PAR-23-199: ClinGen Genomic Curation Expert Panels (U24 Clinical Trial Not Allowed)
Closed
This grant is closed. Who won this program's grants before is below, and similar open grants are at the end of the page. It is in our archive of National Institutes of Health notices from 2023.
National Institutes of Health offered grants of up to $220,000 to nonprofits, colleges and universities, state and local governments, tribes, small businesses and businesses. Applications closed on May 25, 2025.
From the official notice on Grants.gov, last changed June 6, 2023. Checked November 7, 2026.
- Award ceiling$220,000
- Cost sharingNot required
- Funding typeCooperative Agreement
About this NIH notice
- Activity codeU24
- Clinical trialsNot allowed
- Funded byNICHD, NCI, NINDS
- Median yearly award$349,002
- Typical project length6 years
- U24, Resource-Related Research Project Cooperative Agreement. Shared research resources such as data centers or coordinating centers, with substantial NIH involvement. Other open U24 notices.
Projects funded under PAR-23-199 were run by Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD, 5 projects), National Cancer Institute (NCI, 4 projects), National Institute of Neurological Disorders and Stroke (NINDS, 3 projects) and National Eye Institute (NEI, 2 projects), and 2 more. Contact the program officer at the institute that fits your project before you apply; the notice lists them.
Application due dates, page limits and budget limits are set in the notice. Read PAR-23-199 in the NIH Guide.
Key dates
| Posted | June 6, 2023 |
|---|---|
| Deadline | May 25, 2025 |
| Archived by Grants.gov | June 30, 2025 |
Who can apply
This opportunity was open to nonprofits, colleges and universities, state and local governments, tribes, small businesses and businesses.
All 15 applicant types the notice lists
- State governments
- County governments
- City or township governments
- Special district governments
- Independent school districts
- Public and State controlled institutions of higher education
- Native American tribal governments (Federally recognized)
- Public housing authorities/Indian housing authorities
- Native American tribal organizations (other than Federally recognized tribal governments)
- Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education
- Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education
- Private institutions of higher education
- For profit organizations other than small businesses
- Small businesses
- Others (see text field entitled "Additional Information on Eligibility" for clarification)
Other Eligible Applicants include the following: Alaska Native and Native Hawaiian Serving Institutions; Asian American Native American Pacific Islander Serving Institutions (AANAPISISs); Eligible Agencies of the Federal Government; Faith-based or Community-based Organizations; Hispanic-serving Institutions; Historically Black Colleges and Universities (HBCUs); Indian/Native American Tribal Governments (Other than Federally Recognized); Non-domestic (non-U.S.) Entities (Foreign Organizations); Regional Organizations; Tribally Controlled Colleges and Universities (TCCUs) ; U.S. Territory or Possession; Non-domestic (non-U.S.) Entities (Foreign Institutions) are not eligible to apply. Non-domestic (non-U.S.) components of U.S. Organizations are not eligible to apply. Foreign components, as defined in the NIH Grants Policy Statement, are allowed.
Is this a realistic fit?
- Projects NIH funded under this notice had a median yearly award of $349,002; it allows up to $220,000 per award.
- Most of the money in the 7 programs behind this notice (75% over five years) went to colleges and universities.
- No cost sharing or match is required.
What the grant funds
NIH established a clinical genomics infrastructure to develop an openly accessible knowledgebase that promotes data sharing and provides standardized infrastructure and tools for determining the clinical relevance of genetic variants through two initiatives: the Clinical Genomics Resource (ClinGen) and the Clinical Variant Database (ClinVar) of clinical variation. ClinGen defines the clinical relevance of genes and variants for use in precision medicine and research by standardizing clinical annotation and interpretation of variants and implementing evidence-based expert consensus assertions. The purpose of this Notice of Funding Opportunity (NOFO) is to establish Expert Panels that will select genes and genomic variants associated with diseases or conditions of high priority to participating NIH Institutes and Centers (ICs) and systematically determine their clinical significance for diagnosis and treatment of these diseases or conditions. The Genomic Curation Expert Panels funded through this NOFO are required to utilize the NHGRI Clinical Genomics Resource (ClinGen) and the NCBI ClinVar procedures, interfaces, tools, and informatics infrastructure.
