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NSF PD-23-5345: Engineering of Biomedical Systems

Closed Closed Opportunity NSF PD-23-5345

This grant is closed. A newer notice from the same program is open now: Major Research Instrumentation Program: (MRI) (NSF 27-500). Status: Closes January 29, 2027 (83 days left). It is in our archive of U.S. National Science Foundation notices from 2023.

U.S. National Science Foundation offered grants to any type of organization. It expected to make $10.4 million in total. It is no longer open on Grants.gov.

From the official notice on Grants.gov, last changed August 12, 2026. Checked November 7, 2026.

Other notices with this title

U.S. National Science Foundation has posted this title under other numbers: earlier or later rounds, or the same competition for another area. Each has its own dates and may change its rules.

NoticePostedDeadlineStatus
NSF PD-18-5345June 6, 2025ClosedClosed
NSF PD-20-5345June 6, 2025ClosedClosed
NSF PD-17-5345June 6, 2025ClosedClosed

Key dates

PostedJune 18, 2023
Archived by Grants.govAugust 13, 2026

Who can apply

This opportunity was open to any type of organization.

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Is this a realistic fit?

What the grant funds

The Engineering of Biomedical Systems program is part of the Engineering Biology and Health cluster, which also includes: 1) the Biophotonics program; 2) the Biosensing program; 3) the Cellular and Biochemical Engineering program; and 4) the Disability and Rehabilitation Engineering program. The goal of the Engineering of Biomedical Systems (EBMS) program is to provide opportunities for fundamental and transformative research projects that integrate engineering and life sciences to solve biomedical problems and serve humanity in the long term. Projects are expected to use an engineering framework (for example, design or modeling) that supports increased understanding of physiological or pathophysiological processes. Projects must include objectives that advance both engineering and biomedical sciences. Projects may include: methods, models, and enabling tools applied to understand or control living systems; fundamental improvements in deriving information from cells, tissues, organs, and organ systems; or new approaches to the design of systems that include both living and non-living components for eventual medical use in the long term. The EBMS program supports fundamental and transformative research in the following areas of biomedical engineering: Development of validated models (living or computational) of healthy and pathological tissues and organ systems that can support improved fundamental understanding of these systems or that could be applied in the future for development and testing of medical interventions; Design and validation of systems that integrate living and non-living components for improved understanding of physiology that could be applied in the future for diagnosis, monitoring, and treatment of disease or injury; Design and subsequent application of technologies and tools to investigate fundamental physiological and pathophysiological processes; Advanced biomanufacturing of three-dimensional tissues and organs; and Application of engineering tools and principles, including mathematical modeling, to quantitatively study the immune system in health and disease and to develop techniques for controlling and modulating a host’s immune response to challenges such as infectious diseases, cancer, implants, autoimmune disorders, wounds, etc. The long-term impact of the projects can be related to effective disease diagnosis and/or treatment, or improved health care delivery.

Category: Science and Technology and other Research and Development.

Who has won Engineering grants before

From fiscal 2021 to 2025, Engineering (47.041) awarded $4.3 billion across 11,244 grant awards, an average of $385,774 per award.

Largest recipients, fiscal 2021 to 2025
RecipientStateAwardsAmount
Georgia Tech Research CorpGeorgia193$106 million
Purdue UniversityIndiana238$106 million
Regents of the University of MichiganMichigan250$101 million
University of California, San DiegoCalifornia114$96.4 million
The Trustees of the University of PennsylvaniaPennsylvania59$80.6 million

Top states: California ($485 million), Texas ($346 million), New York ($297 million), Pennsylvania ($269 million), Massachusetts ($265 million).

Applying now

This notice no longer takes applications. Apply under the newer notice, NSF 27-500, which is open now.

The notice on Grants.gov keeps its full text and attachments, which is useful for planning a resubmission.

Questions people ask

Is NSF PD-23-5345 still open?

No. It is no longer open on Grants.gov. A newer notice is open: NSF 27-500, closes January 29, 2027 (83 days left).

Who can apply for Engineering of Biomedical Systems?

U.S. National Science Foundation accepted applications from any type of organization.

What is the deadline for Engineering of Biomedical Systems?

Closed. Applications are no longer accepted; the program's newer notices are on this page when there are any.

How much funding is available?

About $10.4 million in total.

Who has won Engineering grants before?

The largest recipients over five fiscal years were Georgia Tech Research Corp, Purdue University, Regents of the University of Michigan. The program made 11,244 awards worth $4.3 billion in that time.

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