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Grants / Department of Health and Human Services / Centers for Disease Control and Prevention - ERA

RFA-CE-22-011: Understanding Polydrug Use Risk and Protective Factors, Patterns, and Trajectories to Prevent Drug Overdose

Closed Closed February 24, 2022 Opportunity RFA-CE-22-011

This grant is closed. A newer notice from the same program is open now: NIH, CDC and FDA Small Business Innovation Research Grant (Parent SBIR [R43/R44] Clinical Trial Optional) (PA-27-100). Status: Due dates in the notice, expires April 5, 2027. It is in our archive of Centers for Disease Control and Prevention - ERA notices from 2021.

Centers for Disease Control and Prevention - ERA offered grants of up to $350,000 to any type of organization. It expected to make about 5 awards worth $5.3 million in total. Applications closed on February 24, 2022.

From the official notice on Grants.gov, last changed January 14, 2022. Checked November 7, 2026.

Key dates

PostedDecember 8, 2021
DeadlineFebruary 24, 2022
Archived by Grants.govMarch 26, 2022

Who can apply

This opportunity was open to any type of organization.

All 16 applicant types the notice lists

See Section III. Eligibility Information

More grants for nonprofits, colleges and universities, state and local governments, tribes, small businesses, businesses, individuals.

Is this a realistic fit?

What the grant funds

The Centers for Disease Control and Prevention (CDC) National Centers for Injury Prevention and Control (NCIPC) is soliciting investigator initiated research to improve our understanding of risk and protective factors, patterns, and trajectories related to polydrug use, with a focus on polydrug combinations most likely to result in nonfatal overdose or death, such as combinations including synthetic opioids. Polydrug combinations of interest include the following: Co-use of multiple opioids, knowingly or unknowingly (i.e., due to unknown adulterants) Co-use of non-opioid drugs (particularly psychostimulants [e.g., methamphetamine], cocaine, and benzodiazepines) AND opioids, knowingly or unknowingly Co-use of other combinations of drugs that may result in drug overdose Applicants should focus on identifying risk and protective factors, AND patterns, AND trajectories of polydrug use for either 1) the general population OR 2) one or more of the following subpopulations of interest: Persons who have experienced acute or chronic pain and used prescription opioids to manage their pain Persons who use cannabis, either medically or non-medically Applicants may also use prior research or preliminary data to justify an alternate subpopulation of interest, such as other groups which have been disproportionately affected by overdose. The overall goal of this research is to better understand risk and protective factors for and patterns and trajectories of polydrug use in order to inform targeted drug use and overdose prevention efforts.

Category: Health.

Who has won Injury Prevention and Control Research and State and Community Based Programs grants before

From fiscal 2021 to 2025, Injury Prevention and Control Research and State and Community Based Programs (93.136) awarded $2.2 billion across 986 grant awards, an average of $2.2 million per award.

Largest recipients, fiscal 2021 to 2025
RecipientStateAwardsAmount
Florida Department of HealthFlorida12$81.1 million
California Department of Public HealthCalifornia11$55.4 million
Ohio Department of HealthOhio9$42.0 million
North Carolina Department of Health & Human ServicesNorth Carolina12$42.0 million
Michigan Department of Health and Human ServicesMichigan10$37.9 million

Top states: California ($127 million), Pennsylvania ($106 million), Ohio ($105 million), Georgia ($102 million), Florida ($84.6 million).

Applying now

This notice no longer takes applications. Apply under the newer notice, PA-27-100, which is open now.

The notice on Grants.gov keeps its full text and attachments, which is useful for planning a resubmission.

Questions people ask

Is RFA-CE-22-011 still open?

No. It closed on February 24, 2022. A newer notice is open: PA-27-100, due dates in the notice, expires April 5, 2027.

Who can apply for Understanding Polydrug Use Risk and Protective Factors, Patterns, and Trajectories to Prevent Drug Overdose?

Centers for Disease Control and Prevention - ERA accepted applications from any type of organization. The notice adds further conditions, so read its eligibility section.

What is the deadline for Understanding Polydrug Use Risk and Protective Factors, Patterns, and Trajectories to Prevent Drug Overdose?

Closed February 24, 2022. Applications are no longer accepted; the program's newer notices are on this page when there are any.

How much funding is available?

Awards of up to $350,000 each. About $5.3 million in total across about 5 awards.

Who has won Injury Prevention and Control Research and State and Community Based Programs grants before?

The largest recipients over five fiscal years were Florida Department of Health, California Department of Public Health, Ohio Department of Health. The program made 986 awards worth $2.2 billion in that time.

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