Grants / Department of Health and Human Services / Centers for Disease Control and Prevention - ERA

RFA-DP-25-038: Epilepsy Incidence Among Children in the United States

Closed Closed January 23, 2025 Opportunity RFA-DP-25-038 ☆ Save

This grant is closed. A newer notice from the same program is open now: NIH, CDC and FDA Small Business Innovation Research Grant (Parent SBIR [R43/R44] Clinical Trial Optional) (PA-27-100). Status: Due dates in the notice, expires April 5, 2027. It is in our archive of Centers for Disease Control and Prevention - ERA notices from 2024.

• Award ceiling$500,000
• Total funding$1.6 million
• Expected awards1
• Cost sharingNot required
• Funding typeCooperative Agreement

Key dates

Who can apply

This opportunity was open to nonprofits, colleges and universities, state and local governments, tribes, small businesses and businesses.

N/A

More grants for nonprofits, colleges and universities, state and local governments, tribes, small businesses, businesses.

Is this a realistic fit?

• Past Chronic Diseases: Research, Control, and Prevention awards averaged $651,162; this notice allows up to $500,000 per award.
• Most of the program's money (35% over five years) went to nonprofits.
• No cost sharing or match is required.

What the grant funds

Few population-based epilepsy incidence studies among children in the United States exist, and these studies are limited to specific geographic areas with small sample sizes. Studies which used nationwide administrative and claims data to estimate epilepsy incidence among children were conducted more than a decade ago and failed to provide national generalizability due to their limited data sources. This NOFO will contribute to a comprehensive understanding of epilepsy incidence (any type), incident-related risk factors, and incidence disparities among the general U.S. pediatric population or subpopulations. The knowledge obtained from this study will assist health officials shape public health policies by allocating resources, planning for healthcare services, and implementing preventive measures. The objectives of the NOFO are to: (1) Estimate epilepsy incidence among U.S. children 0 - 17 years of age based upon a study with comprehensive nationwide dataset(s), or a population-based study at a specific level(s) (e.g., national, regional, jurisdictional); (2) Identify factors that contribute to the risk of developing epilepsy, and examine the association between these risk factors and incidence; and (3) Examine potential disparities in incidence rates of epilepsy stratified by demographic, geographical, the social determinants of health (SDOH), or other characteristics. The target population is for U.S. children aged 0 - 17 years, and for the study of certain epilepsies, some age ranges within 0 - 17 years are acceptable. Additionally, this study should include a nationally representative sample of age, sex, race/ethnicity, and social strata, and include subgroups which allow an examination of risk factors and SDOH. The applicant is expected to: (1) Conduct a retrospective study using public/commercial administrative and/or claims data, electronic health records, or survey data; (2) Ensure dataset(s) have sufficient sample sizes relative to risk factors, allowing incidence rates to be stratified by these factors. If public/commercial claims data or survey data are used, it should include child populations from all states and Washington DC. Examples of claims data are Marketscan and Medicaid. If EHR data are used, adequate details/justification must be included; (3) Identify risk factors based on the literature.

Category: Health.

Applying now

This notice no longer takes applications. Apply under the newer notice, PA-27-100, which is open now.

The notice on Grants.gov keeps its full text and attachments, which is useful for planning a resubmission.