Well Told Grants

Grants / Department of Health and Human Services / National Institutes of Health

RFA-ES-22-009: Biological Basis for how Environmental Exposures Impact Risk for Psychiatric Disorders (R21 Clinical Trial Not Allowed)

Closed Closed February 22, 2023 Opportunity RFA-ES-22-009

This grant is closed. Who won this program's grants before is below, and similar open grants are at the end of the page. It is in our archive of National Institutes of Health notices from 2022.

National Institutes of Health offered grants of up to $275,000 to nonprofits, colleges and universities, state and local governments, tribes, small businesses and businesses. Applications closed on February 22, 2023.

From the official notice on Grants.gov, last changed October 3, 2022. Checked November 7, 2026.

About this NIH notice

Projects funded under RFA-ES-22-009 were run by National Institute of Environmental Health Sciences (NIEHS, 4 projects). Contact the program officer at the institute that fits your project before you apply; the notice lists them.

Application due dates, page limits and budget limits are set in the notice. Read RFA-ES-22-009 in the NIH Guide.

Key dates

PostedOctober 3, 2022
DeadlineFebruary 22, 2023
Archived by Grants.govMarch 30, 2023

Who can apply

This opportunity was open to nonprofits, colleges and universities, state and local governments, tribes, small businesses and businesses.

All 15 applicant types the notice lists

Other Eligible Applicants include the following: Alaska Native and Native Hawaiian Serving Institutions; Asian American Native American Pacific Islander Serving Institutions (AANAPISISs); Eligible Agencies of the Federal Government; Faith-based or Community-based Organizations; Hispanic-serving Institutions; Historically Black Colleges and Universities (HBCUs); Indian/Native American Tribal Governments (Other than Federally Recognized); Non-domestic (non-U.S.) Entities (Foreign Organizations); Regional Organizations; Tribally Controlled Colleges and Universities (TCCUs) ; U.S. Territory or Possession; Non-domestic (non-U.S.) Entities (Foreign Institutions) are not eligible to apply. Non-domestic (non-U.S.) components of U.S. Organizations are not eligible to apply. Foreign components, as defined in the NIH Grants Policy Statement, are allowed.

More grants for nonprofits, colleges and universities, state and local governments, tribes, small businesses, businesses.

Is this a realistic fit?

What the grant funds

The objective of this funding opportunity announcement (FOA) is to solicit applications that propose to better understand the biological basis by which environmental exposures alter brain and behavioral functioning to increase risk for psychiatric disorders with onset in late-childhood, adolescence, or early adulthood. The R21 grant mechanism is intended to encourage exploratory and developmental research projects that are high-risk and/or use novel approaches with potential for significant impact. Investigations that further advance our understanding of psychiatric conditions where there is less evidence of an environmental exposure link are of particular interest. Since basic and pre-clinical research is critical for the study of neurobiological mechanisms that drive complex behaviors including mental illness, the focus of this FOA is to encourage a range of mechanistic approaches, from in vitro systems to whole organism models, to examine the link between environmental chemicals and possible contribution to the pathogenesis of psychiatric abnormalities. Investigations that further advance our understanding of the joint contribution of genes and environment in the risk for psychiatric disorders are also welcomed. It is anticipated that knowledge gained from the research supported by this FOA will inform the development of improved intervention, prevention and/or therapeutic strategies. This FOA will use the NIH Exploratory/Developmental Research Grant (R21) award mechanism and runs in parallel with another FOA, RFA-ES-22-008, which encourages applications under the R01 mechanism.

Category: Environment, Health.

Funded under RFA-ES-22-009 so far

NIH funded 4 projects under RFA-ES-22-009 in fiscal 2024 to 2025, at 4 institutions. The median yearly award was $197,694.

From NIH RePORTER, which lists each project once per fiscal year it was funded. Amounts are the yearly award.

Who has won Environmental Health grants before

From fiscal 2021 to 2025, Environmental Health (93.113) awarded $2.1 billion across 1,980 grant awards, an average of $1.1 million per award.

Largest recipients, fiscal 2021 to 2025
RecipientStateAwardsAmount
Icahn School of Medicine at Mount SinaiNew York49$87.7 million
The Trustees of Columbia University in the City of New YorkNew York69$78.7 million
University of North Carolina at Chapel HillNorth Carolina59$71.5 million
Emory UniversityGeorgia57$67.2 million
University of Southern CaliforniaCalifornia40$58.9 million

Top states: New York ($315 million), California ($269 million), North Carolina ($175 million), Massachusetts ($166 million), Michigan ($108 million).

Applying now

This notice no longer takes applications. Agencies often post the same opportunity again under a new number, so check the program's notices on Grants.gov and the similar open grants below.

The notice on Grants.gov keeps its full text and attachments, which is useful for planning a resubmission.

Questions people ask

Is RFA-ES-22-009 still open?

No. It closed on February 22, 2023.

Who can apply for Biological Basis for how Environmental Exposures Impact Risk for Psychiatric Disorders (R21 Clinical Trial Not Allowed)?

National Institutes of Health accepted applications from nonprofits, colleges and universities, state and local governments, tribes, small businesses and businesses. The notice adds further conditions, so read its eligibility section.

What is the deadline for Biological Basis for how Environmental Exposures Impact Risk for Psychiatric Disorders (R21 Clinical Trial Not Allowed)?

Closed February 22, 2023. Applications are no longer accepted; the program's newer notices are on this page when there are any.

How much funding is available?

Awards of up to $275,000 each.

Who has been funded under RFA-ES-22-009?

NIH RePORTER lists 4 projects funded under RFA-ES-22-009 in fiscal 2024 to 2025, at 4 institutions. The most were at University of Colorado, Mount Desert Island Biological Lab, Rutgers Biomedical and Health Sciences.

Who has won Environmental Health grants before?

The largest recipients over five fiscal years were Icahn School of Medicine at Mount Sinai, The Trustees of Columbia University in the City of New York, University of North Carolina at Chapel Hill. The program made 1,980 awards worth $2.1 billion in that time.

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