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Grants / Department of Health and Human Services / National Institutes of Health

Limited Competition: Superfund Hazardous Substance Research and Training Program (P42 Clinical Trial Optional)

Open Closes September 25, 2028 (695 days left) Opportunity RFA-ES-27-004

National Institutes of Health is offering grants of up to $1.8 million to colleges and universities. It expects to make about 10 awards worth $22.0 million in total. Applications close on September 25, 2028.

From the official notice on Grants.gov, last changed May 19, 2026. Checked October 31, 2026.

Key dates

PostedMay 19, 2026
DeadlineSeptember 25, 2028
Archived by Grants.govNovember 24, 2028

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Who can apply

This opportunity is open to colleges and universities.

Based on 42 USC 9660(a)(3) eligible applicants are limited to accredited institutes of higher education. Eligible applicants are permitted under the law, and encouraged by NIEHS, to subcontract as appropriate with other organizations as necessary to conduct portions of the research. Examples of other organizations may include generators of hazardous wastes; persons involved in the detection, assessment, evaluation, and treatment of hazardous substances; owners and operators of facilities at which hazardous substances are located; and/or State and local governments. Refer to Section III. Eligibility Information in the NOFO for additional information on eligibility. Foreign Organizations/International Collaborations:Non-domestic (non-U.S.) Entities (Foreign Organization) are not eligible to apply. Non-domestic (non-U.S.) components of U.S. Organizations are not eligible to apply. Foreign components, as defined in the NIH Grants Policy Statement, are not allowed.

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Is this a realistic fit?

What the grant funds

The National Institute of Environmental Health Sciences (NIEHS) is announcing the continuation of the Superfund Hazardous Substance Research and Training Program, referred to as Superfund Research Program (SRP) Centers. SRP Center grants will support problem-based, solution-oriented research Centers that consist of multiple, integrated projects representing both the biomedical and environmental science and engineering disciplines; as well as cores tasked with administrative (which includes Center leadership, data management, and training); translational research and engagement; and research support functions. The scope of the SRP Centers is taken directly from the Superfund Amendments and Reauthorization Act of 1986, which limits competition for this program to accredited institutes of higher education. Please see Section III. Eligibility for additional information. In accordance with NIH standard peer-review processes, the application(s) will be peer-reviewed, and only meritorious application(s) will be considered for funding.

Category: Health.

How to apply

  1. Read the full notice and attachments on Grants.gov. The notice is the official source for deadlines and requirements.
  2. Make sure your organization has an active SAM.gov registration and Unique Entity ID; registration can take several weeks.
  3. Register on Grants.gov and submit through Workspace before the deadline and time given in the notice. Our application guide walks through each step.

Questions go to National Institutes of Health, 301-402-2541.

Open the official notice

Questions people ask

Who can apply for Limited Competition: Superfund Hazardous Substance Research and Training Program (P42 Clinical Trial Optional)?

National Institutes of Health accepts applications from colleges and universities. The notice adds further conditions, so read its eligibility section.

What is the deadline for Limited Competition: Superfund Hazardous Substance Research and Training Program (P42 Clinical Trial Optional)?

Closes September 25, 2028 (695 days left). Confirm the date and time in the official notice on Grants.gov.

How much funding is available?

Awards of up to $1.8 million each. About $22.0 million in total across about 10 awards.

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