RFA-CE-22-011: Understanding Polydrug Use Risk and Protective Factors, Patterns, and Trajectories to Prevent Drug Overdose
Closed
This grant is closed. A newer notice from the same program is open now: NIH, CDC and FDA Small Business Innovation Research Grant (Parent SBIR [R43/R44] Clinical Trial Optional) (PA-27-100). Status: Due dates in the notice, expires April 5, 2027. It is in our archive of Centers for Disease Control and Prevention - ERA notices from 2021.
Centers for Disease Control and Prevention - ERA offered grants of up to $350,000 to any type of organization. It expected to make about 5 awards worth $5.3 million in total. Applications closed on February 24, 2022.
From the official notice on Grants.gov, last changed January 14, 2022. Checked November 7, 2026.
- Award ceiling$350,000
- Total funding$5.3 million
- Expected awards5
- Cost sharingNot required
- Funding typeGrant
Key dates
| Posted | December 8, 2021 |
|---|---|
| Deadline | February 24, 2022 |
| Archived by Grants.gov | March 26, 2022 |
Who can apply
This opportunity was open to any type of organization.
All 16 applicant types the notice lists
- State governments
- County governments
- City or township governments
- Special district governments
- Independent school districts
- Public and State controlled institutions of higher education
- Native American tribal governments (Federally recognized)
- Public housing authorities/Indian housing authorities
- Native American tribal organizations (other than Federally recognized tribal governments)
- Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education
- Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education
- Private institutions of higher education
- For profit organizations other than small businesses
- Small businesses
- Others (see text field entitled "Additional Information on Eligibility" for clarification)
- Unrestricted (i.e., open to any type of entity above), subject to any clarification in text field entitled "Additional Information on Eligibility"
See Section III. Eligibility Information
Is this a realistic fit?
- Past Injury Prevention and Control Research and State and Community Based Programs awards averaged $2.2 million; this notice allows up to $350,000 per award.
- Most of the program's money (76% over five years) went to state and local governments.
- No cost sharing or match is required.
What the grant funds
The Centers for Disease Control and Prevention (CDC) National Centers for Injury Prevention and Control (NCIPC) is soliciting investigator initiated research to improve our understanding of risk and protective factors, patterns, and trajectories related to polydrug use, with a focus on polydrug combinations most likely to result in nonfatal overdose or death, such as combinations including synthetic opioids. Polydrug combinations of interest include the following: Co-use of multiple opioids, knowingly or unknowingly (i.e., due to unknown adulterants) Co-use of non-opioid drugs (particularly psychostimulants [e.g., methamphetamine], cocaine, and benzodiazepines) AND opioids, knowingly or unknowingly Co-use of other combinations of drugs that may result in drug overdose Applicants should focus on identifying risk and protective factors, AND patterns, AND trajectories of polydrug use for either 1) the general population OR 2) one or more of the following subpopulations of interest: Persons who have experienced acute or chronic pain and used prescription opioids to manage their pain Persons who use cannabis, either medically or non-medically Applicants may also use prior research or preliminary data to justify an alternate subpopulation of interest, such as other groups which have been disproportionately affected by overdose. The overall goal of this research is to better understand risk and protective factors for and patterns and trajectories of polydrug use in order to inform targeted drug use and overdose prevention efforts.
Who has won Injury Prevention and Control Research and State and Community Based Programs grants before
From fiscal 2021 to 2025, Injury Prevention and Control Research and State and Community Based Programs (93.136) awarded $2.2 billion across 986 grant awards, an average of $2.2 million per award.
| Recipient | State | Awards | Amount |
|---|---|---|---|
| Florida Department of Health | Florida | 12 | $81.1 million |
| California Department of Public Health | California | 11 | $55.4 million |
| Ohio Department of Health | Ohio | 9 | $42.0 million |
| North Carolina Department of Health & Human Services | North Carolina | 12 | $42.0 million |
| Michigan Department of Health and Human Services | Michigan | 10 | $37.9 million |
Applying now
This notice no longer takes applications. Apply under the newer notice, PA-27-100, which is open now.
The notice on Grants.gov keeps its full text and attachments, which is useful for planning a resubmission.
Questions people ask
Is RFA-CE-22-011 still open?
No. It closed on February 24, 2022. A newer notice is open: PA-27-100, due dates in the notice, expires April 5, 2027.
Who can apply for Understanding Polydrug Use Risk and Protective Factors, Patterns, and Trajectories to Prevent Drug Overdose?
Centers for Disease Control and Prevention - ERA accepted applications from any type of organization. The notice adds further conditions, so read its eligibility section.
What is the deadline for Understanding Polydrug Use Risk and Protective Factors, Patterns, and Trajectories to Prevent Drug Overdose?
Closed February 24, 2022. Applications are no longer accepted; the program's newer notices are on this page when there are any.
How much funding is available?
Awards of up to $350,000 each. About $5.3 million in total across about 5 awards.
Who has won Injury Prevention and Control Research and State and Community Based Programs grants before?
The largest recipients over five fiscal years were Florida Department of Health, California Department of Public Health, Ohio Department of Health. The program made 986 awards worth $2.2 billion in that time.
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