RFA-AI-21-041: Innate Immune Memory Impacting HIV Acquisition and/or Control (R21 Clinical Trial Not Allowed)
Closed
This grant is closed. Who won this program's grants before is below, and similar open grants are at the end of the page. It is in our archive of National Institutes of Health notices from 2021.
National Institutes of Health offered grants to nonprofits, colleges and universities, state and local governments, tribes, small businesses and businesses. Applications closed on December 6, 2021.
From the official notice on Grants.gov, last changed July 7, 2021. Checked November 7, 2026.
- Award amountsNot given on Grants.gov
- Cost sharingNot required
- Funding typeGrant
About this NIH notice
- Activity codeR21
- Clinical trialsNot allowed
- Funded byNIAID
- Median yearly award$235,125
- Typical project length3 years
- R21, Exploratory/Developmental Research Grant. Early, exploratory ideas that may not have preliminary data yet, usually for up to two years. Other open R21 notices.
Projects funded under RFA-AI-21-041 were run by National Institute of Allergy and Infectious Diseases (NIAID, 8 projects). Contact the program officer at the institute that fits your project before you apply; the notice lists them.
Application due dates, page limits and budget limits are set in the notice. Read RFA-AI-21-041 in the NIH Guide.
Key dates
| Posted | July 7, 2021 |
|---|---|
| Deadline | December 6, 2021 |
| Archived by Grants.gov | January 11, 2022 |
Who can apply
This opportunity was open to nonprofits, colleges and universities, state and local governments, tribes, small businesses and businesses.
All 15 applicant types the notice lists
- State governments
- County governments
- City or township governments
- Special district governments
- Independent school districts
- Public and State controlled institutions of higher education
- Native American tribal governments (Federally recognized)
- Public housing authorities/Indian housing authorities
- Native American tribal organizations (other than Federally recognized tribal governments)
- Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education
- Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education
- Private institutions of higher education
- For profit organizations other than small businesses
- Small businesses
- Others (see text field entitled "Additional Information on Eligibility" for clarification)
Other Eligible Applicants include the following: Alaska Native and Native Hawaiian Serving Institutions; Asian American Native American Pacific Islander Serving Institutions (AANAPISISs); Eligible Agencies of the Federal Government; Faith-based or Community-based Organizations; Hispanic-serving Institutions; Historically Black Colleges and Universities (HBCUs); Indian/Native American Tribal Governments (Other than Federally Recognized); Non-domestic (non-U.S.) Entities (Foreign Organizations); Regional Organizations; Tribally Controlled Colleges and Universities (TCCUs) ; U.S. Territory or Possession; Non-domestic (non-U.S.) Entities (Foreign Institutions) are eligible to apply. Non-domestic (non-U.S.) components of U.S. Organizations are eligible to apply. Foreign components, as defined in the NIH Grants Policy Statement, are allowed.
Is this a realistic fit?
- Most of the money in the 2 programs behind this notice (68% over five years) went to colleges and universities.
- No cost sharing or match is required.
What the grant funds
The purpose of this Funding Opportunity Announcement is to investigate innate immune cell effector functions and innate immune memory as a means to prevent HIV infection and/or establishment of disease. Exploratory research from basic molecular mechanisms, translational work, and clinical research examining innate memory are encouraged.
Funded under RFA-AI-21-041 so far
NIH funded 8 projects under RFA-AI-21-041 in fiscal 2022 to 2024, at 7 institutions. The median yearly award was $235,125.
| Project | Institution | Fiscal year | Award |
|---|---|---|---|
| Epigenetic Histone Landscape Profiles in HIV | Stanford University | 2024 | $133,135 |
| Trained immunity induced by Nef-containing extracellular vesicles | George Washington University | 2023 | $201,875 |
| Mechanisms of Trained Immunity in HIV Immune Responses | University of California Los Angeles | 2023 | $195,000 |
| Pathways modulating memory-like properties in NK cells and their impact on HIV control | George Washington University | 2023 | $242,250 |
| Identification of protective innate immune memory responses against HIV acquisition in the human female genital tract | Tufts University Boston | 2023 | $13,750 |
| Characterizing ART-free NK cell-mediated control of HIV infection in people living with HIV | J. David Gladstone Institutes | 2023 | $236,250 |
| Role of eosinophils in SIV infection | Duke University | 2023 | $201,250 |
| NK cell memory subsets and their impact on HIV disease progression and vaccination | Henry M. Jackson FDN for the Adv Mil/Med | 2023 | $263,402 |
Who has won Allergy and Infectious Diseases Research grants before
From fiscal 2021 to 2025, Allergy and Infectious Diseases Research (93.855) awarded $22 billion across 13,282 grant awards, an average of $1.6 million per award.
| Recipient | State | Awards | Amount |
|---|---|---|---|
| Fred Hutchinson Cancer Center | Washington | 85 | $938 million |
| Duke University | North Carolina | 230 | $781 million |
| University of California, Los Angeles | California | 138 | $745 million |
| The Johns Hopkins University | Maryland | 321 | $668 million |
| Emory University | Georgia | 282 | $650 million |
Who has won Drug Use and Addiction Research Programs grants before
From fiscal 2021 to 2025, Drug Use and Addiction Research Programs (93.279) awarded $7.3 billion across 5,071 grant awards, an average of $1.4 million per award.
| Recipient | State | Awards | Amount |
|---|---|---|---|
| Yale Univ | Connecticut | 150 | $305 million |
| The Johns Hopkins University | Maryland | 156 | $262 million |
| University of California, San Diego | California | 120 | $242 million |
| University of Pittsburgh - of the Commonwealth System of Higher Education | Pennsylvania | 100 | $182 million |
| New York University | New York | 62 | $173 million |
Applying now
This notice no longer takes applications. Agencies often post the same opportunity again under a new number, so check the program's notices on Grants.gov and the similar open grants below.
The notice on Grants.gov keeps its full text and attachments, which is useful for planning a resubmission.
Questions people ask
Is RFA-AI-21-041 still open?
No. It closed on December 6, 2021.
Who can apply for Innate Immune Memory Impacting HIV Acquisition and/or Control (R21 Clinical Trial Not Allowed)?
National Institutes of Health accepted applications from nonprofits, colleges and universities, state and local governments, tribes, small businesses and businesses. The notice adds further conditions, so read its eligibility section.
What is the deadline for Innate Immune Memory Impacting HIV Acquisition and/or Control (R21 Clinical Trial Not Allowed)?
Closed December 6, 2021. Applications are no longer accepted; the program's newer notices are on this page when there are any.
Who has been funded under RFA-AI-21-041?
NIH RePORTER lists 8 projects funded under RFA-AI-21-041 in fiscal 2022 to 2024, at 7 institutions. The most were at George Washington University, Stanford University, University of California Los Angeles.
Who has won Drug Use and Addiction Research Programs grants before?
The largest recipients over five fiscal years were Yale Univ, The Johns Hopkins University, University of California, San Diego. The program made 5,071 awards worth $7.3 billion in that time.
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