Funded under PAR-23-199 so far
NIH funded 16 projects under PAR-23-199 in fiscal 2024 to 2026, at 12 institutions. The median yearly award was $349,002.
| Project | Institution | Fiscal year | Award |
|---|---|---|---|
| Expanding the ClinGen Lysosomal Storage Disorder Curation Effort: VCEPs for Mucopolysaccharidosis Type II and IIIA | Mayo Clinic Rochester | 2026 | $352,880 |
| Gene and Variant Curation Expert Panels for Hearing Loss | Indiana University Indianapolis | 2026 | $341,942 |
| Curation of Muscular Dystrophy Genes | Washington University | 2026 | $290,043 |
| ClinGen Expert Curation Panel for the Epilepsies | Children's Hosp of Philadelphia | 2026 | $379,484 |
| Neurofibromatosis and Schwannomatosis Genes Variant Curation Expert Panel (VCEP) | Massachusetts General Hospital | 2026 | $286,701 |
| Brain Malformation Expert Panels for Gene and Variant Curation | Boston Children's Hospital | 2026 | $377,718 |
| Expert curation of clinically significant variants in genes for early onset retinal degeneration | University of California, San Diego | 2026 | $346,004 |
| Integrative Curation of Clinically Relevant Variants in X-Linked Inherited Retinal Disease Genes | Baylor College of Medicine | 2026 | $352,000 |
Who has won Extramural Research Programs in the Neurosciences and Neurological Disorders grants before
From fiscal 2021 to 2025, Extramural Research Programs in the Neurosciences and Neurological Disorders (93.853) awarded $9.1 billion across 8,641 grant awards, an average of $1.0 million per award.
| Recipient | State | Awards | Amount |
|---|---|---|---|
| The General Hospital Corporation | Massachusetts | 203 | $288 million |
| The Regents of the University of California, San Francisco | California | 248 | $277 million |
| The Johns Hopkins University | Maryland | 230 | $276 million |
| The Trustees of Columbia University in the City of New York | New York | 188 | $226 million |
| Regents of the University of Michigan | Michigan | 179 | $221 million |
Who has won Child Health and Human Development Extramural Research grants before
From fiscal 2021 to 2025, Child Health and Human Development Extramural Research (93.865) awarded $6.0 billion across 6,026 grant awards, an average of $1.0 million per award.
| Recipient | State | Awards | Amount |
|---|---|---|---|
| Regents of the University of Michigan | Michigan | 167 | $178 million |
| The Johns Hopkins University | Maryland | 133 | $146 million |
| University of Washington | Washington | 114 | $131 million |
| Baylor College of Medicine | Texas | 116 | $124 million |
| The Leland Stanford Junior University | California | 104 | $116 million |
Who has won Vision Research grants before
From fiscal 2021 to 2025, Vision Research (93.867) awarded $3.4 billion across 3,275 grant awards, an average of $1.0 million per award.
| Recipient | State | Awards | Amount |
|---|---|---|---|
| The Johns Hopkins University | Maryland | 137 | $139 million |
| The Leland Stanford Junior University | California | 87 | $96.5 million |
| The Regents of the University of California, San Francisco | California | 78 | $89.9 million |
| Duke University | North Carolina | 79 | $75.5 million |
| The Trustees of the University of Pennsylvania | Pennsylvania | 57 | $73.9 million |
Other programs behind this notice
- National Center for Advancing Translational Sciences
- Arthritis, Musculoskeletal and Skin Diseases Research
- Research Related to Deafness and Communication Disorders
- Cancer Control
Applying now
This notice no longer takes applications. Agencies often post the same opportunity again under a new number, so check the program's notices on Grants.gov and the similar open grants below.
The notice on Grants.gov keeps its full text and attachments, which is useful for planning a resubmission.
Questions people ask
Is PAR-23-199 still open?
No. It closed on May 25, 2025.
Who can apply for ClinGen Genomic Curation Expert Panels (U24 Clinical Trial Not Allowed)?
National Institutes of Health accepted applications from nonprofits, colleges and universities, state and local governments, tribes, small businesses and businesses. The notice adds further conditions, so read its eligibility section.
What is the deadline for ClinGen Genomic Curation Expert Panels (U24 Clinical Trial Not Allowed)?
Closed May 25, 2025. Applications are no longer accepted; the program's newer notices are on this page when there are any.
How much funding is available?
Awards of up to $220,000 each.
Who has been funded under PAR-23-199?
NIH RePORTER lists 16 projects funded under PAR-23-199 in fiscal 2024 to 2026, at 12 institutions. The most were at Baylor College of Medicine, Mayo Clinic Rochester, Boston Children's Hospital.
Who has won Research Related to Deafness and Communication Disorders grants before?
The largest recipients over five fiscal years were The Johns Hopkins University, Massachusetts Eye and Ear Infirmary, The University of Iowa. The program made 2,231 awards worth $2.1 billion in that time.
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