RFA-DA-25-050: Solutions to enable diagnosis and treatment of adverse health consequences of non-disordered drug use (R43/R44 - Clinical Trial Optional)
Closed
This grant is closed. Who won this program's grants before is below, and similar open grants are at the end of the page. It is in our archive of National Institutes of Health notices from 2024.
National Institutes of Health offered grants to small businesses. Applications closed on December 2, 2024.
From the official notice on Grants.gov, last changed June 13, 2024. Checked November 7, 2026.
- Award amountsNot given on Grants.gov
- Cost sharingNot required
- Funding typeGrant
About this NIH notice
- Activity codeR43 / R44
- Clinical trialsOptional
- Funded byNIDA
- Median yearly award$399,998
- Typical project length1 year
- R43, Small Business Innovation Research (SBIR) Phase I. A small business tests the feasibility of a technology or product. Other open R43 notices.
- R44, Small Business Innovation Research (SBIR) Phase II. Full research and development of an SBIR project after Phase I (or both phases at once, called Fast Track). Other open R44 notices.
Projects funded under RFA-DA-25-050 were run by National Institute on Drug Abuse (NIDA, 4 projects). Contact the program officer at the institute that fits your project before you apply; the notice lists them.
Application due dates, page limits and budget limits are set in the notice. Read RFA-DA-25-050 in the NIH Guide.
Key dates
| Posted | June 13, 2024 |
|---|---|
| Deadline | December 2, 2024 |
| Archived by Grants.gov | January 7, 2025 |
Who can apply
This opportunity was open to small businesses.
- Small businesses
Other Eligible Applicants include the following: Non-domestic (non-U.S.) Entities (Foreign Organizations) are not eligible to apply. Non-domestic (non-U.S.) components of U.S. Organizations are not eligible to apply. Foreign components, as defined in the NIH Grants Policy Statement, may be allowed.
Is this a realistic fit?
- Most of the program's money (70% over five years) went to colleges and universities.
- No cost sharing or match is required.
What the grant funds
This notice of funding opportunity (NOFO) encourages Small Business Innovation Research (SBIR) grants applications from small business concerns (SBC) proposing research and development of solutions targeted to improve health outcomes and reduce the impact of adverse health consequences of non-disordered drug use. Solutions could be based on original technologies or existing technologies already avaialble that could be repurposed to target the specific needs of people who use drugs. Proposed solutions should emphasize accessibility and affordability and be designed to be implemented in healthcare services.
Funded under RFA-DA-25-050 so far
NIH funded 4 projects under RFA-DA-25-050 in fiscal 2025 to 2026, at 4 institutions. The median yearly award was $399,998.
| Project | Institution | Fiscal year | Award |
|---|---|---|---|
| A digital platform to address adverse effects resulting from non-disordered drug use, focused on mitigating serious mental illness | Doro Mind Inc. | 2026 | $398,580 |
| SmartDrive: AI-Powered Mobile App for Real-Time Detection of Non-Disordered Drug Use in Drivers | Tibbling Technologies LLC | 2026 | $400,000 |
| Device-Agnostic Hypoxia Detection Software for Overdose Prediction and Positive Reversal Monitoring | Altrumed LLC | 2025 | $404,078 |
| Neural exosome therapeutics for treating opioid-induced brain hypoxia injuries | Aruna Biomedical, Inc. | 2025 | $399,997 |
Who has won Drug Use and Addiction Research Programs grants before
From fiscal 2021 to 2025, Drug Use and Addiction Research Programs (93.279) awarded $7.3 billion across 5,071 grant awards, an average of $1.4 million per award.
| Recipient | State | Awards | Amount |
|---|---|---|---|
| Yale Univ | Connecticut | 150 | $305 million |
| The Johns Hopkins University | Maryland | 156 | $262 million |
| University of California, San Diego | California | 120 | $242 million |
| University of Pittsburgh - of the Commonwealth System of Higher Education | Pennsylvania | 100 | $182 million |
| New York University | New York | 62 | $173 million |
Applying now
This notice no longer takes applications. Agencies often post the same opportunity again under a new number, so check the program's notices on Grants.gov and the similar open grants below.
The notice on Grants.gov keeps its full text and attachments, which is useful for planning a resubmission.
Questions people ask
Is RFA-DA-25-050 still open?
No. It closed on December 2, 2024.
Who can apply for Solutions to enable diagnosis and treatment of adverse health consequences of non-disordered drug use (R43/R44 - Clinical Trial Optional)?
National Institutes of Health accepted applications from small businesses. The notice adds further conditions, so read its eligibility section.
What is the deadline for Solutions to enable diagnosis and treatment of adverse health consequences of non-disordered drug use (R43/R44 - Clinical Trial Optional)?
Closed December 2, 2024. Applications are no longer accepted; the program's newer notices are on this page when there are any.
Who has been funded under RFA-DA-25-050?
NIH RePORTER lists 4 projects funded under RFA-DA-25-050 in fiscal 2025 to 2026, at 4 institutions. The most were at Doro Mind Inc., Tibbling Technologies LLC, Altrumed LLC.
Who has won Drug Use and Addiction Research Programs grants before?
The largest recipients over five fiscal years were Yale Univ, The Johns Hopkins University, University of California, San Diego. The program made 5,071 awards worth $7.3 billion in that time.
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- Successor-in-Interest (Type 6 Parent Clinical Trial Optional)
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