions of higher education
- Private institutions of higher education
- Others (see text field entitled "Additional Information on Eligibility" for clarification)
Other Eligible Applicants include the following: Alaska Native and Native Hawaiian Serving Institutions; Asian American Native American Pacific Islander Serving Institutions (AANAPISISs); Hispanic-serving Institutions; Historically Black Colleges and Universities (HBCUs); Tribally Controlled Colleges and Universities (TCCUs) ; Non-domestic (non-U.S.) Entities (Foreign Institutions) are not eligible to apply. Non-domestic (non-U.S.) components of U.S. Organizations are not eligible to apply. Foreign components, as defined in the NIH Grants Policy Statement, are allowed.
Is this a realistic fit?
- Projects NIH funded under this notice had a median yearly award of $298,483; it allows up to $2.0 million per award.
- Most of the program's money (89% over five years) went to colleges and universities.
- No cost sharing or match is required.
What the grant funds
The National Institute of Environmental Health Sciences (NIEHS) is announcing the continuation of the Superfund Hazardous Substance Research and Training Program, referred to as Superfund Research Program (SRP) Centers. SRP Center grants will support problem-based, solution-oriented research Centers that consist of multiple, integrated projects representing both the biomedical and environmental science and engineering disciplines; as well as cores tasked with administrative (which includes research translation), data management and analysis, community engagement, research experience and training coordination, and research support functions. The scope of the SRP Centers is taken directly from the Superfund Amendments and Reauthorization Act of 1986, and includes: (1) advanced techniques for the detection, assessment, and evaluation of the effect on human health of hazardous substances; (2) methods to assess the risks to human health presented by hazardous substances; (3) methods and technologies to detect hazardous substances in the environment; and (4) basic biological, chemical, and physical methods to reduce the amount and toxicity of hazardous substances.
Funded under RFA-ES-23-001 so far
NIH funded 8 projects under RFA-ES-23-001 in fiscal 2025 to 2026, at 8 institutions. The median yearly award was $298,483.
| Project | Institution | Fiscal year | Award |
|---|---|---|---|
| Community Engagement Core | University of Iowa | 2026 | $174,762 |
| Administrative Core | Oregon State University | 2026 | $213,215 |
| Preconception iAs exposure: diabetes and epigenetic inheritance | Univ of North Carolina Chapel Hill | 2026 | $570,766 |
| Research Project 2: PFAS and Liver Health in Latino Youth: A Longitudinal Multi-Omics Study | University of Southern California | 2026 | $408,733 |
| Community Engagement Core | University of Arizona | 2026 | $184,226 |
| Animal models of cardiotoxicity to toxaphene | Emory University | 2026 | $208,985 |
| POLYCYCLIC AROMATIC HYDROCARBONS: ULTRASENSITIVE DETECTION,EARLY LIFE EXPOSURES-CLINICAL OUTCOMES (PRETERM BIRTHS, CHRONICLUNG DISEASE, AND NEUROCOGNITIVE DEFICITS), PREVENTION ANDREMEDIATION | Baylor College of Medicine | 2026 | $3.0 million |
| Metabolic impacts of PFAS exposure in the Cape Fear Basin: GenX Exposure Study | North Carolina State University Raleigh | 2026 | $4.2 million |
Who has won NIEHS Superfund Hazardous Substances_Basic Research and Education grants before
From fiscal 2021 to 2025, NIEHS Superfund Hazardous Substances_Basic Research and Education (93.143) awarded $250 million across 90 grant awards, an average of $2.8 million per award.
| Recipient | State | Awards | Amount |
|---|---|---|---|
| Oregon State University | Oregon | 2 | $14.3 million |
| The University of Iowa | Iowa | 2 | $12.9 million |
| University of North Carolina at Chapel Hill | North Carolina | 1 | $12.4 million |
| University of Louisville | Kentucky | 1 | $12.3 million |
| Duke University | North Carolina | 3 | $12.2 million |
Applying now
This notice no longer takes applications. Apply under the newer notice, RFA-ES-27-004, which is open now.
The notice on Grants.gov keeps its full text and attachments, which is useful for planning a resubmission.
Questions people ask
Is RFA-ES-23-001 still open?
No. It closed on October 2, 2023. A newer notice is open: RFA-ES-27-004, closes September 25, 2028 (688 days left).
Who can apply for Limited Competition: Superfund Hazardous Substance Research and Training Program (P42 Clinical Trial Optional)?
National Institutes of Health accepted applications from colleges and universities. The notice adds further conditions, so read its eligibility section.
What is the deadline for Limited Competition: Superfund Hazardous Substance Research and Training Program (P42 Clinical Trial Optional)?
Closed October 2, 2023. Applications are no longer accepted; the program's newer notices are on this page when there are any.
How much funding is available?
Awards of up to $2.0 million each.
Who has been funded under RFA-ES-23-001?
NIH RePORTER lists 8 projects funded under RFA-ES-23-001 in fiscal 2025 to 2026, at 8 institutions. The most were at University of Iowa, Oregon State University, Univ of North Carolina Chapel Hill.
Who has won NIEHS Superfund Hazardous Substances_Basic Research and Education grants before?
The largest recipients over five fiscal years were Oregon State University, The University of Iowa, University of North Carolina at Chapel Hill. The program made 90 awards worth $250 million in that time.
Similar open grants
- Limited Competition: Superfund Hazardous Substance Research and Training Program (P42 Clinical Trial Optional)
- Single Source for the Continuation of the Caring for OutPatiEnts after Acute Kidney Injury (COPE-AKI) Scientific and Data Research Center (U01 Clinical Trial Required)
- Single Source for the Continuation of the Epidemiology of Diabetes Interventions and Complications (EDIC) Study Research Center (Collaborative U01 Clinical Trial Not Allowed)
- Fiscal Year (FY) 2026 Funding Opportunity for Indian Tribes and Intertribal Consortia for Nonpoint Source Management Grants Under Clean Water Act Section 319
- Data Coordinating Center for the Aging and Alzheimer’s Disease Mouse Brain Atlas (AD-MBA) (U24 Clinical Trial Not Allowed)
- Amyotrophic Lateral Sclerosis (ALS) Intermediate Patient Population Expanded Access (U01 Clinical Trial Required)