Well Told Grants

Grants / Department of Health and Human Services / National Institutes of Health

RFA-AI-21-019: Radiation-Induced Immune Dysfunction (U01 Clinical Trial Not Allowed)

Closed Closed August 24, 2021 Opportunity RFA-AI-21-019

This grant is closed. Who won this program's grants before is below, and similar open grants are at the end of the page. It is in our archive of National Institutes of Health notices from 2021.

National Institutes of Health offered grants to nonprofits, colleges and universities, state and local governments, tribes, small businesses and businesses. Applications closed on August 24, 2021.

From the official notice on Grants.gov, last changed April 2, 2021. Checked November 7, 2026.

About this NIH notice

Projects funded under RFA-AI-21-019 were run by National Institute of Allergy and Infectious Diseases (NIAID, 8 projects). Contact the program officer at the institute that fits your project before you apply; the notice lists them.

Application due dates, page limits and budget limits are set in the notice. Read RFA-AI-21-019 in the NIH Guide.

Key dates

PostedApril 2, 2021
DeadlineAugust 24, 2021
Archived by Grants.govSeptember 29, 2021

Who can apply

This opportunity was open to nonprofits, colleges and universities, state and local governments, tribes, small businesses and businesses.

All 15 applicant types the notice lists

Other Eligible Applicants include the following: Alaska Native and Native Hawaiian Serving Institutions; Asian American Native American Pacific Islander Serving Institutions (AANAPISISs); Eligible Agencies of the Federal Government; Faith-based or Community-based Organizations; Hispanic-serving Institutions; Historically Black Colleges and Universities (HBCUs); Indian/Native American Tribal Governments (Other than Federally Recognized); Non-domestic (non-U.S.) Entities (Foreign Organizations); Regional Organizations; Tribally Controlled Colleges and Universities (TCCUs) ; U.S. Territory or Possession; Non-domestic (non-U.S.) Entities (Foreign Institutions) are not eligible to apply. Non-domestic (non-U.S.) components of U.S. Organizations are not eligible to apply. Foreign components, as defined in the NIH Grants Policy Statement, are allowed.

More grants for nonprofits, colleges and universities, state and local governments, tribes, small businesses, businesses.

Is this a realistic fit?

What the grant funds

Research funded by this initiative will examine the effects of radiation exposure on the immune system and explore possible treatments for radiation-induced immune dysfunction. Research gaps exist in understanding the mechanisms of injury and repair with regard to radiation-induced immune system dysfunction, and these gaps must be addressed to better develop MCMs for radiation exposure. Through this initiative, the NIAID Radiation and Nuclear Countermeasures Program (RNCP) will support development of animal models for immune-targeted radiation injuries, studies to better understand radiation impacts on the immune system (including immune system-mediated multi-organ injury), identification of immune-specific pathways targeted by radiation, as well as biomarkers of exposure and mitigators/treatments that target immune-related radiation response pathways.

Category: Health.

Funded under RFA-AI-21-019 so far

NIH funded 8 projects under RFA-AI-21-019 in fiscal 2022 to 2026, at 8 institutions. The median yearly award was $582,293.

Recently funded projects
ProjectInstitutionFiscal yearAward
Radiation-Induced Paneth Cell Dysfunction U01University of Tennessee Health Sci Ctr2026$510,592
Mitigation of Radiation Induced Immune Dysfunction by PrC-210 Treatment U01Henry M. Jackson FDN for the Adv Mil/Med2026$349,970
Mechanisms of Radiation-Induced Innate Immune Dysfunction and Its Countermeasures U01Feinstein Institute for Medical Research2026$418,748
Modulation of signaling from damage-associated molecular patterns to improve radiation-induced thymic dysfunction U01Fred Hutchinson Cancer Center2026$606,406
Metabolic impairment plays a critical role in radiation-induced T cell immune dysfunction U01Georgetown University2026$564,759
Regeneration of the Immune System after Radiation Exposure U01Albert Einstein College of Medicine2026$582,293
Modulation of chemokine signaling to mitigate radiation induced inflammation U01University of Kansas Medical Center2026$676,560
Platelets in radiation-induced immune dysregulation U01Univ of Arkansas for Med Scis2026$636,257

From NIH RePORTER, which lists each project once per fiscal year it was funded. Amounts are the yearly award.

Who has won Allergy and Infectious Diseases Research grants before

From fiscal 2021 to 2025, Allergy and Infectious Diseases Research (93.855) awarded $22 billion across 13,282 grant awards, an average of $1.6 million per award.

Largest recipients, fiscal 2021 to 2025
RecipientStateAwardsAmount
Fred Hutchinson Cancer CenterWashington85$938 million
Duke UniversityNorth Carolina230$781 million
University of California, Los AngelesCalifornia138$745 million
The Johns Hopkins UniversityMaryland321$668 million
Emory UniversityGeorgia282$650 million

Top states: California ($3.4 billion), Massachusetts ($2.1 billion), Washington ($1.9 billion), New York ($1.8 billion), North Carolina ($1.5 billion).

Applying now

This notice no longer takes applications. Agencies often post the same opportunity again under a new number, so check the program's notices on Grants.gov and the similar open grants below.

The notice on Grants.gov keeps its full text and attachments, which is useful for planning a resubmission.

Questions people ask

Is RFA-AI-21-019 still open?

No. It closed on August 24, 2021.

Who can apply for Radiation-Induced Immune Dysfunction (U01 Clinical Trial Not Allowed)?

National Institutes of Health accepted applications from nonprofits, colleges and universities, state and local governments, tribes, small businesses and businesses. The notice adds further conditions, so read its eligibility section.

What is the deadline for Radiation-Induced Immune Dysfunction (U01 Clinical Trial Not Allowed)?

Closed August 24, 2021. Applications are no longer accepted; the program's newer notices are on this page when there are any.

Who has been funded under RFA-AI-21-019?

NIH RePORTER lists 8 projects funded under RFA-AI-21-019 in fiscal 2022 to 2026, at 8 institutions. The most were at University of Tennessee Health Sci Ctr, Henry M. Jackson FDN for the Adv Mil/Med, Feinstein Institute for Medical Research.

Who has won Allergy and Infectious Diseases Research grants before?

The largest recipients over five fiscal years were Fred Hutchinson Cancer Center, Duke University, University of California, Los Angeles. The program made 13,282 awards worth $22 billion in that time.

Similar open grants