RFA-ES-22-002: Revolutionizing Innovative, Visionary Environmental Health Research (RIVER) (R35 Clinical Trial Optional)
Closed
This grant is closed. Who won this program's grants before is below, and similar open grants are at the end of the page. It is in our archive of National Institutes of Health notices from 2022.
National Institutes of Health offered grants to nonprofits, colleges and universities, state and local governments, tribes, small businesses and businesses. Applications closed on June 9, 2022.
From the official notice on Grants.gov, last changed January 21, 2022. Checked November 7, 2026.
- Award amountsNot given on Grants.gov
- Cost sharingNot required
- Funding typeGrant
About this NIH notice
- Activity codeR35
- Clinical trialsOptional
- Funded byNIEHS
- Median yearly award$934,422
- Typical project length8 years
- R35, Outstanding Investigator Award. Support for an investigator's whole research program rather than a single project (this includes MIRA awards). Other open R35 notices.
Projects funded under RFA-ES-22-002 were run by National Institute of Environmental Health Sciences (NIEHS, 5 projects). Contact the program officer at the institute that fits your project before you apply; the notice lists them.
Application due dates, page limits and budget limits are set in the notice. Read RFA-ES-22-002 in the NIH Guide.
Other notices with this title
| Notice | Posted | Deadline | Status |
|---|---|---|---|
| RFA-ES-24-004 | July 26, 2024 | Closed November 1, 2024 | Closed |
Key dates
| Posted | January 21, 2022 |
|---|---|
| Deadline | June 9, 2022 |
| Archived by Grants.gov | July 15, 2022 |
Who can apply
This opportunity was open to nonprofits, colleges and universities, state and local governments, tribes, small businesses and businesses.
All 15 applicant types the notice lists
- State governments
- County governments
- City or township governments
- Special district governments
- Independent school districts
- Public and State controlled institutions of higher education
- Native American tribal governments (Federally recognized)
- Public housing authorities/Indian housing authorities
- Native American tribal organizations (other than Federally recognized tribal governments)
- Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education
- Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education
- Private institutions of higher education
- For profit organizations other than small businesses
- Small businesses
- Others (see text field entitled "Additional Information on Eligibility" for clarification)
Other Eligible Applicants include the following: Alaska Native and Native Hawaiian Serving Institutions; Asian American Native American Pacific Islander Serving Institutions (AANAPISISs); Eligible Agencies of the Federal Government; Faith-based or Community-based Organizations; Hispanic-serving Institutions; Historically Black Colleges and Universities (HBCUs); Indian/Native American Tribal Governments (Other than Federally Recognized); Non-domestic (non-U.S.) Entities (Foreign Organizations); Regional Organizations; Tribally Controlled Colleges and Universities (TCCUs) ; U.S. Territory or Possession; Non-domestic (non-U.S.) Entities (Foreign Institutions) are not eligible to apply. Non-domestic (non-U.S.) components of U.S. Organizations are not eligible to apply. Foreign components, as defined in the NIH Grants Policy Statement, are allowed.
Is this a realistic fit?
- Most of the program's money (81% over five years) went to colleges and universities.
- No cost sharing or match is required.
What the grant funds
The NIEHS Revolutionizing Innovative, Visionary Environmental health Research (RIVER) program is intended to provide support for outstanding investigators in the Environmental Health Sciences, giving them intellectual and administrative freedom, as well as sustained support to pursue their research in novel directions in order to achieve greater impacts. The program seeks to identify individuals, regardless of career stage, with a potential for continued innovative and impactful research and combine their existing investigator-initiated research into a single award to support the majority of their independent environmental health sciences research program.
Funded under RFA-ES-22-002 so far
NIH funded 5 projects under RFA-ES-22-002 in fiscal 2023 to 2026, at 5 institutions. The median yearly award was $934,422.
| Project | Institution | Fiscal year | Award |
|---|---|---|---|
| Epitranscriptomic mechanism of environmental stress response and tumorigenesis | University of Chicago | 2026 | $1.2 million |
| Environmental Chemical Impact on the Host-Microbiome Interaction | The Pennsylvania State University | 2026 | $885,585 |
| Deciphering innate immune signaling mechanisms in glial cells linking lifetime environmental exposures to neuroinflammation, protein aggregation and neurodegeneration in Parkinsons disease | Colorado State University | 2026 | $1.1 million |
| Environmental Epigenetics of EDCs: From Germline to Brain | University of Texas at Austin | 2026 | $937,358 |
| Role of PXR in EDC-induced cardiovascular disease | University of California Riverside | 2026 | $838,201 |
Who has won Environmental Health grants before
From fiscal 2021 to 2025, Environmental Health (93.113) awarded $2.1 billion across 1,980 grant awards, an average of $1.1 million per award.
| Recipient | State | Awards | Amount |
|---|---|---|---|
| Icahn School of Medicine at Mount Sinai | New York | 49 | $87.7 million |
| The Trustees of Columbia University in the City of New York | New York | 69 | $78.7 million |
| University of North Carolina at Chapel Hill | North Carolina | 59 | $71.5 million |
| Emory University | Georgia | 57 | $67.2 million |
| University of Southern California | California | 40 | $58.9 million |
Applying now
This notice no longer takes applications. Agencies often post the same opportunity again under a new number, so check the program's notices on Grants.gov and the similar open grants below.
The notice on Grants.gov keeps its full text and attachments, which is useful for planning a resubmission.
Questions people ask
Is RFA-ES-22-002 still open?
No. It closed on June 9, 2022.
Who can apply for Revolutionizing Innovative, Visionary Environmental Health Research (RIVER) (R35 Clinical Trial Optional)?
National Institutes of Health accepted applications from nonprofits, colleges and universities, state and local governments, tribes, small businesses and businesses. The notice adds further conditions, so read its eligibility section.
What is the deadline for Revolutionizing Innovative, Visionary Environmental Health Research (RIVER) (R35 Clinical Trial Optional)?
Closed June 9, 2022. Applications are no longer accepted; the program's newer notices are on this page when there are any.
Who has been funded under RFA-ES-22-002?
NIH RePORTER lists 5 projects funded under RFA-ES-22-002 in fiscal 2023 to 2026, at 5 institutions. The most were at University of Chicago, The Pennsylvania State University, Colorado State University.
Who has won Environmental Health grants before?
The largest recipients over five fiscal years were Icahn School of Medicine at Mount Sinai, The Trustees of Columbia University in the City of New York, University of North Carolina at Chapel Hill. The program made 1,980 awards worth $2.1 billion in that time.
Similar open grants
- NHLBI Outstanding Investigator Award (OIA) (R35 Clinical Trial Optional)
- NHLBI Emerging Investigator Award (EIA) (R35 Clinical Trial Optional)
- Change of Recipient Organization (Type 7 Parent Clinical Trial Optional)
- Investigator-Focused Award (Parent R35)
- Maximizing Investigators' Research Award (MIRA) (R35 - Clinical Trial Optional)
- Administrative Supplements to Existing NIH Grants and Cooperative Agreements (Parent Admin Supp Clinical Trial Optional)