RFA-AG-22-011: Early-Phase Clinical Trials of Novel Interventions to Prevent, Delay, or Treat Aging-Related Conditions by Targeting Aging-Related Mechanisms (U01 Clinical Trial Required)
Closed
This grant is closed. Who won this program's grants before is below, and similar open grants are at the end of the page. It is in our archive of National Institutes of Health notices from 2021.
National Institutes of Health offered grants to nonprofits, colleges and universities, state and local governments, tribes, small businesses and businesses. It expected to make $4.5 million in total. Applications closed on June 17, 2021.
From the official notice on Grants.gov, last changed February 3, 2021. Checked November 7, 2026.
- Total funding$4.5 million
- Cost sharingNot required
- Funding typeCooperative Agreement
About this NIH notice
- Activity codeU01
- Clinical trialsRequired
- Funded byNIA
- Median yearly award$819,181
- Typical project length5 years
- U01, Research Project Cooperative Agreement. Like an R01, but NIH staff are substantially involved in the work. Other open U01 notices.
Projects funded under RFA-AG-22-011 were run by National Institute on Aging (NIA, 4 projects). Contact the program officer at the institute that fits your project before you apply; the notice lists them.
Application due dates, page limits and budget limits are set in the notice. Read RFA-AG-22-011 in the NIH Guide.
Key dates
| Posted | February 3, 2021 |
|---|---|
| Deadline | June 17, 2021 |
| Archived by Grants.gov | July 23, 2021 |
Who can apply
This opportunity was open to nonprofits, colleges and universities, state and local governments, tribes, small businesses and businesses.
All 15 applicant types the notice lists
- State governments
- County governments
- City or township governments
- Special district governments
- Independent school districts
- Public and State controlled institutions of higher education
- Native American tribal governments (Federally recognized)
- Public housing authorities/Indian housing authorities
- Native American tribal organizations (other than Federally recognized tribal governments)
- Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education
- Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education
- Private institutions of higher education
- For profit organizations other than small businesses
- Small businesses
- Others (see text field entitled "Additional Information on Eligibility" for clarification)
Other Eligible Applicants include the following: Alaska Native and Native Hawaiian Serving Institutions; Asian American Native American Pacific Islander Serving Institutions (AANAPISISs); Eligible Agencies of the Federal Government; Faith-based or Community-based Organizations; Hispanic-serving Institutions; Historically Black Colleges and Universities (HBCUs); Indian/Native American Tribal Governments (Other than Federally Recognized); Regional Organizations; Tribally Controlled Colleges and Universities (TCCUs) ; U.S. Territory or Possession; Non-domestic (non-U.S.) Entities (Foreign Institutions) are not eligible to apply. Non-domestic (non-U.S.) components of U.S. Organizations are eligible to apply. Foreign components, as defined in the NIH Grants Policy Statement, are allowed.
Is this a realistic fit?
- Most of the program's money (73% over five years) went to colleges and universities.
- No cost sharing or match is required.
What the grant funds
NIA invites applications for Phase 1, 2a, and 2b clinical trials of new compounds or re-purposed existing drugs, biologics (except stem cells), or supplements to treat multiple chronic conditions by modulating fundamental aging-related mechanisms as well as to test compounds that could affect the individual diseases and conditions disproportionally affecting older adults. This FOA is not intended to provide support for definitive efficacy and safety trials.
Funded under RFA-AG-22-011 so far
NIH funded 4 projects under RFA-AG-22-011 in fiscal 2022 to 2024, at 4 institutions. The median yearly award was $819,181.
| Project | Institution | Fiscal year | Award |
|---|---|---|---|
| Repurposing of Metormin for Older Patients with HFpEF | Wake Forest University Health Sciences | 2024 | $738,245 |
| NAD Augmentation to Treat Diabetic Kidney Disease: A Randomized Controlled Trial | Brigham and Women's Hospital | 2024 | $857,882 |
| Clinical evaluation of mTORC1 inhibition for geroprotection. | University of Wisconsin-Madison | 2024 | $1.5 million |
| Senolytics To slOw Progression of Sepsis (STOP-Sepsis) trial | University of Minnesota | 2024 | $479,194 |
Who has won Aging Research grants before
From fiscal 2021 to 2025, Aging Research (93.866) awarded $19 billion across 11,026 grant awards, an average of $1.7 million per award.
| Recipient | State | Awards | Amount |
|---|---|---|---|
| The Regents of the University of California, San Francisco | California | 337 | $575 million |
| The Trustees of Columbia University in the City of New York | New York | 242 | $574 million |
| University of Southern California | California | 203 | $572 million |
| The Washington University | Missouri | 210 | $556 million |
| Regents of the University of Michigan | Michigan | 232 | $538 million |
Applying now
This notice no longer takes applications. Agencies often post the same opportunity again under a new number, so check the program's notices on Grants.gov and the similar open grants below.
The notice on Grants.gov keeps its full text and attachments, which is useful for planning a resubmission.
Questions people ask
Is RFA-AG-22-011 still open?
No. It closed on June 17, 2021.
Who can apply for Early-Phase Clinical Trials of Novel Interventions to Prevent, Delay, or Treat Aging-Related Conditions by Targeting Aging-Related Mechanisms (U01 Clinical Trial Required)?
National Institutes of Health accepted applications from nonprofits, colleges and universities, state and local governments, tribes, small businesses and businesses. The notice adds further conditions, so read its eligibility section.
What is the deadline for Early-Phase Clinical Trials of Novel Interventions to Prevent, Delay, or Treat Aging-Related Conditions by Targeting Aging-Related Mechanisms (U01 Clinical Trial Required)?
Closed June 17, 2021. Applications are no longer accepted; the program's newer notices are on this page when there are any.
How much funding is available?
About $4.5 million in total.
Who has been funded under RFA-AG-22-011?
NIH RePORTER lists 4 projects funded under RFA-AG-22-011 in fiscal 2022 to 2024, at 4 institutions. The most were at Wake Forest University Health Sciences, Brigham and Women's Hospital, University of Wisconsin-Madison.
Who has won Aging Research grants before?
The largest recipients over five fiscal years were The Regents of the University of California, San Francisco, The Trustees of Columbia University in the City of New York, University of Southern California. The program made 11,026 awards worth $19 billion in that time.
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