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Grants / Department of Health and Human Services / Centers for Disease Control and Prevention - ERA

RFA-CE-25-149: Rigorous Evaluation of Primary and Secondary Overdose Prevention Activities Among Populations Disproportionately Affected by Overdose

Closed Closed December 2, 2024 Opportunity RFA-CE-25-149

This grant is closed. A newer notice from the same program is open now: NIH, CDC and FDA Small Business Innovation Research Grant (Parent SBIR [R43/R44] Clinical Trial Optional) (PA-27-100). Status: Due dates in the notice, expires April 5, 2027. It is in our archive of Centers for Disease Control and Prevention - ERA notices from 2024.

Centers for Disease Control and Prevention - ERA offered grants of up to $700,000 to any type of organization. It expected to make about 7 awards worth $4.9 million in total. Applications closed on December 2, 2024.

From the official notice on Grants.gov, last changed November 8, 2024. Checked November 7, 2026.

Key dates

PostedAugust 30, 2024
DeadlineDecember 2, 2024
Archived by Grants.govMarch 9, 2025

Who can apply

This opportunity was open to any type of organization.

All 16 applicant types the notice lists

The following types of Higher Education Institutions are encouraged to apply for CDC support as Public or Private Institutions of Higher Education: Hispanic-serving Institutions; Historically Black Colleges and Universities (HBCUs); Tribally Controlled Colleges and Universities (TCCUs); Alaska Native and Native Hawaiian Serving Institutions; Nonprofits (Other than Institutions of Higher Education); Faith-based or Community-based Organizations; Regional Organizations; Bona Fide Agents: A Bona Fide Agent is an agency/organization identified by the state as eligible to submit an application under the state eligibility in lieu of a state application. If applying as a bona fide agent of a state or local government, a legal, binding agreement from the state or local government as documentation of the status is required. Attach with “Other Attachment Forms;” Federally Funded Research and Development Centers (FFRDCs): FFRDCs are operated, managed, and/or administered by a university or consortium of universities, other not-for-profit or nonprofit organization, or an industrial firm, as an autonomous organization or as an identifiable separate operating unit of a parent organization. A FFRDC meets some special long-term research or development need which cannot be met as effectively by an agency's existing in-house or contractor resources. FFRDC's enable agencies to use private sector resources to accomplish tasks that are integral to the mission and operation of the sponsoring agency. For more information on FFRDCs, go to https://gov.ecfr.io/cgi-bin/searchECFR.

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Is this a realistic fit?

What the grant funds

This NOFO funds research focused on people experiencing disproportionate burden of drug overdose, those who are at greater risk of exposure to drug use, or those experiencing adverse drug use outcomes related to social determinants of health. Your research should rigorously evaluate either primary or secondary prevention strategies for reducing rates of nonfatal overdose, fatal overdose, and/or substance use disorders involving federally illegal drugs or misuse of prescription medications, drug use, or initiation of drug use, particularly among youth.

Category: Health.

Who has won Injury Prevention and Control Research and State and Community Based Programs grants before

From fiscal 2021 to 2025, Injury Prevention and Control Research and State and Community Based Programs (93.136) awarded $2.2 billion across 986 grant awards, an average of $2.2 million per award.

Largest recipients, fiscal 2021 to 2025
RecipientStateAwardsAmount
Florida Department of HealthFlorida12$81.1 million
California Department of Public HealthCalifornia11$55.4 million
Ohio Department of HealthOhio9$42.0 million
North Carolina Department of Health & Human ServicesNorth Carolina12$42.0 million
Michigan Department of Health and Human ServicesMichigan10$37.9 million

Top states: California ($127 million), Pennsylvania ($106 million), Ohio ($105 million), Georgia ($102 million), Florida ($84.6 million).

Applying now

This notice no longer takes applications. Apply under the newer notice, PA-27-100, which is open now.

The notice on Grants.gov keeps its full text and attachments, which is useful for planning a resubmission.

Questions people ask

Is RFA-CE-25-149 still open?

No. It closed on December 2, 2024. A newer notice is open: PA-27-100, due dates in the notice, expires April 5, 2027.

Who can apply for Rigorous Evaluation of Primary and Secondary Overdose Prevention Activities Among Populations Disproportionately Affected by Overdose?

Centers for Disease Control and Prevention - ERA accepted applications from any type of organization. The notice adds further conditions, so read its eligibility section.

What is the deadline for Rigorous Evaluation of Primary and Secondary Overdose Prevention Activities Among Populations Disproportionately Affected by Overdose?

Closed December 2, 2024. Applications are no longer accepted; the program's newer notices are on this page when there are any.

How much funding is available?

Awards of up to $700,000 each. About $4.9 million in total across about 7 awards.

Who has won Injury Prevention and Control Research and State and Community Based Programs grants before?

The largest recipients over five fiscal years were Florida Department of Health, California Department of Public Health, Ohio Department of Health. The program made 986 awards worth $2.2 billion in that time.

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