Grants / Department of Health and Human Services / National Institutes of Health

PAS-21-215: Identification of Positive Valence System Related Targets for Novel Suicide Prevention Approaches (R21 Clinical Trial Optional)

Closed Closed October 16, 2021 Opportunity PAS-21-215 ☆ Save

This grant is closed. Who won this program's grants before is below, and similar open grants are at the end of the page. It is in our archive of National Institutes of Health notices from 2021.

• Award amountsNot given on Grants.gov
• Cost sharingNot required
• Funding typeGrant

Key dates

Who can apply

This opportunity was open to nonprofits, colleges and universities, state and local governments, tribes, small businesses and businesses.

Other Eligible Applicants include the following: Alaska Native and Native Hawaiian Serving Institutions; Asian American Native American Pacific Islander Serving Institutions (AANAPISISs); Eligible Agencies of the Federal Government; Faith-based or Community-based Organizations; Hispanic-serving Institutions; Historically Black Colleges and Universities (HBCUs); Indian/Native American Tribal Governments (Other than Federally Recognized); Non-domestic (non-U.S.) Entities (Foreign Organizations); Regional Organizations; Tribally Controlled Colleges and Universities (TCCUs) ; U.S. Territory or Possession.

More grants for nonprofits, colleges and universities, state and local governments, tribes, small businesses, businesses.

Is this a realistic fit?

• Most of the program's money (69% over five years) went to colleges and universities.
• No cost sharing or match is required.

What the grant funds

The primary objective of this FOA is to solicit research projects with the aim of elucidating the role of positive affect and related processes in suicidal individuals and evaluating modifiable behavioral and neural targets. Specifically, studies should include clinical populations with high risk of suicide, suicide attempters or acutely suicidal individuals, and may also include non-suicidal patients, high risk individuals in an absence of diagnosis, or healthy control groups. Projects across developmental spectrum are encouraged. Research projects should aim to 1) specify a construct of interest either in terms of research domain criteria: positive valence system (RDoC PVS), or a symptom relevant construct, such as an anhedonia/ anhedonia subtype, cognitive process such as present/future reward decision making, generating reasons for living in the context of anticipation of positive experiences, etc. 2) demonstrate that measures of the construct are reliable and reproducible and engage brain subsystem relevant to positive affect, and/or 3) show active modification of targeted brain system and behavioral measures of the construct through behavioral training or other means such as use of non-invasive neuromodulation, pharmacological or psychosocial therapeutic probes. Behavioral tasks used may include both novel and established tasks within the RDoC positive valence domain (e.g. reward sensitivity, reward valuation, and reward learning) and/or tasks probing components and subconstructs of hedonic and related processes. Use of measures of the dynamic changes in PA is strongly encouraged to further establish co-occurrence with other risk factors and suicidality.

Category: Health.

Applying now

This notice no longer takes applications. Agencies often post the same opportunity again under a new number, so check the program's notices on Grants.gov and the similar open grants below.

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